Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55523127 . G A CCDS603.1:NM_174936.3:c.1120Gac>Aac_NP_777596.2:p.374D>N Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 ASP A:374 NA:NA DO NA DO DO DO NA NA NA
ASP B:374 A:374 119.0 0.793 T -59.1 -44.9 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ASP A:374 A:374 136.0 0.907 T -56.4 -38.0 136.0 0.907 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 ASP A:374 A:374 133.0 0.887 T -61.6 -35.5 133.0 0.887 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ASP A:374 A:374 138.0 0.92 T -51.7 -41.5 138.0 0.92 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASP A:344 NA:NA DO NA DO DO DO NA NA NA
ASP B:344 B:374 116.0 0.773 T -59.0 -38.5 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASP A:344 NA:NA DO NA DO DO DO NA NA NA
ASP B:344 B:374 120.0 0.8 T -47.9 -50.2 120.0 0.8 0.0 HOH
 8.560
 OD1
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASP A:344 NA:NA DO NA DO DO DO NA NA NA
ASP B:344 B:374 116.0 0.773 T -63.9 -33.5 116.0 0.773 0.0 HOH
 2.826
 OD2
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASP A:344 NA:NA DO NA DO DO DO NA NA NA
ASP B:344 B:374 124.0 0.827 T -72.3 -42.2 83.0 0.553 0.274 D:None:0.233
C:None:0.033
 HOH
 6.786
 O
 O
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASP A:344 NA:NA DO NA DO DO DO NA NA NA
ASP B:344 B:374 115.0 0.767 T -75.6 -39.8 81.0 0.54 0.227 D:None:0.193
C:None:0.033
 HOH
 8.191
 O
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASP A:344 NA:NA DO NA DO DO DO NA NA NA
ASP B:344 B:374 120.0 0.8 T -58.9 -42.6 120.0 0.8 0.0 HOH
 9.930
 OD1
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 ASP B:222 B:374 114.0 0.76 T -65.5 -34.9 114.0 0.76 0.0 HOH
 2.747
 O
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ASP B:222 A:374 138.0 0.92 S -66.0 -45.3 102.0 0.68 0.24 C:Q59FQ1:0.24
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ASP B:222 A:374 137.0 0.913 S -65.9 -45.3 100.0 0.667 0.246 C:Q59FQ1:0.247
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 ASP B:222 A:374 120.0 0.8 T -70.3 -29.5 68.0 0.453 0.347 C:P01130:0.347
 HOH
 4.491
 OD1
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ASP B:222 A:374 110.0 0.733 T -65.1 -37.7 53.0 0.353 0.38 C:P01130:0.38
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ASP B:222 A:374 115.0 0.767 T -70.2 -38.3 70.0 0.467 0.3 C:P01130:0.3
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 ASP A:222 A:374 101.0 0.673 S -60.7 -33.1 57.0 0.38 0.293 C:None:0.293
 HOH
 7.858
 OD1
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 ASP A:222 A:374 115.0 0.767 T -66.4 -37.6 115.0 0.767 0.0
ASP B:222 B:374 112.0 0.747 T -66.8 -38.1 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 ASP B:222 B:374 91.0 0.607 T -64.3 -41.1 91.0 0.607 0.0 HOH
 4.791
 O
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 ASP B:222 B:374 124.0 0.827 T -55.6 -34.2 106.0 0.707 0.12 C:None:0.12
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 ASP B:222 B:374 108.0 0.72 T -60.3 -44.3 108.0 0.72 0.0 HOH
 3.236
 OD2
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 ASP B:222 B:374 117.0 0.78 T -76.0 -44.2 117.0 0.78 0.0
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 ASP B:222 B:374 120.0 0.8 T -64.8 -34.0 120.0 0.8 0.0 HOH
 4.002
 OD1
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 TYR B:222 B:374 175.0 0.761 T -60.2 -44.4 78.0 0.339 0.422 C:P01130:0.422
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 ASP B:222 B:374 94.0 0.627 T -51.4 -45.4 65.0 0.433 0.194 D:None:0.193
 HOH
 2.584
 OD2
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 ASP B:222 B:374 95.0 0.633 T -52.2 -43.1 66.0 0.44 0.193 C:None:0.193
 HOH
 2.359
 OD2
 O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASP A:374 A:374 129.0 0.86 T -70.1 -30.6 106.0 0.707 0.153 B:None:0.153
 HOH
 5.460
 N
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASP A:374 A:374 107.0 0.713 T -57.7 -51.0 84.0 0.56 0.153 C:None:0.153
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASP A:374 A:374 113.0 0.753 T -61.2 -40.1 89.0 0.593 0.16 B:None:0.16
 HOH
 2.520
 OD2
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASP A:374 A:374 117.0 0.78 S -61.9 -43.5 92.0 0.613 0.167 C:None:0.167
 HOH
 5.767
 N
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 ASP B:222 B:374 107.0 0.713 T -62.4 -32.3 83.0 0.553 0.16 C:None:0.16
 HOH
 2.516
 OD1
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASP B:222 B:374 106.0 0.707 T -66.9 -29.3 81.0 0.54 0.167 C:None:0.167
 HOH
 2.656
 OD1
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASP B:222 B:374 121.0 0.807 T -69.4 -28.2 95.0 0.633 0.174 C:None:0.173
 HOH
 2.618
 OD1
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASP B:222 B:374 104.0 0.693 T -71.1 -23.6 80.0 0.533 0.16 C:None:0.16
 HOH
 2.702
 OD1
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASP B:222 B:374 119.0 0.793 T -67.9 -27.6 99.0 0.66 0.133 C:None:0.133
 HOH
 2.634
 OD2
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASP B:222 B:374 117.0 0.78 T -65.4 -33.9 98.0 0.653 0.127 C:None:0.127
 HOH
 2.525
 OD2
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ASP B:222 B:374 123.0 0.82 T -74.1 -19.6 105.0 0.7 0.12 C:None:0.12
 89N
HOH
 5.885
2.910
 CB
OD2
 C2
O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ASP B:222 B:374 103.0 0.687 T -61.6 -30.9 81.0 0.54 0.147 C:None:0.147
 89N
HOH
 4.936
2.595
 OD2
OD1
 C2
O
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ASP A:222 A:374 106.0 0.707 T -66.0 -33.7 78.0 0.52 0.187 B:P01130:0.187
 HOH
 2.674
 OD1
 O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ASP A:222 A:374 110.0 0.733 T -66.2 -31.3 63.0 0.42 0.313 B:P01130:0.313
 HOH
 3.343
 O
 O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ALA A:222 A:374 72.0 0.626 T -72.8 -44.6 56.0 0.487 0.139 B:P01130:0.139
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 HIS A:222 A:374 149.0 0.764 T -63.5 -39.2 75.0 0.385 0.379 B:P01130:0.379
 HOH
 3.123
 CD2
 O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 TYR A:222 A:374 188.0 0.817 T -73.2 -38.0 100.0 0.435 0.382 B:P01130:0.383
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 ASP A:222 A:374 111.0 0.74 S -65.0 -39.6 48.0 0.32 0.42 D:None:0.42
 HOH
 2.689
 O
 O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 ASP B:222 B:374 138.0 0.92 T -62.4 -38.4 95.0 0.633 0.287 E:None:0.287
 HOH
 2.718
 OD1
 O
ASP D:222 E:374 139.0 0.927 T -63.1 -37.4 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 ASP A:374 A:374 129.0 0.86 T -73.3 -36.7