Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55518386 . G A CCDS603.1:NM_174936.3:c.721Gtg>Atg_NP_777596.2:p.241V>M Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 VAL A:241 NA:NA DO NA DO DO DO NA NA NA
VAL B:241 A:241 12.0 0.077 S -79.7 -46.4 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 VAL A:241 A:241 36.0 0.232 S -89.7 -60.4 2.0 0.013 0.219 B:None:0.219
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 VAL A:241 A:241 32.0 0.206 S -84.5 -57.2 2.0 0.013 0.193 D:None:0.194
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 VAL A:241 A:241 34.0 0.219 S -79.9 -51.3 2.0 0.013 0.206 B:None:0.206
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:211 NA:NA DO NA DO DO DO NA NA NA
VAL B:211 B:241 11.0 0.071 S -79.9 -47.0 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:211 NA:NA DO NA DO DO DO NA NA NA
VAL B:211 B:241 11.0 0.071 S -82.0 -51.7 11.0 0.071 0.0 HOH
 6.005
 CG2
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:211 NA:NA DO NA DO DO DO NA NA NA
VAL B:211 B:241 13.0 0.084 S -76.4 -51.4 13.0 0.084 0.0 HOH
 2.749
 O
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:211 NA:NA DO NA DO DO DO NA NA NA
VAL B:211 B:241 5.0 0.032 S -82.0 -60.9 5.0 0.032 0.0
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:211 NA:NA DO NA DO DO DO NA NA NA
VAL B:211 B:241 5.0 0.032 S -81.8 -61.1 5.0 0.032 0.0 HOH
 6.989
 O
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:211 NA:NA DO NA DO DO DO NA NA NA
VAL B:211 B:241 10.0 0.065 S -75.3 -56.1 10.0 0.065 0.0 HOH
 8.612
 O
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 VAL B:89 B:241 11.0 0.071 S -82.5 -51.2 11.0 0.071 0.0 HOH
 2.743
 O
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 VAL B:89 A:241 7.0 0.045 S -77.9 -61.0 7.0 0.045 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 VAL B:89 A:241 13.0 0.084 S -77.8 -61.1 13.0 0.084 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 VAL B:89 A:241 12.0 0.077 S -74.0 -59.0 12.0 0.077 0.0 HOH
 2.790
 O
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 VAL B:89 A:241 9.0 0.058 S -76.3 -63.4 9.0 0.058 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 VAL B:89 A:241 10.0 0.065 S -71.5 -61.0 10.0 0.065 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 VAL A:89 A:241 14.0 0.09 S -83.9 -55.0 14.0 0.09 0.0 HOH
 2.872
 O
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 VAL A:89 A:241 9.0 0.058 S -77.6 -48.9 9.0 0.058 0.0 HOH
 9.083
 N
 O
VAL B:89 B:241 10.0 0.065 S -76.6 -50.6 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 VAL B:89 B:241 10.0 0.065 S -75.5 -69.4 10.0 0.065 0.0 HOH
 3.594
 O
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 VAL B:89 B:241 30.0 0.194 S -74.8 -61.1 28.0 0.181 0.013 C:None:0.013
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 VAL B:89 B:241 9.0 0.058 S -84.3 -47.0 9.0 0.058 0.0 HOH
 2.731
 O
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 VAL B:89 B:241 8.0 0.052 S -72.6 -53.4 8.0 0.052 0.0 HOH
 9.695
 CG1
 O
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 VAL B:89 B:241 12.0 0.077 S -85.0 -47.2 12.0 0.077 0.0 HOH
 6.061
 N
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 VAL B:89 B:241 9.0 0.058 S -84.3 -47.0 9.0 0.058 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 VAL B:89 B:241 12.0 0.077 S -83.7 -51.1 12.0 0.077 0.0 HOH
 2.841
 O
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 VAL B:89 B:241 13.0 0.084 S -82.8 -51.3 13.0 0.084 0.0 NA
HOH
 6.020
2.788
 N
O
 NA
O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 VAL A:241 A:241 32.0 0.206 S -77.1 -57.1 1.0 0.006 0.2 B:None:0.2
 HOH
 2.731
 O
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 VAL A:241 A:241 32.0 0.206 S -77.4 -60.8 1.0 0.006 0.2 B:None:0.2
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 VAL A:241 A:241 30.0 0.194 S -82.6 -42.4 1.0 0.006 0.188 C:None:0.187
 HOH
 6.064
 N
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 VAL A:241 A:241 32.0 0.206 S -76.9 -55.8 2.0 0.013 0.193 B:None:0.194
 HOH
 6.000
 N
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 VAL B:89 B:241 13.0 0.084 S -84.2 -52.5 13.0 0.084 0.0 HOH
 2.836
 O
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 VAL B:89 B:241 8.0 0.052 S -79.9 -52.5 8.0 0.052 0.0 HOH
 2.825
 O
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 VAL B:89 B:241 0.0 0.0 S -79.6 -50.9 0.0 0.0 0.0 HOH
 2.863
 O
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 VAL B:89 B:241 7.0 0.045 S -80.6 -50.4 7.0 0.045 0.0 HOH
 2.824
 O
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 VAL B:89 B:241 12.0 0.077 S -82.7 -50.5 12.0 0.077 0.0 HOH
 2.881
 O
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 VAL B:89 B:241 12.0 0.077 S -82.4 -50.3 12.0 0.077 0.0 HOH
 2.808
 O
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 VAL B:89 B:241 9.0 0.058 S -73.8 -51.6 9.0 0.058 0.0 HOH
 2.853
 O
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 VAL B:89 B:241 35.0 0.226 S -78.9 -40.2 35.0 0.226 0.0 HOH
 2.719
 O
 O
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 VAL A:89 A:241 10.0 0.065 S -77.5 -60.0 10.0 0.065 0.0 HOH
 2.883
 O
 O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 VAL A:89 A:241 7.0 0.045 S -77.3 -52.6 7.0 0.045 0.0 HOH
 3.275
 O
 O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 VAL A:89 A:241 9.0 0.058 S -75.9 -52.7 9.0 0.058 0.0
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 VAL A:89 A:241 13.0 0.084 S -78.2 -49.7 13.0 0.084 0.0 HOH
 5.047
 O
 O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 VAL A:89 A:241 5.0 0.032 S -68.0 -72.2 5.0 0.032 0.0
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 VAL A:89 A:241 31.0 0.2 S -80.0 -47.1 31.0 0.2 0.0 HOH
 4.065
 CG2
 O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 VAL B:89 B:241 9.0 0.058 S -76.0 -55.2 9.0 0.058 0.0
VAL D:89 E:241 10.0 0.065 S -76.9 -54.7 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 VAL A:241 A:241 14.0 0.09 S -70.1 -62.7