Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55523068 . A C CCDS603.1:NM_174936.3:c.1061aAc>aCc_NP_777596.2:p.354N>T Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 ASN A:354 NA:NA DO NA DO DO DO NA NA NA
ASN B:354 A:354 0.0 0.0 -63.2 167.1 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ASN A:354 A:354 0.0 0.0 -75.8 167.4 0.0 0.0 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 ASN A:354 A:354 0.0 0.0 -76.6 156.5 0.0 0.0 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ASN A:354 A:354 0.0 0.0 -77.0 170.8 0.0 0.0 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASN A:324 NA:NA DO NA DO DO DO NA NA NA
ASN B:324 B:354 0.0 0.0 -74.4 165.9 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASN A:324 NA:NA DO NA DO DO DO NA NA NA
ASN B:324 B:354 0.0 0.0 -83.1 162.2 0.0 0.0 0.0 HOH
 6.387
 C
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASN A:324 NA:NA DO NA DO DO DO NA NA NA
ASN B:324 B:354 0.0 0.0 -76.8 167.1 0.0 0.0 0.0 HOH
 6.280
 C
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASN A:324 NA:NA DO NA DO DO DO NA NA NA
ASN B:324 B:354 0.0 0.0 -85.0 170.5 0.0 0.0 0.0 HOH
 9.817
 OD1
 O
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASN A:324 NA:NA DO NA DO DO DO NA NA NA
ASN B:324 B:354 0.0 0.0 -85.6 166.8 0.0 0.0 0.0 HOH
 6.827
 OD1
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASN A:324 NA:NA DO NA DO DO DO NA NA NA
ASN B:324 B:354 0.0 0.0 -82.5 161.8 0.0 0.0 0.0 HOH
 6.291
 C
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 ASN B:202 B:354 0.0 0.0 -71.1 171.3 0.0 0.0 0.0 HOH
 6.416
 C
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ASN B:202 A:354 0.0 0.0 -74.5 157.6 0.0 0.0 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ASN B:202 A:354 0.0 0.0 -74.6 157.6 0.0 0.0 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 ASN B:202 A:354 0.0 0.0 -76.9 167.9 0.0 0.0 0.0 HOH
 6.490
 C
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ASN B:202 A:354 0.0 0.0 -79.5 171.3 0.0 0.0 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ASN B:202 A:354 0.0 0.0 -81.8 168.0 0.0 0.0 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 ASN A:202 A:354 0.0 0.0 -75.2 169.3 0.0 0.0 0.0 HOH
 6.407
 C
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 ASN A:202 A:354 0.0 0.0 -71.4 167.7 0.0 0.0 0.0 HOH
 6.924
 ND2
 O
ASN B:202 B:354 0.0 0.0 -73.9 167.3 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 ASN B:202 B:354 0.0 0.0 -85.3 167.1 0.0 0.0 0.0 HOH
 7.191
 ND2
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 ASN B:202 B:354 0.0 0.0 -76.9 163.9 0.0 0.0 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 ASN B:202 B:354 0.0 0.0 -68.5 170.7 0.0 0.0 0.0 HOH
 6.462
 C
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 ASN B:202 B:354 0.0 0.0 -81.1 168.6 0.0 0.0 0.0 HOH
 7.595
 C
 O
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 ASN B:202 B:354 0.0 0.0 -68.6 172.2 0.0 0.0 0.0 HOH
 5.581
 N
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 ASN B:202 B:354 0.0 0.0 -68.4 170.6 0.0 0.0 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 ASN B:202 B:354 0.0 0.0 -72.5 168.5 0.0 0.0 0.0 HOH
 6.394
 OD1
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 ASN B:202 B:354 0.0 0.0 -66.9 170.6 0.0 0.0 0.0 HOH
 6.432
 C
 O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASN A:354 A:354 0.0 0.0 -76.8 162.5 0.0 0.0 0.0 HOH
 6.158
 OD1
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASN A:354 A:354 0.0 0.0 -84.9 172.0 0.0 0.0 0.0
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASN A:354 A:354 0.0 0.0 -68.4 168.2 0.0 0.0 0.0 HOH
 6.124
 OD1
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASN A:354 A:354 0.0 0.0 -75.9 164.2 0.0 0.0 0.0 HOH
 6.886
 ND2
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 ASN B:202 B:354 0.0 0.0 -73.0 170.8 0.0 0.0 0.0 HOH
 6.286
 C
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASN B:202 B:354 0.0 0.0 -74.2 167.4 0.0 0.0 0.0 HOH
 6.313
 C
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASN B:202 B:354 0.0 0.0 -74.1 167.3 0.0 0.0 0.0 HOH
 6.359
 C
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASN B:202 B:354 0.0 0.0 -73.2 170.2 0.0 0.0 0.0 HOH
 6.349
 C
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASN B:202 B:354 0.0 0.0 -73.0 171.3 0.0 0.0 0.0 HOH
 6.356
 CB
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASN B:202 B:354 0.0 0.0 -75.5 168.7 0.0 0.0 0.0 HOH
 6.359
 C
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ASN B:202 B:354 0.0 0.0 -79.3 168.4 0.0 0.0 0.0 HOH
 6.341
 C
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ASN B:202 B:354 0.0 0.0 -71.8 164.3 0.0 0.0 0.0 HOH
 4.980
 N
 O
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ASN A:202 A:354 0.0 0.0 -73.9 164.9 0.0 0.0 0.0 HOH
 6.211
 OD1
 O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ASN A:202 A:354 0.0 0.0 -73.1 165.5 0.0 0.0 0.0 HOH
 6.516
 C
 O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ASN A:202 A:354 0.0 0.0 -75.0 167.0 0.0 0.0 0.0 HOH
 6.900
 ND2
 O
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ASN A:202 A:354 0.0 0.0 -67.8 162.1 0.0 0.0 0.0 HOH
 6.579
 C
 O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ASN A:202 A:354 0.0 0.0 -76.8 163.5 0.0 0.0 0.0
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 ASN A:202 A:354 0.0 0.0 -77.1 166.6 0.0 0.0 0.0 HOH
 5.719
 O
 O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 ASN B:202 B:354 0.0 0.0 -76.8 165.8 0.0 0.0 0.0 EDO
HOH
 7.228
6.231
 OD1
OD1
 C1
O
ASN D:202 E:354 0.0 0.0 -76.0 165.9 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 ASN A:354 A:354 0.0 0.0 -66.7 164.5