Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55521758 . A C CCDS603.1:NM_174936.3:c.892Aac>Cac_NP_777596.2:p.298N>H Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 ASN A:298 NA:NA DO NA DO DO DO NA NA NA
ASN B:298 A:298 6.0 0.037 H -62.4 -41.9 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ASN A:298 A:298 14.0 0.087 H -65.1 -39.4 14.0 0.087 0.0 HOH
 3.013
 HB2
 O
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 ASN A:298 A:298 16.0 0.1 H -63.2 -39.9 16.0 0.1 0.0 NA
 8.231
 ND2
 NA
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ASN A:298 A:298 15.0 0.094 H -62.3 -36.9 15.0 0.094 0.0 HOH
 6.922
 C
 O
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASN A:268 NA:NA DO NA DO DO DO NA NA NA
ASN B:268 B:298 15.0 0.094 H -63.2 -38.7 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASN A:268 NA:NA DO NA DO DO DO NA NA NA
ASN B:268 B:298 12.0 0.075 H -66.6 -36.6 12.0 0.075 0.0 PV7
HOH
 6.382
3.478
 ND2
ND2
 C18
O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASN A:268 NA:NA DO NA DO DO DO NA NA NA
ASN B:268 B:298 13.0 0.081 H -65.8 -38.4 13.0 0.081 0.0 PUV
HOH
 6.310
2.717
 ND2
O
 C18
O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASN A:268 NA:NA DO NA DO DO DO NA NA NA
ASN B:268 B:298 16.0 0.1 H -71.0 -33.1 16.0 0.1 0.0 PVM
HOH
 6.807
7.718
 ND2
ND2
 C25
O
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASN A:268 NA:NA DO NA DO DO DO NA NA NA
ASN B:268 B:298 14.0 0.087 H -73.3 -31.3 14.0 0.087 0.0 PVJ
HOH
 7.107
7.470
 ND2
ND2
 C25
O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASN A:268 NA:NA DO NA DO DO DO NA NA NA
ASN B:268 B:298 11.0 0.069 H -68.0 -35.2 11.0 0.069 0.0 PVV
HOH
 6.616
3.792
 ND2
CB
 C16
O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 ASN B:146 B:298 14.0 0.087 H -68.3 -39.9 14.0 0.087 0.0 HOH
 3.177
 ND2
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ASN B:146 A:298 18.0 0.113 H -70.0 -35.0 18.0 0.113 0.0 CA
 8.696
 OD1
 CA
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ASN B:146 A:298 19.0 0.119 H -70.1 -34.8 19.0 0.119 0.0 CA
 8.696
 OD1
 CA
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 ASN B:146 A:298 20.0 0.125 H -62.0 -33.8 20.0 0.125 0.0 HOH
 2.907
 OD1
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ASN B:146 A:298 16.0 0.1 H -68.4 -36.8 16.0 0.1 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ASN B:146 A:298 16.0 0.1 H -65.2 -39.0 16.0 0.1 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 ASN A:146 A:298 14.0 0.087 H -67.3 -34.9 14.0 0.087 0.0 HOH
 4.134
 CB
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 ASN A:146 A:298 16.0 0.1 H -63.6 -42.6 16.0 0.1 0.0 HOH
 6.950
 C
 O
ASN B:146 B:298 15.0 0.094 H -63.3 -44.2 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 ASN B:146 B:298 15.0 0.094 H -71.8 -41.5 15.0 0.094 0.0 HOH
 7.037
 C
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 ASN B:146 B:298 18.0 0.113 H -60.9 -37.7 18.0 0.113 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 ASN B:146 B:298 13.0 0.081 H -58.8 -37.8 13.0 0.081 0.0 CA
HOH
 8.703
2.979
 OD1
ND2
 CA
O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 ASN B:146 B:298 9.0 0.056 H -69.0 -33.9 9.0 0.056 0.0 CA
HOH
 8.916
3.739
 ND2
CB
 CA
O
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 ASN B:146 B:298 8.0 0.05 H -66.9 -38.6 8.0 0.05 0.0 CA
HOH
 8.441
3.826
 ND2
C
 CA
O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 ASN B:146 B:298 14.0 0.087 H -58.8 -37.7 14.0 0.087 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 ASN B:146 B:298 15.0 0.094 H -61.9 -38.8 15.0 0.094 0.0 NA
HOH
 8.332
2.891
 ND2
ND2
 NA
O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 ASN B:146 B:298 16.0 0.1 H -63.8 -38.7 16.0 0.1 0.0 NA
HOH
 8.528
2.855
 ND2
ND2
 NA
O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASN A:298 A:298 11.0 0.069 H -68.1 -40.0 11.0 0.069 0.0 HOH
 3.375
 ND2
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASN A:298 A:298 12.0 0.075 H -70.4 -46.9 12.0 0.075 0.0 CA
 9.883
 ND2
 CA
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASN A:298 A:298 11.0 0.069 H -64.1 -39.3 11.0 0.069 0.0 HOH
 3.354
 ND2
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASN A:298 A:298 11.0 0.069 H -67.9 -41.5 11.0 0.069 0.0 HOH
 3.789
 CB
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 ASN B:146 B:298 10.0 0.062 H -59.6 -43.1 10.0 0.062 0.0 HOH
 3.008
 ND2
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASN B:146 B:298 13.0 0.081 H -64.8 -40.1 13.0 0.081 0.0 HOH
 3.165
 O
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASN B:146 B:298 15.0 0.094 H -63.7 -41.4 15.0 0.094 0.0 HOH
 3.195
 O
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASN B:146 B:298 13.0 0.081 H -65.3 -39.1 13.0 0.081 0.0 HOH
 3.082
 ND2
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASN B:146 B:298 14.0 0.087 H -63.9 -41.0 14.0 0.087 0.0 HOH
 3.170
 O
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASN B:146 B:298 14.0 0.087 H -67.9 -38.4 14.0 0.087 0.0 HOH
 2.997
 O
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ASN B:146 B:298 15.0 0.094 H -66.3 -37.8 15.0 0.094 0.0 HOH
 6.582
 ND2
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ASN B:146 B:298 20.0 0.125 H -65.9 -40.4 20.0 0.125 0.0 HOH
 2.922
 ND2
 O
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ASN A:146 A:298 10.0 0.062 H -58.8 -40.4 10.0 0.062 0.0 CA
HOH
 8.612
3.203
 ND2
O
 CA
O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ASN A:146 A:298 18.0 0.113 H -65.1 -34.3 18.0 0.113 0.0 CA
HOH
 8.113
3.128
 ND2
ND2
 CA
O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ASN A:146 A:298 16.0 0.1 H -57.9 -44.6 16.0 0.1 0.0 HOH
 7.541
 OD1
 O
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ASN A:146 A:298 18.0 0.113 H -58.6 -42.0 18.0 0.113 0.0 CA
HOH
 8.173
3.697
 ND2
CB
 CA
O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ASN A:146 A:298 12.0 0.075 H -67.5 -43.6 12.0 0.075 0.0 HOH
 8.284
 OD1
 O
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 ASN A:146 A:298 17.0 0.106 H -51.1 -32.7 17.0 0.106 0.0 CA
HOH
 8.311
2.790
 ND2
O
 CA
O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 ASN B:146 B:298 17.0 0.106 H -67.1 -33.5 17.0 0.106 0.0 HOH
 7.910
 OD1
 O
ASN D:146 E:298 18.0 0.113 H -66.9 -33.9 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 ASN A:298 A:298 15.0 0.094 H -63.4 -41.0