Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55518456 . C A CCDS603.1:NM_174936.3:c.791aCc>aAc_NP_777596.2:p.264T>N Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 THR A:264 NA:NA DO NA DO DO DO NA NA NA
THR B:264 A:264 6.0 0.043 H -60.2 -43.8 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 THR A:264 A:264 0.0 0.0 H -64.8 -45.7 0.0 0.0 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 THR A:264 A:264 0.0 0.0 H -68.5 -43.6 0.0 0.0 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 THR A:264 A:264 0.0 0.0 H -66.2 -42.0 0.0 0.0 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 THR A:234 NA:NA DO NA DO DO DO NA NA NA
THR B:234 B:264 5.0 0.036 H -64.6 -44.5 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 THR A:234 NA:NA DO NA DO DO DO NA NA NA
THR B:234 B:264 6.0 0.043 H -67.9 -42.4 0.0 0.0 0.043 A:Q8NBP7:0.043
 HOH
 3.851
 N
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 THR A:234 NA:NA DO NA DO DO DO NA NA NA
THR B:234 B:264 5.0 0.036 H -66.3 -41.2 0.0 0.0 0.036 A:Q8NBP7:0.036
 HOH
 3.838
 N
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 THR A:234 NA:NA DO NA DO DO DO NA NA NA
THR B:234 B:264 5.0 0.036 H -72.0 -38.1 0.0 0.0 0.036 A:Q8NBP7:0.036
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 THR A:234 NA:NA DO NA DO DO DO NA NA NA
THR B:234 B:264 4.0 0.029 H -72.4 -38.1 0.0 0.0 0.029 A:Q8NBP7:0.029
 HOH
 4.224
 N
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 THR A:234 NA:NA DO NA DO DO DO NA NA NA
THR B:234 B:264 5.0 0.036 H -67.8 -38.4 0.0 0.0 0.036 A:Q8NBP7:0.036
 HOH
 9.111
 CG2
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 THR B:112 B:264 6.0 0.043 H -66.9 -37.0 0.0 0.0 0.043 A:Q5SZQ2:0.043
 HOH
 4.138
 N
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 THR B:112 A:264 8.0 0.057 H -74.8 -32.4 1.0 0.007 0.05 A:Q8NBP7:0.05
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 THR B:112 A:264 8.0 0.057 H -74.7 -32.4 1.0 0.007 0.05 A:Q8NBP7:0.05
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 THR B:112 A:264 6.0 0.043 H -66.1 -41.2 0.0 0.0 0.043 A:Q8NBP7:0.043
 HOH
 3.933
 N
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 THR B:112 A:264 6.0 0.043 H -65.2 -41.4 0.0 0.0 0.043 A:Q8NBP7:0.043
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 THR B:112 A:264 6.0 0.043 H -68.4 -37.7 0.0 0.0 0.043 A:Q8NBP7:0.043
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 THR A:112 A:264 6.0 0.043 H -67.4 -37.5 0.0 0.0 0.043 D:Q8NBP7:0.043
 HOH
 4.185
 N
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 THR A:112 A:264 5.0 0.036 H -61.7 -42.4 0.0 0.0 0.036 E:Q8NBP7:0.036
 HOH
 8.668
 N
 O
THR B:112 B:264 5.0 0.036 H -61.8 -43.1 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 THR B:112 B:264 6.0 0.043 H -63.3 -38.0 0.0 0.0 0.043 A:Q8NBP7:0.043
 HOH
 8.111
 O
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 THR B:112 B:264 5.0 0.036 H -56.5 -48.9 0.0 0.0 0.036 A:Q8NBP7:0.036
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 THR B:112 B:264 6.0 0.043 H -66.7 -44.8 0.0 0.0 0.043 A:Q8NBP7:0.043
 HOH
 4.083
 N
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 THR B:112 B:264 4.0 0.029 H -74.4 -30.7 0.0 0.0 0.029 A:Q8NBP7:0.029
 HOH
 9.151
 N
 O
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 THR B:112 B:264 7.0 0.05 H -66.7 -40.8 0.0 0.0 0.05 A:Q8NBP7:0.05
 HOH
 4.356
 N
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 THR B:112 B:264 5.0 0.036 H -66.9 -44.6 0.0 0.0 0.036 A:Q8NBP7:0.036
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 THR B:112 B:264 6.0 0.043 H -66.7 -42.8 0.0 0.0 0.043 A:Q8NBP7:0.043
 HOH
 4.182
 N
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 THR B:112 B:264 6.0 0.043 H -64.2 -41.3 0.0 0.0 0.043 A:Q8NBP7:0.043
 HOH
 4.168
 N
 O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 THR A:264 A:264 0.0 0.0 H -64.8 -41.7 0.0 0.0 0.0 HOH
 3.875
 N
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 THR A:264 A:264 0.0 0.0 H -69.0 -38.5 0.0 0.0 0.0
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 THR A:264 A:264 0.0 0.0 H -67.4 -39.5 0.0 0.0 0.0 HOH
 3.936
 N
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 THR A:264 A:264 0.0 0.0 H -67.3 -43.7 0.0 0.0 0.0 HOH
 4.189
 N
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 THR B:112 B:264 5.0 0.036 H -61.9 -43.2 0.0 0.0 0.036 A:Q8NBP7:0.036
 HOH
 3.977
 N
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 THR B:112 B:264 5.0 0.036 H -64.8 -41.0 0.0 0.0 0.036 A:Q8NBP7:0.036
 HOH
 4.149
 N
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 THR B:112 B:264 5.0 0.036 H -65.8 -40.1 0.0 0.0 0.036 A:Q8NBP7:0.036
 HOH
 4.112
 N
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 THR B:112 B:264 5.0 0.036 H -65.6 -40.7 0.0 0.0 0.036 A:Q8NBP7:0.036
 HOH
 4.106
 N
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 THR B:112 B:264 5.0 0.036 H -67.3 -39.4 0.0 0.0 0.036 A:Q8NBP7:0.036
 HOH
 4.155
 N
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 THR B:112 B:264 5.0 0.036 H -67.1 -39.9 0.0 0.0 0.036 A:Q8NBP7:0.036
 HOH
 4.071
 N
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 THR B:112 B:264 6.0 0.043 H -64.9 -37.4 0.0 0.0 0.043 A:Q8NBP7:0.043
 HOH
 4.389
 N
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 THR B:112 B:264 5.0 0.036 H -64.4 -40.7 0.0 0.0 0.036 A:Q8NBP7:0.036
 HOH
 3.850
 N
 O
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 THR A:112 A:264 6.0 0.043 H -69.1 -43.3 0.0 0.0 0.043 C:Q8NBP7:0.043
 HOH
 4.158
 N
 O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 THR A:112 A:264 7.0 0.05 H -62.8 -38.2 0.0 0.0 0.05 C:Q8NBP7:0.05
 HOH
 4.105
 N
 O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 THR A:112 A:264 6.0 0.043 H -66.4 -46.3 0.0 0.0 0.043 C:Q8NBP7:0.043
 HOH
 7.904
 O
 O
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 THR A:112 A:264 5.0 0.036 H -65.1 -39.5 0.0 0.0 0.036 C:Q8NBP7:0.036
 HOH
 3.984
 N
 O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 THR A:112 A:264 5.0 0.036 H -63.9 -37.5 0.0 0.0 0.036 C:Q8NBP7:0.036
 HOH
 9.071
 N
 O
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 THR A:112 A:264 6.0 0.043 H -61.3 -45.8 0.0 0.0 0.043 F:Q8NBP7:0.043
 HOH
 4.057
 N
 O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 THR B:112 B:264 5.0 0.036 H -68.0 -37.9 0.0 0.0 0.036 A:Q8NBP7:0.036
 HOH
 4.449
 N
 O
THR D:112 E:264 5.0 0.036 H -68.5 -37.2 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 THR A:264 A:264 0.0 0.0 H -61.3 -42.6