Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55523106 . G A CCDS603.1:NM_174936.3:c.1099Gac>Aac_NP_777596.2:p.367D>N Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
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label_seq_id: 
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auth_asym_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 ASP A:367 NA:NA DO NA DO DO DO NA NA NA
ASP B:367 A:367 89.0 0.593 S 57.1 56.2 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ASP A:367 A:367 104.0 0.693 S 53.2 67.4 87.0 0.58 0.113 B:None:0.113
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 ASP A:367 A:367 114.0 0.76 S 52.3 52.6 63.0 0.42 0.34 D:None:0.34
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ASP A:367 A:367 108.0 0.72 S 50.6 62.2 89.0 0.593 0.127 B:None:0.127
 HOH
 8.439
 H
 O
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASP A:337 NA:NA DO NA DO DO DO NA NA NA
ASP B:337 B:367 89.0 0.593 S 53.4 52.8 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASP A:337 NA:NA DO NA DO DO DO NA NA NA
ASP B:337 B:367 92.0 0.613 S 58.2 57.0 92.0 0.613 0.0 HOH
 2.722
 O
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASP A:337 NA:NA DO NA DO DO DO NA NA NA
ASP B:337 B:367 89.0 0.593 S 56.0 53.9 89.0 0.593 0.0 HOH
 2.697
 OD1
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASP A:337 NA:NA DO NA DO DO DO NA NA NA
ASP B:337 B:367 95.0 0.633 S 55.9 56.3 95.0 0.633 0.0
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASP A:337 NA:NA DO NA DO DO DO NA NA NA
ASP B:337 B:367 98.0 0.653 S 58.7 53.7 98.0 0.653 0.0 HOH
 2.882
 O
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASP A:337 NA:NA DO NA DO DO DO NA NA NA
ASP B:337 B:367 100.0 0.667 S 58.7 44.0 100.0 0.667 0.0 HOH
 4.283
 CB
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 ASP B:215 B:367 92.0 0.613 S 52.1 56.0 92.0 0.613 0.0 HOH
 2.624
 OD2
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ASP B:215 A:367 98.0 0.653 S 56.3 51.8 78.0 0.52 0.133 C:Q59FQ1:0.133
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ASP B:215 A:367 97.0 0.647 S 56.2 51.9 77.0 0.513 0.134 C:Q59FQ1:0.133
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 ASP B:215 A:367 82.0 0.547 S 59.1 53.5 62.0 0.413 0.134 C:P01130:0.133
 HOH
 2.804
 O
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ASP B:215 A:367 93.0 0.62 S 40.2 60.7 90.0 0.6 0.02 C:P01130:0.02
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ASP B:215 A:367 97.0 0.647 S 45.9 56.2 96.0 0.64 0.007 C:P01130:0.007
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 ASP A:215 A:367 92.0 0.613 S 60.6 52.2 88.0 0.587 0.026 C:None:0.027
 HOH
 2.913
 O
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 ASP A:215 A:367 90.0 0.6 S 52.3 56.5 90.0 0.6 0.0
ASP B:215 B:367 81.0 0.54 S 52.1 55.7 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 ASP B:215 B:367 96.0 0.64 S 45.3 58.1 96.0 0.64 0.0 HOH
 5.291
 OD2
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 ASP B:215 B:367 102.0 0.68 S 44.5 52.6 41.0 0.273 0.407 C:None:0.407
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 ASP B:215 B:367 89.0 0.593 S 56.6 51.8 89.0 0.593 0.0 HOH
 2.447
 OD1
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 ASP B:215 B:367 88.0 0.587 S 64.4 53.0 59.0 0.393 0.194 C:None:0.193
 HOH
 8.026
 N
 O
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 ASP B:215 B:367 88.0 0.587 S 59.2 58.5 69.0 0.46 0.127 C:None:0.127
 HOH
 2.660
 O
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 ASP B:215 B:367 90.0 0.6 S 56.4 52.0 65.0 0.433 0.167 C:P01130:0.167
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 ASP B:215 B:367 90.0 0.6 S 58.8 52.3 78.0 0.52 0.08 D:None:0.08
 HOH
 2.540
 OD1
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 ASP B:215 B:367 89.0 0.593 S 58.2 52.8 77.0 0.513 0.08 C:None:0.08
 NA
HOH
 9.030
2.564
 O
OD1
 NA
O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASP A:367 A:367 121.0 0.807 S 57.1 54.4 96.0 0.64 0.167 B:None:0.167
 HOH
 2.719
 OD2
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASP A:367 A:367 124.0 0.827 S 55.7 59.1 98.0 0.653 0.174 B:None:0.173
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASP A:367 A:367 117.0 0.78 S 62.0 51.4 93.0 0.62 0.16 C:None:0.16
 HOH
 2.828
 O
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASP A:367 A:367 117.0 0.78 S 58.0 59.1 92.0 0.613 0.167 B:None:0.167
 HOH
 2.797
 OD2
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 ASP B:215 B:367 87.0 0.58 S 56.8 54.3 73.0 0.487 0.093 C:None:0.093
 HOH
 2.800
 O
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASP B:215 B:367 88.0 0.587 S 52.4 53.9 42.0 0.28 0.307 C:None:0.307
 HOH
 2.602
 OD2
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASP B:215 B:367 89.0 0.593 S 54.2 52.7 43.0 0.287 0.306 C:None:0.307
 HOH
 2.690
 OD1
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASP B:215 B:367 87.0 0.58 S 52.4 53.7 39.0 0.26 0.32 C:None:0.32
 HOH
 2.617
 OD1
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASP B:215 B:367 88.0 0.587 S 49.3 51.5 66.0 0.44 0.147 C:None:0.147
 HOH
 2.697
 OD1
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASP B:215 B:367 87.0 0.58 S 52.4 46.4 58.0 0.387 0.193 C:None:0.193
 HOH
 2.555
 OD1
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ASP B:215 B:367 89.0 0.593 S 48.5 55.7 57.0 0.38 0.213 C:None:0.213
 HOH
 2.846
 O
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ASP B:215 B:367 100.0 0.667 S 53.3 49.7 74.0 0.493 0.174 C:None:0.173
 HOH
 2.575
 O
 O
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ASP A:215 A:367 90.0 0.6 S 50.1 59.3 90.0 0.6 0.0 HOH
 2.797
 O
 O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ASP A:215 A:367 87.0 0.58 S 51.6 57.8 87.0 0.58 0.0 HOH
 2.686
 O
 O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ASP A:215 A:367 86.0 0.573 S 51.7 51.9 85.0 0.567 0.006 B:P01130:0.007
 HOH
 3.108
 OD1
 O
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ASP A:215 A:367 89.0 0.593 S 50.4 54.6 84.0 0.56 0.033 B:P01130:0.033
 HOH
 2.564
 OD1
 O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ASP A:215 A:367 93.0 0.62 S 41.1 62.3 90.0 0.6 0.02 B:P01130:0.02
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 ASP A:215 A:367 81.0 0.54 S 45.4 61.3 77.0 0.513 0.027 D:None:0.027
 HOH
 7.694
 O
 O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 ASP B:215 B:367 94.0 0.627 S 53.7 53.2 62.0 0.413 0.214 E:None:0.213
 HOH
 2.638
 O
 O
ASP D:215 E:367 96.0 0.64 S 54.1 52.3 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 ASP A:367 A:367 18.0 0.12 S 61.1 76.8