Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55518402 . G A CCDS603.1:NM_174936.3:c.737aGc>aAc_NP_777596.2:p.246S>N Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 SER A:246 NA:NA DO NA DO DO DO NA NA NA
SER B:246 A:246 50.0 0.435 E -83.7 140.9 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 SER A:246 A:246 28.0 0.243 E -82.9 143.6 28.0 0.243 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 SER A:246 A:246 24.0 0.209 E -72.2 140.0 24.0 0.209 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 SER A:246 A:246 29.0 0.252 E -82.9 139.9 29.0 0.252 0.0 HOH
 9.957
 HG
 O
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 SER A:216 NA:NA DO NA DO DO DO NA NA NA
SER B:216 B:246 25.0 0.217 E -75.3 134.4 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 SER A:216 NA:NA DO NA DO DO DO NA NA NA
SER B:216 B:246 36.0 0.313 E -76.6 131.7 36.0 0.313 0.0 HOH
 3.938
 CB
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 SER A:216 NA:NA DO NA DO DO DO NA NA NA
SER B:216 B:246 42.0 0.365 E -78.7 133.5 42.0 0.365 0.0 EDO
HOH
 6.494
3.925
 OG
CB
 C2
O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 SER A:216 NA:NA DO NA DO DO DO NA NA NA
SER B:216 B:246 44.0 0.383 E -78.9 124.8 44.0 0.383 0.0
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 SER A:216 NA:NA DO NA DO DO DO NA NA NA
SER B:216 B:246 47.0 0.409 E -80.8 128.7 47.0 0.409 0.0
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 SER A:216 NA:NA DO NA DO DO DO NA NA NA
SER B:216 B:246 41.0 0.357 E -67.2 120.7 41.0 0.357 0.0 HOH
 3.727
 CB
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 SER B:94 B:246 58.0 0.504 E -81.7 138.9 58.0 0.504 0.0 HOH
 4.391
 OG
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 SER B:94 A:246 13.0 0.113 E -88.5 134.9 13.0 0.113 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 SER B:94 A:246 12.0 0.104 E -88.5 134.9 12.0 0.104 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 SER B:94 A:246 29.0 0.252 E -80.9 141.1 29.0 0.252 0.0 HOH
 3.567
 OG
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 SER B:94 A:246 30.0 0.261 E -72.2 138.6 30.0 0.261 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 SER B:94 A:246 29.0 0.252 E -69.5 135.5 29.0 0.252 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 SER A:94 A:246 38.0 0.33 E -112.8 126.4 38.0 0.33 0.0 HOH
 9.898
 N
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 SER A:94 A:246 28.0 0.243 E -87.6 130.0 28.0 0.243 0.0 HOH
 6.969
 N
 O
SER B:94 B:246 18.0 0.157 -71.5 134.6 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 SER B:94 B:246 29.0 0.252 E -72.2 126.6 29.0 0.252 0.0 HOH
 6.796
 N
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 SER B:94 B:246 33.0 0.287 E -90.1 132.4 33.0 0.287 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 SER B:94 B:246 46.0 0.4 E -83.7 137.5 46.0 0.4 0.0 HOH
 7.218
 CB
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 SER B:94 B:246 41.0 0.357 E -78.1 138.8 41.0 0.357 0.0 HOH
 2.458
 OG
 O
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 SER B:94 B:246 41.0 0.357 E -85.3 131.9 41.0 0.357 0.0 HOH
 2.568
 OG
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 SER B:94 B:246 45.0 0.391 E -83.6 137.6 45.0 0.391 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 SER B:94 B:246 30.0 0.261 E -84.8 135.1 30.0 0.261 0.0 HOH
 6.737
 N
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 SER B:94 B:246 32.0 0.278 -83.3 135.8 32.0 0.278 0.0 HOH
 2.538
 OG
 O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 SER A:246 A:246 40.0 0.348 E -97.4 144.6 40.0 0.348 0.0 HOH
 6.812
 OG
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 SER A:246 A:246 41.0 0.357 E -102.2 142.3 41.0 0.357 0.0
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 SER A:246 A:246 40.0 0.348 E -102.9 139.4 40.0 0.348 0.0 HOH
 4.164
 OG
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 SER A:246 A:246 44.0 0.383 E -97.6 150.5 44.0 0.383 0.0 HOH
 5.943
 OG
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 SER B:94 B:246 39.0 0.339 E -96.6 151.9 39.0 0.339 0.0 HOH
 2.777
 OG
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 SER B:94 B:246 52.0 0.452 E -87.7 147.2 52.0 0.452 0.0 HOH
 2.924
 OG
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 SER B:94 B:246 56.0 0.487 E -84.0 146.7 56.0 0.487 0.0 HOH
 2.993
 OG
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 SER B:94 B:246 57.0 0.496 E -88.5 145.9 57.0 0.496 0.0 HOH
 2.648
 OG
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 SER B:94 B:246 54.0 0.47 E -102.2 148.9 54.0 0.47 0.0 HOH
 2.686
 OG
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 SER B:94 B:246 56.0 0.487 E -100.1 149.2 56.0 0.487 0.0 HOH
 3.163
 OG
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 SER B:94 B:246 52.0 0.452 E -94.9 144.3 52.0 0.452 0.0 HOH
 9.242
 N
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 SER B:94 B:246 47.0 0.409 E -84.0 129.5 47.0 0.409 0.0 HOH
 2.537
 OG
 O
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 SER A:94 A:246 22.0 0.191 E -79.1 134.8 22.0 0.191 0.0 HOH
 3.783
 CB
 O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 SER A:94 A:246 30.0 0.261 E -78.7 137.9 30.0 0.261 0.0 HOH
 3.674
 CB
 O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 SER A:94 A:246 30.0 0.261 E -87.8 139.5 30.0 0.261 0.0
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 SER A:94 A:246 26.0 0.226 -78.6 137.3 26.0 0.226 0.0 HOH
 2.772
 OG
 O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 SER A:94 A:246 39.0 0.339 E -76.3 133.2 39.0 0.339 0.0
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 SER A:94 A:246 26.0 0.226 -86.5 127.4 26.0 0.226 0.0 HOH
 3.329
 N
 O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 SER B:94 B:246 39.0 0.339 E -100.1 144.7 39.0 0.339 0.0 HOH
 4.040
 CB
 O
SER D:94 E:246 40.0 0.348 E -140.5 139.3 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 SER A:246 A:246 29.0 0.252 E -90.7 140.4