Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55518371 . G A CCDS603.1:NM_174936.3:c.706Ggc>Agc_NP_777596.2:p.236G>S Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 GLY A:236 NA:NA DO NA DO DO DO NA NA NA
GLY B:236 A:236 0.0 0.0 -60.4 138.8 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 GLY A:236 A:236 0.0 0.0 -62.8 136.4 0.0 0.0 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 GLY A:236 A:236 0.0 0.0 -51.7 136.9 0.0 0.0 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 GLY A:236 A:236 0.0 0.0 -63.4 141.5 0.0 0.0 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLY A:206 NA:NA DO NA DO DO DO NA NA NA
GLY B:206 B:236 0.0 0.0 -52.2 132.2 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLY A:206 NA:NA DO NA DO DO DO NA NA NA
GLY B:206 B:236 0.0 0.0 -48.0 137.0 0.0 0.0 0.0 HOH
 4.400
 CA
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLY A:206 NA:NA DO NA DO DO DO NA NA NA
GLY B:206 B:236 0.0 0.0 -50.9 135.3 0.0 0.0 0.0 HOH
 4.296
 CA
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLY A:206 NA:NA DO NA DO DO DO NA NA NA
GLY B:206 B:236 0.0 0.0 -59.9 133.7 0.0 0.0 0.0
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLY A:206 NA:NA DO NA DO DO DO NA NA NA
GLY B:206 B:236 0.0 0.0 -68.9 132.8 0.0 0.0 0.0 HOH
 8.993
 C
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLY A:206 NA:NA DO NA DO DO DO NA NA NA
GLY B:206 B:236 0.0 0.0 -44.4 131.5 0.0 0.0 0.0 HOH
 8.453
 O
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 GLY B:84 B:236 0.0 0.0 -56.7 141.6 0.0 0.0 0.0 HOH
 4.113
 CA
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 GLY B:84 A:236 0.0 0.0 -75.7 139.3 0.0 0.0 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 GLY B:84 A:236 0.0 0.0 -75.8 139.3 0.0 0.0 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 GLY B:84 A:236 0.0 0.0 -53.2 134.5 0.0 0.0 0.0 HOH
 4.016
 CA
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 GLY B:84 A:236 0.0 0.0 -50.5 133.1 0.0 0.0 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 GLY B:84 A:236 0.0 0.0 -49.5 136.8 0.0 0.0 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 GLY A:84 A:236 0.0 0.0 -60.6 139.2 0.0 0.0 0.0 HOH
 6.966
 O
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 GLY A:84 A:236 0.0 0.0 -56.8 135.2 0.0 0.0 0.0 HOH
 4.592
 C
 O
GLY B:84 B:236 0.0 0.0 -56.7 133.5 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 GLY B:84 B:236 0.0 0.0 -32.7 130.3 0.0 0.0 0.0 HOH
 4.959
 C
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 GLY B:84 B:236 0.0 0.0 -54.7 141.7 0.0 0.0 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 GLY B:84 B:236 0.0 0.0 -55.4 135.7 0.0 0.0 0.0 HOH
 4.380
 CA
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 GLY B:84 B:236 0.0 0.0 -56.1 150.2 0.0 0.0 0.0
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 GLY B:84 B:236 0.0 0.0 -63.9 149.3 0.0 0.0 0.0 HOH
 4.352
 CA
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 GLY B:84 B:236 0.0 0.0 -55.5 135.7 0.0 0.0 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 GLY B:84 B:236 0.0 0.0 -62.5 144.9 0.0 0.0 0.0 HOH
 4.226
 CA
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 GLY B:84 B:236 0.0 0.0 -58.9 148.2 0.0 0.0 0.0 NA
HOH
 5.612
4.107
 CA
CA
 NA
O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 GLY A:236 A:236 0.0 0.0 -62.1 140.1 0.0 0.0 0.0 HOH
 4.290
 CA
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 GLY A:236 A:236 0.0 0.0 -46.5 146.4 0.0 0.0 0.0
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 GLY A:236 A:236 0.0 0.0 -55.7 141.7 0.0 0.0 0.0 HOH
 4.404
 CA
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 GLY A:236 A:236 0.0 0.0 -52.9 144.9 0.0 0.0 0.0 HOH
 5.583
 CA
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 GLY B:84 B:236 0.0 0.0 -61.7 141.5 0.0 0.0 0.0 HOH
 4.437
 CA
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 GLY B:84 B:236 0.0 0.0 -54.9 139.3 0.0 0.0 0.0 HOH
 4.555
 CA
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 GLY B:84 B:236 0.0 0.0 -52.4 138.5 0.0 0.0 0.0 HOH
 4.538
 CA
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 GLY B:84 B:236 0.0 0.0 -53.5 140.7 0.0 0.0 0.0 HOH
 4.576
 CA
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 GLY B:84 B:236 0.0 0.0 -53.7 140.7 0.0 0.0 0.0 HOH
 4.569
 CA
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 GLY B:84 B:236 0.0 0.0 -57.4 143.6 0.0 0.0 0.0 HOH
 4.504
 CA
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 GLY B:84 B:236 0.0 0.0 -49.2 135.6 0.0 0.0 0.0 HOH
 4.302
 CA
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 GLY B:84 B:236 0.0 0.0 -57.2 144.7 0.0 0.0 0.0 HOH
 3.718
 C
 O
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 GLY A:84 A:236 0.0 0.0 -58.6 140.0 0.0 0.0 0.0 HOH
 4.139
 CA
 O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 GLY A:84 A:236 0.0 0.0 -56.5 139.8 0.0 0.0 0.0 HOH
 4.415
 CA
 O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 GLY A:84 A:236 0.0 0.0 -44.9 139.2 0.0 0.0 0.0 HOH
 9.330
 C
 O
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 GLY A:84 A:236 0.0 0.0 -54.1 136.3 0.0 0.0 0.0 HOH
 4.238
 CA
 O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 GLY A:84 A:236 0.0 0.0 -42.9 134.2 0.0 0.0 0.0
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 GLY A:84 A:236 0.0 0.0 -57.1 139.7 0.0 0.0 0.0 HOH
 3.834
 CA
 O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 GLY B:84 B:236 0.0 0.0 -57.6 130.2 0.0 0.0 0.0 EDO
 8.494
 O
 O1
GLY D:84 E:236 0.0 0.0 -58.5 131.6 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 GLY A:236 A:236 0.0 0.0 -44.6 145.6