Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55518374 . C A CCDS603.1:NM_174936.3:c.709Cgg>Agg_NP_777596.2:p.237R>R Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 ARG A:237 NA:NA DO NA DO DO DO NA NA NA
ARG B:237 A:237 148.0 0.658 T -48.4 -48.1 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ARG A:237 A:237 93.0 0.413 T -43.9 -48.5 93.0 0.413 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 ARG A:237 A:237 103.0 0.458 T -53.2 -50.6 103.0 0.458 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ARG A:237 A:237 93.0 0.413 T -52.5 -50.1 93.0 0.413 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:207 NA:NA DO NA DO DO DO NA NA NA
ARG B:207 B:237 111.0 0.493 T -50.4 -49.4 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:207 NA:NA DO NA DO DO DO NA NA NA
ARG B:207 B:237 105.0 0.467 T -51.6 -48.3 105.0 0.467 0.0 HOH
 4.782
 CB
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:207 NA:NA DO NA DO DO DO NA NA NA
ARG B:207 B:237 109.0 0.484 T -55.1 -42.6 109.0 0.484 0.0 HOH
 4.791
 CB
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:207 NA:NA DO NA DO DO DO NA NA NA
ARG B:207 B:237 78.0 0.347 T -59.4 -43.0 72.0 0.32 0.027 D:None:0.027
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:207 NA:NA DO NA DO DO DO NA NA NA
ARG B:207 B:237 80.0 0.356 T -60.7 -35.1 74.0 0.329 0.027 D:None:0.027
 HOH
 3.461
 NH1
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:207 NA:NA DO NA DO DO DO NA NA NA
ARG B:207 B:237 102.0 0.453 T -63.1 -41.6 102.0 0.453 0.0 HOH
 6.830
 O
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 ARG B:85 B:237 148.0 0.658 T -57.1 -43.8 148.0 0.658 0.0 HOH
 4.051
 CD
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ARG B:85 A:237 137.0 0.609 T -81.8 -31.4 137.0 0.609 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ARG B:85 A:237 134.0 0.596 T -81.7 -31.3 134.0 0.596 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 ARG B:85 A:237 118.0 0.524 T -45.4 -49.2 118.0 0.524 0.0 CA
HOH
 8.995
4.381
 NH2
NH2
 CA
O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ARG B:85 A:237 121.0 0.538 T -55.5 -41.1 121.0 0.538 0.0 CA
 9.309
 NH2
 CA
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ARG B:85 A:237 120.0 0.533 T -56.4 -43.9 120.0 0.533 0.0 CA
 8.814
 NH2
 CA
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 ARG A:85 A:237 131.0 0.582 T -62.1 -47.8 56.0 0.249 0.333 B:None:0.333
 HOH
 7.460
 O
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 ARG A:85 A:237 90.0 0.4 T -46.1 -49.8 90.0 0.4 0.0 HOH
 4.066
 NH2
 O
ARG B:85 B:237 138.0 0.613 T -48.8 -45.6 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 ARG B:85 B:237 103.0 0.458 T -61.3 -55.5 103.0 0.458 0.0 HOH
 2.714
 NE
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 ARG B:85 B:237 96.0 0.427 S -70.9 -32.1 68.0 0.302 0.125 D:Q7Z3Y4:0.124
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 ARG B:85 B:237 97.0 0.431 T -48.2 -48.8 97.0 0.431 0.0 HOH
 3.130
 NE
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 ARG B:85 B:237 93.0 0.413 T -67.5 -38.5 93.0 0.413 0.0
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 ARG B:85 B:237 100.0 0.444 T -71.9 -34.5 100.0 0.444 0.0 HOH
 5.681
 N
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 ARG B:85 B:237 97.0 0.431 T -48.1 -48.9 97.0 0.431 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 ARG B:85 B:237 86.0 0.382 T -71.5 -29.3 86.0 0.382 0.0 HOH
 2.729
 O
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 ARG B:85 B:237 114.0 0.507 T -62.2 -44.8 114.0 0.507 0.0 NA
HOH
 7.250
2.810
 N
NH1
 NA
O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ARG A:237 A:237 94.0 0.418 T -56.2 -40.2 94.0 0.418 0.0 HOH
 4.195
 CB
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ARG A:237 A:237 104.0 0.462 T -62.1 -40.4 104.0 0.462 0.0
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ARG A:237 A:237 93.0 0.413 T -60.7 -48.3 93.0 0.413 0.0 HOH
 4.439
 CB
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ARG A:237 A:237 102.0 0.453 T -58.8 -46.2 102.0 0.453 0.0 HOH
 7.227
 N
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 ARG B:85 B:237 100.0 0.444 T -55.9 -48.5 100.0 0.444 0.0 HOH
 2.752
 O
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ARG B:85 B:237 34.0 NA T -49.8 -46.8 34.0 NA NA HOH
 2.888
 O
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ARG B:85 B:237 107.0 0.476 T -46.5 -50.1 107.0 0.476 0.0 HOH
 2.789
 O
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ARG B:85 B:237 34.0 NA T -50.8 -48.8 34.0 NA NA HOH
 2.773
 O
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ARG B:85 B:237 109.0 0.484 T -53.1 -48.8 109.0 0.484 0.0 HOH
 2.793
 O
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ARG B:85 B:237 91.0 0.404 T -50.5 -49.7 91.0 0.404 0.0 HOH
 2.661
 O
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ARG B:85 B:237 96.0 0.427 T -43.2 -48.6 96.0 0.427 0.0 HOH
 4.027
 CB
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ARG B:85 B:237 183.0 0.813 T -61.1 -49.4 183.0 0.813 0.0 HOH
 2.865
 NH1
 O
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ARG A:85 A:237 127.0 0.564 T -66.3 -30.9 127.0 0.564 0.0 CA
HOH
 9.460
2.997
 NH1
NH2
 CA
O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ARG A:85 A:237 122.0 0.542 T -68.2 -32.6 122.0 0.542 0.0 CA
HOH
 9.692
2.878
 NH1
O
 CA
O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ARG A:85 A:237 136.0 0.604 T -67.7 -31.1 136.0 0.604 0.0 CA
HOH
 9.575
2.756
 NH2
NH2
 CA
O
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ARG A:85 A:237 124.0 0.551 T -64.6 -37.1 123.0 0.547 0.004 B:P01130:0.004
 CA
HOH
 9.833
2.807
 NH1
NH1
 CA
O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ARG A:85 A:237 136.0 0.604 T -66.3 -40.9 136.0 0.604 0.0 CA
 9.443
 NH2
 CA
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 ARG A:85 A:237 89.0 0.396 T -52.7 -43.3 38.0 0.169 0.227 D:None:0.227
 HOH
 2.694
 O
 O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 ARG B:85 B:237 130.0 0.578 T -51.1 -47.2 130.0 0.578 0.0 EDO
 7.617
 C
 C1
ARG D:85 E:237 123.0 0.547 T -47.2 -49.3 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 ARG A:237 A:237 98.0 0.436 S -69.5 -51.3