Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr1 | 55518407 | . | C | A | CCDS603.1:NM_174936.3:c.742Cgc>Agc_NP_777596.2:p.248R>S | Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 2p4e | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2007-04-10 | ARG | A:248 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:248 | A:248 | 63.0 | 0.28 | E | -130.9 | 131.7 | NA | NA | NA | |||||||||||||
| 6u2f | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | ARG | A:248 | A:248 | 56.0 | 0.249 | E | -140.7 | 120.7 | 56.0 | 0.249 | 0.0 | ||||||
| 5vlp | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2017-08-16 | ARG | A:248 | A:248 | 58.0 | 0.258 | E | -131.1 | 122.6 | 58.0 | 0.258 | 0.0 | ||||||
| 6u3i | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | ARG | A:248 | A:248 | 59.0 | 0.262 | E | -129.2 | 121.8 | 59.0 | 0.262 | 0.0 |
HOH |
6.968 |
HH22 |
O |
||
| 6u26 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:218 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:218 | B:248 | 49.0 | 0.218 | E | -131.2 | 131.4 | NA | NA | NA | |||||||||||||
| 6u2n | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:218 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:218 | B:248 | 75.0 | 0.333 | E | -127.0 | 130.8 | 75.0 | 0.333 | 0.0 |
HOH |
4.886 |
CG |
O |
|||||||||
| 6u2p | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:218 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:218 | B:248 | 69.0 | 0.307 | E | -130.6 | 134.1 | 69.0 | 0.307 | 0.0 |
EDO HOH |
6.878 3.483 |
NH1 NE |
O1 O |
|||||||||
| 6u36 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:218 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:218 | B:248 | 41.0 | 0.182 | E | -137.1 | 114.6 | 41.0 | 0.182 | 0.0 | |||||||||||||
| 6u38 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:218 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:218 | B:248 | 65.0 | 0.289 | E | -133.1 | 121.7 | 65.0 | 0.289 | 0.0 |
HOH |
6.149 |
O |
O |
|||||||||
| 6u3x | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:218 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:218 | B:248 | 74.0 | 0.329 | E | -132.4 | 119.2 | 74.0 | 0.329 | 0.0 |
HOH |
4.103 |
NH1 |
O |
|||||||||
| 2pmw | 2 | Q5SZQ2 | 100.0 | 0.0 |
X-RAY |
2007-05-08 | ARG | B:96 | B:248 | 69.0 | 0.307 | E | -123.6 | 138.4 | 69.0 | 0.307 | 0.0 |
HOH |
2.666 |
NH2 |
O |
||
| 3p5b | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | ARG | B:96 | A:248 | 51.0 | 0.227 | E | -120.0 | 124.8 | 51.0 | 0.227 | 0.0 | ||||||
| 3p5c | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | ARG | B:96 | A:248 | 71.0 | 0.316 | E | -120.0 | 124.7 | 71.0 | 0.316 | 0.0 | ||||||
| 3bps | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2008-02-12 | ARG | B:96 | A:248 | 38.0 | 0.169 | E | -124.5 | 129.6 | 38.0 | 0.169 | 0.0 |
HOH |
4.253 |
CG |
O |
||
| 3gcw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | ARG | B:96 | A:248 | 32.0 | 0.142 | E | -126.9 | 120.5 | 32.0 | 0.142 | 0.0 | ||||||
| 3gcx | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | ARG | B:96 | A:248 | 51.0 | 0.227 | E | -126.1 | 122.2 | 51.0 | 0.227 | 0.0 | ||||||
| 3sqo | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2012-05-16 | ARG | A:96 | A:248 | 35.0 | 0.156 | E | -144.3 | 119.5 | 35.0 | 0.156 | 0.0 |
HOH |
5.629 |
CD |
O |
||
| 4ne9 | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2014-09-10 | ARG | A:96 | A:248 | 56.0 | 0.249 | E | -131.9 | 125.1 | 56.0 | 0.249 | 0.0 |
HOH |
3.530 |
CD |
O |
||
| ARG | B:96 | B:248 | 77.0 | 0.342 | E | -132.4 | 121.0 | NA | NA | NA | |||||||||||||
| 4k8r | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2013-05-08 | ARG | B:96 | B:248 | 38.0 | 0.169 | E | -129.2 | 112.8 | 38.0 | 0.169 | 0.0 |
HOH |
6.039 |
O |
O |
||
| 5vl7 | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2017-08-16 | ARG | B:96 | B:248 | 58.0 | 0.258 | E | -139.6 | 122.5 | 58.0 | 0.258 | 0.0 | ||||||
| 2qtw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2007-09-18 | ARG | B:96 | B:248 | 73.0 | 0.324 | E | -128.4 | 135.4 | 73.0 | 0.324 | 0.0 |
HOH |
3.732 |
NE |
O |
||
| 7kev | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-24 | ARG | B:96 | B:248 | 65.0 | 0.289 | E | -121.1 | 142.5 | 65.0 | 0.289 | 0.0 |
HOH |
4.572 |
NE |
O |
||
| 7kfa | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-10 | ARG | B:96 | B:248 | 65.0 | 0.289 | E | -135.5 | 134.7 | 65.0 | 0.289 | 0.0 |
HOH |
2.748 |
NE |
O |
||
| 3m0c | 2 | Q8NBP7 | 99.44 | 0.0 |
X-RAY |
2011-03-16 | ARG | B:96 | B:248 | 73.0 | 0.324 | E | -128.4 | 135.3 | 73.0 | 0.324 | 0.0 | ||||||
| 3h42 | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2009-05-05 | ARG | B:96 | B:248 | 32.0 | 0.142 | E | -127.2 | 126.3 | 32.0 | 0.142 | 0.0 |
HOH |
4.343 |
NH1 |
O |
||
| 5oca | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2017-09-20 | ARG | B:96 | B:248 | 37.0 | 0.164 | E | -128.2 | 125.3 | 37.0 | 0.164 | 0.0 |
HOH |
2.525 |
NH1 |
O |
||
| 5vla | 1 | Q8NBP7 | 99.78 | 0.0 |
X-RAY |
2017-08-16 | ARG | A:248 | A:248 | 78.0 | 0.347 | E | -119.8 | 123.6 | 78.0 | 0.347 | 0.0 |
HOH |
3.204 |
NH2 |
O |
||
| 5vlh | 1 | Q8NBP7 | 99.78 | 0.0 |
X-RAY |
2017-08-16 | ARG | A:248 | A:248 | 60.0 | 0.267 | E | -126.4 | 117.6 | 60.0 | 0.267 | 0.0 | ||||||
| 5vlk | 1 | Q8NBP7 | 99.78 | 0.0 |
X-RAY |
2017-08-16 | ARG | A:248 | A:248 | 75.0 | 0.333 | E | -117.6 | 133.4 | 75.0 | 0.333 | 0.0 |
HOH |
2.616 |
NE |
O |
||
| 5vll | 1 | Q8NBP7 | 99.78 | 0.0 |
X-RAY |
2017-08-16 | ARG | A:248 | A:248 | 64.0 | 0.284 | E | -120.4 | 126.0 | 64.0 | 0.284 | 0.0 |
HOH |
5.818 |
NH1 |
O |
||
| 4nmx | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2013-12-04 | ARG | B:96 | B:248 | 70.0 | 0.311 | E | -127.8 | 129.0 | 70.0 | 0.311 | 0.0 |
HOH |
3.347 |
NH2 |
O |
||
| 6xib | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2020-11-18 | ARG | B:96 | B:248 | 61.0 | 0.271 | E | -128.7 | 126.4 | 61.0 | 0.271 | 0.0 |
HOH |
3.534 |
CD |
O |
||
| 6xic | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2020-11-18 | ARG | B:96 | B:248 | 78.0 | 0.347 | E | -129.7 | 126.1 | 78.0 | 0.347 | 0.0 |
HOH |
2.992 |
NH2 |
O |
||
| 6xid | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2020-11-18 | ARG | B:96 | B:248 | 90.0 | 0.4 | E | -126.7 | 130.4 | 90.0 | 0.4 | 0.0 |
HOH |
3.716 |
CD |
O |
||
| 6xie | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2020-11-18 | ARG | B:96 | B:248 | 85.0 | 0.378 | E | -130.1 | 125.2 | 85.0 | 0.378 | 0.0 |
HOH |
2.890 |
NH2 |
O |
||
| 6xif | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2020-11-18 | ARG | B:96 | B:248 | 83.0 | 0.369 | E | -127.5 | 130.8 | 83.0 | 0.369 | 0.0 |
HOH |
3.012 |
NH2 |
O |
||
| 7s5g | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2021-11-03 | ARG | B:96 | B:248 | 71.0 | 0.316 | E | -134.1 | 127.7 | 71.0 | 0.316 | 0.0 |
HOH |
3.613 |
NH2 |
O |
||
| 7s5h | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2021-11-03 | ARG | B:96 | B:248 | 84.0 | 0.373 | E | -132.0 | 132.8 | 84.0 | 0.373 | 0.0 |
HOH |
2.981 |
NH2 |
O |
||
| 2w2m | 1 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2008-11-18 | ARG | A:96 | A:248 | 41.0 | 0.182 | E | -136.7 | 121.1 | 41.0 | 0.182 | 0.0 |
HOH |
2.935 |
NH1 |
O |
||
| 2w2n | 1 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2008-11-18 | ARG | A:96 | A:248 | 62.0 | 0.276 | E | -133.6 | 127.4 | 62.0 | 0.276 | 0.0 |
HOH |
4.468 |
CG |
O |
||
| 2w2p | 1 | Q8NBP7 | 99.67 | 0.0 |
X-RAY |
2008-11-18 | ARG | A:96 | A:248 | 38.0 | 0.169 | E | -139.7 | 124.4 | 38.0 | 0.169 | 0.0 |
HOH |
5.522 |
NH2 |
O |
||
| 2w2q | 1 | Q8NBP7 | 99.67 | 0.0 |
X-RAY |
2008-11-18 | ARG | A:96 | A:248 | 42.0 | 0.187 | E | -124.7 | 128.9 | 42.0 | 0.187 | 0.0 |
HOH |
3.385 |
CD |
O |
||
| 2w2o | 1 | Q8NBP7 | 99.67 | 0.0 |
X-RAY |
2008-11-18 | ARG | A:96 | A:248 | 47.0 | 0.209 | E | -129.2 | 122.3 | 47.0 | 0.209 | 0.0 | ||||||
| 2xtj | 1 | Q8NBP7 | 99.67 | 0.0 |
X-RAY |
2010-11-03 | ARG | A:96 | A:248 | 72.0 | 0.32 | E | -126.9 | 128.2 | 72.0 | 0.32 | 0.0 |
HOH |
6.175 |
O |
O |
||
| 4ov6 | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2014-07-02 | ARG | B:96 | B:248 | 64.0 | 0.284 | E | -129.3 | 117.6 | 64.0 | 0.284 | 0.0 |
HOH |
3.167 |
NH2 |
O |
||
| ARG | D:96 | E:248 | 29.0 | 0.129 | E | -132.0 | 129.6 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q8nbp7-f1 | 1 | Q8NBP7 | 100.0 | 0.0 | ARG | A:248 | A:248 | 39.0 | 0.173 | E | -128.2 | 120.2 | |