Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55521834 . G A CCDS603.1:NM_174936.3:c.968tGc>tAc_NP_777596.2:p.323C>Y Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 CYS A:323 NA:NA DO NA DO DO DO NA NA NA
CYS B:323 A:323 18.0 0.133 G -60.0 -15.9 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 CYS A:323 A:323 17.0 0.126 G -71.5 -13.0 17.0 0.126 0.0 HOH
 7.906
 HB2
 O
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 CYS A:323 A:323 24.0 0.178 G -67.9 -22.1 24.0 0.178 0.0 NA
 7.551
 SG
 NA
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 CYS A:323 A:323 23.0 0.17 G -75.1 -14.2 23.0 0.17 0.0 HOH
 6.913
 HA
 O
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 CYS A:293 NA:NA DO NA DO DO DO NA NA NA
CYS B:293 B:323 20.0 0.148 G -62.5 -20.5 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 CYS A:293 NA:NA DO NA DO DO DO NA NA NA
CYS B:293 B:323 21.0 0.156 G -57.6 -25.9 21.0 0.156 0.0 PV7
HOH
 5.139
3.282
 SG
SG
 C18
O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 CYS A:293 NA:NA DO NA DO DO DO NA NA NA
CYS B:293 B:323 21.0 0.156 G -62.2 -18.9 21.0 0.156 0.0 PUV
HOH
 5.137
3.237
 SG
N
 O
O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 CYS A:293 NA:NA DO NA DO DO DO NA NA NA
CYS B:293 B:323 22.0 0.163 G -67.8 -19.0 22.0 0.163 0.0 PVM
HOH
 4.924
7.601
 SG
O
 O
O
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 CYS A:293 NA:NA DO NA DO DO DO NA NA NA
CYS B:293 B:323 20.0 0.148 G -72.4 -15.8 20.0 0.148 0.0 PVJ
HOH
 5.044
4.327
 SG
SG
 O
O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 CYS A:293 NA:NA DO NA DO DO DO NA NA NA
CYS B:293 B:323 16.0 0.119 G -67.2 -19.7 16.0 0.119 0.0 PVV
HOH
 5.037
3.086
 SG
SG
 C16
O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 CYS B:171 B:323 16.0 0.119 G -63.8 -14.3 16.0 0.119 0.0 HOH
 3.419
 N
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 CYS B:171 A:323 20.0 0.148 G -75.8 -11.8 20.0 0.148 0.0 CA
 7.452
 SG
 CA
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 CYS B:171 A:323 20.0 0.148 G -75.7 -11.8 20.0 0.148 0.0 CA
 7.451
 SG
 CA
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 CYS B:171 A:323 19.0 0.141 G -62.6 -14.7 19.0 0.141 0.0 HOH
 2.761
 O
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 CYS B:171 A:323 22.0 0.163 G -57.2 -16.9 22.0 0.163 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 CYS B:171 A:323 18.0 0.133 G -61.4 -12.1 18.0 0.133 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 CYS A:171 A:323 17.0 0.126 G -60.5 -14.0 17.0 0.126 0.0 HOH
 3.184
 SG
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 CYS A:171 A:323 22.0 0.163 G -65.1 -16.5 22.0 0.163 0.0 HOH
 8.848
 N
 O
CYS B:171 B:323 20.0 0.148 G -65.1 -16.2 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 CYS B:171 B:323 14.0 0.104 G -63.7 -6.5 14.0 0.104 0.0 HOH
 4.083
 CB
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 CYS B:171 B:323 18.0 0.133 G -58.7 -7.2 18.0 0.133 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 CYS B:171 B:323 15.0 0.111 G -65.1 -12.4 15.0 0.111 0.0 CA
HOH
 7.860
2.560
 SG
O
 CA
O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 CYS B:171 B:323 11.0 0.081 G -64.2 -15.6 11.0 0.081 0.0 CA
HOH
 7.706
5.598
 SG
SG
 CA
O
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 CYS B:171 B:323 18.0 0.133 G -63.5 -15.3 18.0 0.133 0.0 CA
HOH
 7.491
3.367
 SG
SG
 CA
O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 CYS B:171 B:323 15.0 0.111 G -65.1 -12.5 15.0 0.111 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 CYS B:171 B:323 18.0 0.133 G -76.1 -3.4 18.0 0.133 0.0 NA
HOH
 7.380
3.182
 SG
O
 NA
O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 CYS B:171 B:323 19.0 0.141 G -73.6 -6.0 19.0 0.141 0.0 NA
HOH
 7.655
3.084
 SG
O
 NA
O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 CYS A:323 A:323 13.0 0.096 G -63.6 -18.2 13.0 0.096 0.0 CA
HOH
 9.285
3.302
 SG
SG
 CA
O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 CYS A:323 A:323 15.0 0.111 G -77.1 -7.2 15.0 0.111 0.0 CA
 8.683
 SG
 CA
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 CYS A:323 A:323 12.0 0.089 G -65.3 -14.7 12.0 0.089 0.0 CA
HOH
 9.181
2.825
 SG
O
 CA
O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 CYS A:323 A:323 17.0 0.126 G -66.0 -13.1 17.0 0.126 0.0 CA
HOH
 9.201
2.631
 SG
O
 CA
O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 CYS B:171 B:323 16.0 0.119 G -65.2 -13.7 16.0 0.119 0.0 HOH
 2.643
 O
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 CYS B:171 B:323 16.0 0.119 G -64.5 -13.6 16.0 0.119 0.0 HOH
 2.696
 O
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 CYS B:171 B:323 15.0 0.111 G -65.8 -13.8 15.0 0.111 0.0 HOH
 2.715
 O
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 CYS B:171 B:323 16.0 0.119 G -65.0 -14.6 16.0 0.119 0.0 HOH
 2.693
 O
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 CYS B:171 B:323 14.0 0.104 G -62.5 -16.3 14.0 0.104 0.0 HOH
 2.801
 O
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 CYS B:171 B:323 14.0 0.104 G -61.3 -15.0 14.0 0.104 0.0 HOH
 2.668
 O
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 CYS B:171 B:323 13.0 0.096 G -73.6 -13.0 13.0 0.096 0.0 HOH
 2.738
 O
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 CYS B:171 B:323 23.0 0.17 G -63.7 -16.7 23.0 0.17 0.0 HOH
 2.637
 O
 O
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 CYS A:171 A:323 18.0 0.133 G -71.1 -10.8 18.0 0.133 0.0 CA
HOH
 7.827
2.809
 SG
O
 CA
O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 CYS A:171 A:323 17.0 0.126 G -70.7 -14.7 17.0 0.126 0.0 CA
HOH
 7.822
3.017
 SG
SG
 CA
O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 CYS A:171 A:323 17.0 0.126 G -68.2 -13.9 17.0 0.126 0.0 HOH
 7.531
 SG
 O
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 CYS A:171 A:323 18.0 0.133 G -72.1 -9.4 18.0 0.133 0.0 CA
HOH
 7.930
3.138
 SG
SG
 CA
O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 CYS A:171 A:323 18.0 0.133 G -61.5 -13.6 18.0 0.133 0.0 HOH
 7.842
 SG
 O
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 CYS A:171 A:323 21.0 0.156 G -53.0 -20.0 21.0 0.156 0.0 CA
HOH
 8.756
2.912
 SG
O
 CA
O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 CYS B:171 B:323 24.0 0.178 G -65.5 -26.8 24.0 0.178 0.0 HOH
 4.519
 SG
 O
CYS D:171 E:323 24.0 0.178 G -65.8 -27.3 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 CYS A:323 A:323 15.0 0.111 G -66.3 -13.7