Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55521701 . C A CCDS603.1:NM_174936.3:c.835Cct>Act_NP_777596.2:p.279P>T Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 PRO A:279 NA:NA DO NA DO DO DO NA NA NA
PRO B:279 A:279 104.0 0.717 -55.4 138.0 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 PRO A:279 A:279 86.0 0.593 -83.0 -179.2 86.0 0.593 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 PRO A:279 A:279 142.0 0.979 -75.8 360.0 142.0 0.979 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 PRO A:279 A:279 93.0 0.641 -78.6 -171.4 93.0 0.641 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 PRO A:249 NA:NA DO NA DO DO DO NA NA NA
PRO B:249 B:279 94.0 0.648 -61.6 136.7 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 PRO A:249 NA:NA DO NA DO DO DO NA NA NA
PRO B:249 B:279 88.0 0.607 -61.0 143.1 88.0 0.607 0.0 HOH
 2.698
 O
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 PRO A:249 NA:NA DO NA DO DO DO NA NA NA
PRO B:249 B:279 86.0 0.593 -64.4 139.5 86.0 0.593 0.0 EDO
HOH
 5.473
2.773
 O
O
 O1
O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 PRO A:249 NA:NA DO NA DO DO DO NA NA NA
PRO B:249 B:279 107.0 0.738 -65.8 165.9 107.0 0.738 0.0
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 PRO A:249 NA:NA DO NA DO DO DO NA NA NA
PRO B:249 B:279 105.0 0.724 -61.0 155.3 105.0 0.724 0.0
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 PRO A:249 NA:NA DO NA DO DO DO NA NA NA
PRO B:249 B:279 96.0 0.662 -61.4 144.0 96.0 0.662 0.0 HOH
 4.863
 N
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 PRO B:127 B:279 99.0 0.683 -60.8 141.0 99.0 0.683 0.0 HOH
 2.814
 O
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 PRO B:127 A:279 104.0 0.717 -76.2 153.9 104.0 0.717 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 PRO B:127 A:279 132.0 0.91 -70.3 100.2 132.0 0.91 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 PRO B:127 A:279 97.0 0.669 -77.3 93.7 97.0 0.669 0.0 HOH
 5.834
 C
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 PRO B:127 A:279 101.0 0.697 -83.4 100.9 101.0 0.697 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 PRO B:127 A:279 100.0 0.69 -84.5 100.8 100.0 0.69 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 PRO A:127 A:279 96.0 0.662 -72.0 135.2 96.0 0.662 0.0 HOH
 3.767
 C
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 PRO A:127 A:279 104.0 0.717 -65.2 119.4 104.0 0.717 0.0
PRO B:127 B:279 109.0 0.752 -65.1 141.2 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 PRO B:127 B:279 125.0 0.862 -73.0 143.4 125.0 0.862 0.0
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 PRO B:127 B:279 97.0 0.669 -58.0 113.5 97.0 0.669 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 PRO B:127 B:279 101.0 0.697 -62.3 137.2 101.0 0.697 0.0 HOH
 2.927
 O
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 PRO B:127 B:279 97.0 0.669 -54.2 156.2 97.0 0.669 0.0
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 PRO B:127 B:279 96.0 0.662 -59.3 144.6 96.0 0.662 0.0 HOH
 4.564
 CG
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 PRO B:127 B:279 99.0 0.683 -62.2 137.1 99.0 0.683 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 PRO B:127 B:279 120.0 0.828 -63.3 114.5 120.0 0.828 0.0 HOH
 5.573
 O
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 PRO B:127 B:279 122.0 0.841 -60.2 142.6 122.0 0.841 0.0 HOH
 6.388
 O
 O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 PRO A:279 A:279 97.0 0.669 -63.6 145.0 97.0 0.669 0.0 HOH
 2.787
 O
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 PRO A:279 A:279 98.0 0.676 -64.9 143.1 98.0 0.676 0.0
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 PRO A:279 A:279 97.0 0.669 -59.1 139.2 97.0 0.669 0.0 HOH
 2.769
 O
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 PRO A:279 A:279 96.0 0.662 -59.8 145.6 96.0 0.662 0.0 HOH
 2.732
 O
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 PRO B:127 B:279 94.0 0.648 -66.5 141.2 94.0 0.648 0.0 HOH
 2.784
 O
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 PRO B:127 B:279 94.0 0.648 -65.1 142.5 94.0 0.648 0.0 HOH
 2.672
 O
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 PRO B:127 B:279 94.0 0.648 -65.2 143.6 94.0 0.648 0.0 HOH
 2.737
 O
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 PRO B:127 B:279 93.0 0.641 -64.2 141.9 93.0 0.641 0.0 HOH
 2.781
 O
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 PRO B:127 B:279 95.0 0.655 -65.7 141.9 95.0 0.655 0.0 HOH
 2.788
 O
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 PRO B:127 B:279 97.0 0.669 -63.2 143.3 97.0 0.669 0.0 HOH
 2.727
 O
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 PRO B:127 B:279 94.0 0.648 -68.5 138.1 94.0 0.648 0.0 HOH
 3.888
 C
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 PRO B:127 NA:NA DO NA DO DO DO NA NA NA
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 PRO A:127 A:279 92.0 0.634 -86.0 151.8 92.0 0.634 0.0 HOH
 4.037
 CB
 O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 PRO A:127 A:279 79.0 0.545 -87.4 -178.0 79.0 0.545 0.0 HOH
 8.192
 CB
 O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 PRO A:127 A:279 85.0 0.586 -82.7 142.3 85.0 0.586 0.0
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 PRO A:127 A:279 80.0 0.552 -96.0 168.4 80.0 0.552 0.0 HOH
 9.887
 N
 O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 PRO A:127 A:279 74.0 0.51 -99.9 173.4 74.0 0.51 0.0
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 PRO A:127 A:279 82.0 0.566 -88.0 167.3 82.0 0.566 0.0 HOH
 8.690
 CB
 O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 PRO B:127 B:279 118.0 0.814 -68.3 151.7 118.0 0.814 0.0
PRO D:127 E:279 111.0 0.766 -67.8 152.9 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 PRO A:279 A:279 124.0 0.855 -55.9 148.5