Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55518422 . C A CCDS603.1:NM_174936.3:c.757Ctc>Atc_NP_777596.2:p.253L>I Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 LEU A:253 NA:NA DO NA DO DO DO NA NA NA
LEU B:253 A:253 13.0 0.076 S -116.8 131.5 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 LEU A:253 A:253 0.0 0.0 S -123.4 137.1 0.0 0.0 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 LEU A:253 A:253 0.0 0.0 S -123.2 122.1 0.0 0.0 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 LEU A:253 A:253 0.0 0.0 S -125.2 135.6 0.0 0.0 0.0 HOH
 8.659
 H
 O
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 LEU A:223 NA:NA DO NA DO DO DO NA NA NA
LEU B:223 B:253 13.0 0.076 S -120.3 137.3 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 LEU A:223 NA:NA DO NA DO DO DO NA NA NA
LEU B:223 B:253 12.0 0.071 S -118.9 139.2 0.0 0.0 0.071 A:Q8NBP7:0.071
 HOH
 3.238
 O
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 LEU A:223 NA:NA DO NA DO DO DO NA NA NA
LEU B:223 B:253 13.0 0.076 S -118.4 136.0 0.0 0.0 0.076 A:Q8NBP7:0.076
 HOH
 3.033
 O
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 LEU A:223 NA:NA DO NA DO DO DO NA NA NA
LEU B:223 B:253 12.0 0.071 S -121.1 132.4 0.0 0.0 0.071 A:Q8NBP7:0.071
 HOH
 7.090
 O
 O
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 LEU A:223 NA:NA DO NA DO DO DO NA NA NA
LEU B:223 B:253 14.0 0.082 S -122.2 134.6 0.0 0.0 0.082 A:Q8NBP7:0.082
 HOH
 4.883
 N
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 LEU A:223 NA:NA DO NA DO DO DO NA NA NA
LEU B:223 B:253 13.0 0.076 S -120.1 136.6 0.0 0.0 0.076 A:Q8NBP7:0.076
 HOH
 3.127
 O
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 LEU B:101 B:253 13.0 0.076 S -116.0 138.2 0.0 0.0 0.076 A:Q5SZQ2:0.076
 HOH
 2.992
 O
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 LEU B:101 A:253 22.0 0.129 S -116.6 144.5 0.0 0.0 0.129 A:Q8NBP7:0.129
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 LEU B:101 A:253 21.0 0.124 S -116.5 144.5 0.0 0.0 0.124 A:Q8NBP7:0.124
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 LEU B:101 A:253 12.0 0.071 S -113.5 142.7 0.0 0.0 0.071 A:Q8NBP7:0.071
 HOH
 3.047
 O
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 LEU B:101 A:253 13.0 0.076 S -119.2 135.3 0.0 0.0 0.076 A:Q8NBP7:0.076
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 LEU B:101 A:253 12.0 0.071 S -117.8 139.1 0.0 0.0 0.071 A:Q8NBP7:0.071
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 LEU A:101 A:253 13.0 0.076 S -105.5 145.8 0.0 0.0 0.076 D:Q8NBP7:0.076
 HOH
 4.940
 N
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 LEU A:101 A:253 12.0 0.071 S -116.2 132.1 0.0 0.0 0.071 E:Q8NBP7:0.071
LEU B:101 B:253 13.0 0.076 S -119.1 127.7 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 LEU B:101 B:253 18.0 0.106 B -112.4 140.4 0.0 0.0 0.106 A:Q8NBP7:0.106
 HOH
 6.995
 N
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 LEU B:101 B:253 14.0 0.082 S -106.9 143.8 0.0 0.0 0.082 A:Q8NBP7:0.082
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 LEU B:101 B:253 12.0 0.071 S -120.3 133.5 0.0 0.0 0.071 A:Q8NBP7:0.071
 HOH
 2.838
 O
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 LEU B:101 B:253 14.0 0.082 S -107.4 137.1 0.0 0.0 0.082 A:Q8NBP7:0.082
 HOH
 7.697
 CD2
 O
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 LEU B:101 B:253 13.0 0.076 S -113.7 131.9 0.0 0.0 0.076 A:Q8NBP7:0.076
 HOH
 2.961
 O
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 LEU B:101 B:253 12.0 0.071 S -120.2 133.5 0.0 0.0 0.071 A:Q8NBP7:0.071
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 LEU B:101 B:253 14.0 0.082 S -123.0 136.3 0.0 0.0 0.082 A:Q8NBP7:0.082
 HOH
 3.083
 O
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 LEU B:101 B:253 13.0 0.076 S -121.2 136.5 0.0 0.0 0.076 A:Q8NBP7:0.076
 HOH
 3.176
 O
 O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 LEU A:253 A:253 0.0 0.0 S -111.8 133.5 0.0 0.0 0.0 HOH
 3.036
 O
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 LEU A:253 A:253 0.0 0.0 S -121.1 134.3 0.0 0.0 0.0
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 LEU A:253 A:253 0.0 0.0 S -118.5 136.2 0.0 0.0 0.0 HOH
 3.021
 O
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 LEU A:253 A:253 0.0 0.0 S -116.0 134.5 0.0 0.0 0.0 HOH
 4.929
 N
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 LEU B:101 B:253 11.0 0.065 S -118.4 131.6 0.0 0.0 0.065 A:Q8NBP7:0.065
 HOH
 2.915
 O
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 LEU B:101 B:253 12.0 0.071 S -122.6 133.5 0.0 0.0 0.071 A:Q8NBP7:0.071
 HOH
 3.086
 O
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 LEU B:101 B:253 11.0 0.065 S -116.9 136.1 0.0 0.0 0.065 A:Q8NBP7:0.065
 HOH
 3.060
 O
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 LEU B:101 B:253 13.0 0.076 S -121.9 135.8 0.0 0.0 0.076 A:Q8NBP7:0.076
 HOH
 3.105
 O
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 LEU B:101 B:253 11.0 0.065 S -121.3 134.4 0.0 0.0 0.065 A:Q8NBP7:0.065
 HOH
 3.051
 O
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 LEU B:101 B:253 11.0 0.065 S -119.3 132.9 0.0 0.0 0.065 A:Q8NBP7:0.065
 HOH
 3.027
 O
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 LEU B:101 B:253 11.0 0.065 S -119.6 133.5 0.0 0.0 0.065 A:Q8NBP7:0.065
 HOH
 3.289
 O
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 LEU B:101 B:253 11.0 0.065 S -120.5 137.2 0.0 0.0 0.065 A:Q8NBP7:0.065
 HOH
 3.096
 O
 O
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 LEU A:101 A:253 12.0 0.071 S -122.2 137.1 0.0 0.0 0.071 C:Q8NBP7:0.071
 HOH
 3.197
 O
 O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 LEU A:101 A:253 11.0 0.065 S -119.0 134.9 0.0 0.0 0.065 C:Q8NBP7:0.065
 HOH
 3.269
 O
 O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 LEU A:101 A:253 11.0 0.065 S -121.2 135.8 0.0 0.0 0.065 C:Q8NBP7:0.065
 HOH
 7.236
 CD1
 O
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 LEU A:101 A:253 11.0 0.065 S -120.8 132.2 0.0 0.0 0.065 C:Q8NBP7:0.065
 HOH
 2.989
 O
 O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 LEU A:101 A:253 12.0 0.071 -117.4 138.2 0.0 0.0 0.071 C:Q8NBP7:0.071
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 LEU A:101 A:253 10.0 0.059 S -123.7 140.6 0.0 0.0 0.059 F:Q8NBP7:0.059
 HOH
 2.878
 O
 O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 LEU B:101 B:253 14.0 0.082 S -119.0 130.0 0.0 0.0 0.082 A:Q8NBP7:0.082
 HOH
 2.855
 O
 O
LEU D:101 E:253 15.0 0.088 -124.1 125.8 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 LEU A:253 A:253 0.0 0.0 S -115.2 136.8