Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55521794 . G A CCDS603.1:NM_174936.3:c.928Gtg>Atg_NP_777596.2:p.310V>M Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 VAL A:310 NA:NA DO NA DO DO DO NA NA NA
VAL B:310 A:310 9.0 0.058 E -93.4 118.8 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 VAL A:310 A:310 7.0 0.045 E -99.2 107.3 7.0 0.045 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 VAL A:310 A:310 7.0 0.045 E -91.5 103.3 7.0 0.045 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 VAL A:310 A:310 5.0 0.032 E -101.6 109.9 5.0 0.032 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:280 NA:NA DO NA DO DO DO NA NA NA
VAL B:280 B:310 10.0 0.065 E -91.9 125.6 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:280 NA:NA DO NA DO DO DO NA NA NA
VAL B:280 B:310 10.0 0.065 E -94.1 117.5 10.0 0.065 0.0 HOH
 3.649
 CA
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:280 NA:NA DO NA DO DO DO NA NA NA
VAL B:280 B:310 10.0 0.065 E -94.5 122.5 10.0 0.065 0.0 HOH
 3.443
 CA
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:280 NA:NA DO NA DO DO DO NA NA NA
VAL B:280 B:310 7.0 0.045 E -96.3 110.1 7.0 0.045 0.0 HOH
 8.957
 N
 O
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:280 NA:NA DO NA DO DO DO NA NA NA
VAL B:280 B:310 5.0 0.032 E -93.8 109.4 5.0 0.032 0.0 HOH
 7.935
 CG2
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:280 NA:NA DO NA DO DO DO NA NA NA
VAL B:280 B:310 11.0 0.071 E -86.8 124.6 11.0 0.071 0.0 HOH
 9.712
 CG2
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 VAL B:158 B:310 12.0 0.077 E -98.2 123.1 12.0 0.077 0.0 HOH
 3.477
 CA
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 VAL B:158 A:310 9.0 0.058 E -87.1 122.7 9.0 0.058 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 VAL B:158 A:310 8.0 0.052 E -87.2 122.8 8.0 0.052 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 VAL B:158 A:310 4.0 0.026 E -98.0 110.0 4.0 0.026 0.0 HOH
 3.834
 CA
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 VAL B:158 A:310 4.0 0.026 E -96.2 117.4 4.0 0.026 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 VAL B:158 A:310 4.0 0.026 E -92.7 117.7 4.0 0.026 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 VAL A:158 A:310 7.0 0.045 E -86.5 129.1 7.0 0.045 0.0 HOH
 8.471
 CG1
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 VAL A:158 A:310 4.0 0.026 E -93.4 113.2 4.0 0.026 0.0
VAL B:158 B:310 4.0 0.026 E -100.1 107.6 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 VAL B:158 B:310 3.0 0.019 E -97.2 108.8 3.0 0.019 0.0 HOH
 3.896
 C
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 VAL B:158 B:310 5.0 0.032 E -83.5 104.8 5.0 0.032 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 VAL B:158 B:310 12.0 0.077 E -90.5 129.5 12.0 0.077 0.0 HOH
 3.217
 CG2
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 VAL B:158 B:310 8.0 0.052 E -91.6 118.4 8.0 0.052 0.0 HOH
 3.556
 C
 O
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 VAL B:158 B:310 7.0 0.045 E -98.7 124.1 7.0 0.045 0.0 HOH
 3.667
 CA
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 VAL B:158 B:310 11.0 0.071 E -90.5 129.5 11.0 0.071 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 VAL B:158 B:310 5.0 0.032 E -91.8 111.4 5.0 0.032 0.0 HOH
 3.676
 C
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 VAL B:158 B:310 5.0 0.032 E -90.5 109.8 5.0 0.032 0.0 HOH
 3.607
 C
 O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 VAL A:310 A:310 6.0 0.039 E -83.6 126.7 6.0 0.039 0.0 HOH
 3.710
 C
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 VAL A:310 A:310 7.0 0.045 E -86.2 125.3 7.0 0.045 0.0
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 VAL A:310 A:310 10.0 0.065 E -91.9 129.4 10.0 0.065 0.0 HOH
 3.703
 CA
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 VAL A:310 A:310 8.0 0.052 E -91.8 124.9 8.0 0.052 0.0 HOH
 3.621
 CA
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 VAL B:158 B:310 13.0 0.084 E -96.3 122.5 13.0 0.084 0.0 HOH
 3.215
 CG2
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 VAL B:158 B:310 11.0 0.071 E -88.2 124.2 11.0 0.071 0.0 HOH
 3.390
 CG2
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 VAL B:158 B:310 11.0 0.071 E -88.5 126.5 11.0 0.071 0.0 HOH
 3.668
 N
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 VAL B:158 B:310 12.0 0.077 E -90.3 126.9 12.0 0.077 0.0 HOH
 3.674
 CA
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 VAL B:158 B:310 11.0 0.071 E -89.4 127.0 11.0 0.071 0.0 HOH
 3.353
 CG2
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 VAL B:158 B:310 12.0 0.077 E -90.4 125.7 12.0 0.077 0.0 HOH
 3.412
 CG2
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 VAL B:158 B:310 10.0 0.065 E -84.5 130.8 10.0 0.065 0.0 HOH
 5.228
 N
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 VAL B:158 B:310 5.0 0.032 E -95.6 113.5 5.0 0.032 0.0 HOH
 3.543
 CA
 O
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 VAL A:158 A:310 7.0 0.045 E -90.2 112.1 7.0 0.045 0.0 HOH
 3.423
 CA
 O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 VAL A:158 A:310 7.0 0.045 E -92.6 108.3 7.0 0.045 0.0 HOH
 4.094
 CG2
 O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 VAL A:158 A:310 6.0 0.039 E -90.3 114.4 6.0 0.039 0.0 HOH
 4.047
 CG2
 O
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 VAL A:158 A:310 7.0 0.045 E -97.3 106.2 7.0 0.045 0.0 HOH
 3.547
 CA
 O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 VAL A:158 A:310 7.0 0.045 E -99.5 106.5 7.0 0.045 0.0
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 VAL A:158 A:310 5.0 0.032 E -88.9 116.5 5.0 0.032 0.0 HOH
 3.765
 CA
 O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 VAL B:158 B:310 3.0 0.019 E -93.1 112.3 3.0 0.019 0.0
VAL D:158 E:310 3.0 0.019 E -93.7 112.1 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 VAL A:310 A:310 4.0 0.026 E -90.2 106.5