Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55523076 . C A CCDS603.1:NM_174936.3:c.1069Cgc>Agc_NP_777596.2:p.357R>S Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 ARG A:357 NA:NA DO NA DO DO DO NA NA NA
ARG B:357 A:357 90.0 0.4 T -67.2 -19.6 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ARG A:357 A:357 97.0 0.431 T -61.4 -27.7 97.0 0.431 0.0 HOH
 6.068
 HE
 O
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 ARG A:357 A:357 96.0 0.427 T -37.8 -48.2 96.0 0.427 0.0 NA
 5.909
 O
 NA
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ARG A:357 A:357 102.0 0.453 T -54.2 -29.6 102.0 0.453 0.0 HOH
 2.855
 O
 O
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:327 NA:NA DO NA DO DO DO NA NA NA
ARG B:327 B:357 92.0 0.409 T -69.3 -14.7 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:327 NA:NA DO NA DO DO DO NA NA NA
ARG B:327 B:357 94.0 0.418 T -61.7 -16.4 94.0 0.418 0.0 PV7
HOH
 2.841
3.045
 NH1
N
 O19
O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:327 NA:NA DO NA DO DO DO NA NA NA
ARG B:327 B:357 91.0 0.404 T -65.2 -14.3 91.0 0.404 0.0 PUV
HOH
 3.014
2.979
 NH1
N
 O19
O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:327 NA:NA DO NA DO DO DO NA NA NA
ARG B:327 B:357 93.0 0.413 T -68.2 -20.7 93.0 0.413 0.0 PVM
 2.906
 NH2
 N31
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:327 NA:NA DO NA DO DO DO NA NA NA
ARG B:327 B:357 92.0 0.409 T -67.5 -20.1 92.0 0.409 0.0 PVJ
HOH
 2.768
3.155
 NH2
N
 O27
O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:327 NA:NA DO NA DO DO DO NA NA NA
ARG B:327 B:357 99.0 0.44 T -60.9 -21.7 99.0 0.44 0.0 PVV
HOH
 2.772
3.361
 NH1
N
 O1
O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 ARG B:205 B:357 89.0 0.396 T -77.2 -9.6 89.0 0.396 0.0 HOH
 3.108
 N
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ARG B:205 A:357 94.0 0.418 S -73.9 -22.7 94.0 0.418 0.0 CA
 5.763
 O
 CA
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ARG B:205 A:357 95.0 0.422 S -74.0 -22.8 95.0 0.422 0.0 CA
 5.762
 O
 CA
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 ARG B:205 A:357 92.0 0.409 T -71.5 -10.9 92.0 0.409 0.0 HOH
 2.812
 O
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ARG B:205 A:357 93.0 0.413 T -59.3 -23.0 93.0 0.413 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ARG B:205 A:357 93.0 0.413 T -57.8 -23.0 93.0 0.413 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 ARG A:205 A:357 102.0 0.453 T -70.2 -25.3 102.0 0.453 0.0 HOH
 3.119
 N
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 ARG A:205 A:357 92.0 0.409 T -62.1 -20.2 92.0 0.409 0.0 HOH
 9.579
 O
 O
ARG B:205 B:357 93.0 0.413 T -61.5 -20.4 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 ARG B:205 B:357 95.0 0.422 T -15.0 -47.7 95.0 0.422 0.0 HOH
 2.770
 NH1
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 ARG B:205 B:357 91.0 0.404 T -70.2 -6.6 91.0 0.404 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 ARG B:205 B:357 80.0 0.356 T -77.1 -14.9 80.0 0.356 0.0 CA
HOH
 6.023
2.824
 O
O
 CA
O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 ARG B:205 B:357 97.0 0.431 T -62.9 -18.9 97.0 0.431 0.0 CA
HOH
 5.368
5.201
 O
O
 CA
O
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 ARG B:205 B:357 97.0 0.431 T -71.3 -12.5 97.0 0.431 0.0 CA
HOH
 5.739
2.928
 O
NH2
 CA
O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 ARG B:205 B:357 95.0 0.422 T -76.9 -15.0 95.0 0.422 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 ARG B:205 B:357 88.0 0.391 T -72.3 -13.2 88.0 0.391 0.0 NA
HOH
 5.744
2.896
 O
N
 NA
O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 ARG B:205 B:357 88.0 0.391 T -73.4 -8.7 88.0 0.391 0.0 NA
HOH
 6.044
2.908
 O
O
 NA
O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ARG A:357 A:357 177.0 0.787 T -62.0 -22.7 177.0 0.787 0.0 CA
HOH
 6.402
3.016
 O
NH1
 CA
O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ARG A:357 A:357 182.0 0.809 T -68.6 -12.8 182.0 0.809 0.0 CA
 5.930
 O
 CA
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ARG A:357 A:357 175.0 0.778 T -68.7 -19.5 175.0 0.778 0.0 CA
HOH
 6.427
2.742
 O
NH1
 CA
O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ARG A:357 A:357 180.0 0.8 T -64.3 -6.2 180.0 0.8 0.0 CA
HOH
 6.369
2.676
 O
O
 CA
O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 ARG B:205 B:357 179.0 0.796 T -72.2 -19.2 179.0 0.796 0.0 HOH
 2.833
 O
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ARG B:205 B:357 173.0 0.769 T -67.5 -17.4 173.0 0.769 0.0 HOH
 2.898
 NH1
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ARG B:205 B:357 175.0 0.778 T -69.8 -18.9 175.0 0.778 0.0 HOH
 2.762
 O
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ARG B:205 B:357 171.0 0.76 T -69.0 -16.5 171.0 0.76 0.0 HOH
 2.927
 O
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ARG B:205 B:357 175.0 0.778 T -67.6 -18.7 175.0 0.778 0.0 HOH
 2.875
 NH2
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ARG B:205 B:357 168.0 0.747 T -71.4 -15.2 168.0 0.747 0.0 HOH
 2.827
 NH2
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ARG B:205 B:357 177.0 0.787 T -65.3 -17.2 177.0 0.787 0.0 HOH
 2.649
 O
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ARG B:205 B:357 216.0 0.96 T -62.0 -24.8 216.0 0.96 0.0 HOH
 2.852
 NH2
 O
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ARG A:205 A:357 172.0 0.764 T -70.9 -16.9 172.0 0.764 0.0 CA
HOH
 5.986
2.982
 O
N
 CA
O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ARG A:205 A:357 162.0 0.72 T -65.5 -17.7 162.0 0.72 0.0 CA
HOH
 6.147
3.012
 O
N
 CA
O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ARG A:205 A:357 171.0 0.76 T -61.7 -21.7 171.0 0.76 0.0 HOH
 5.793
 O
 O
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ARG A:205 A:357 161.0 0.716 T -63.8 -24.4 161.0 0.716 0.0 CA
HOH
 6.101
3.176
 O
N
 CA
O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ARG A:205 A:357 157.0 0.698 T -59.2 -28.4 157.0 0.698 0.0 HOH
 5.958
 O
 O
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 ARG A:205 A:357 215.0 0.956 T -62.9 -17.0 215.0 0.956 0.0 CA
HOH
 6.646
3.230
 O
N
 CA
O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 ARG B:205 B:357 183.0 0.813 T -61.5 -19.3 183.0 0.813 0.0 PG4
HOH
 7.395
2.806
 O
NH1
 O5
O
ARG D:205 E:357 183.0 0.813 T -61.4 -19.2 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 ARG A:357 A:357 85.0 0.378 T -62.6 -6.8