Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55523141 . C A CCDS603.1:NM_174936.3:c.1134tgC>tgA_NP_777596.2:p.378C>* Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 CYS A:378 NA:NA DO NA DO DO DO NA NA NA
CYS B:378 A:378 38.0 0.281 -81.8 150.9 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 CYS A:378 A:378 38.0 0.281 -88.6 153.3 38.0 0.281 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 CYS A:378 A:378 35.0 0.259 -104.1 151.0 35.0 0.259 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 CYS A:378 A:378 38.0 0.281 -91.2 151.5 38.0 0.281 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 CYS A:348 NA:NA DO NA DO DO DO NA NA NA
CYS B:348 B:378 43.0 0.319 -77.7 153.9 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 CYS A:348 NA:NA DO NA DO DO DO NA NA NA
CYS B:348 B:378 45.0 0.333 -75.8 151.1 45.0 0.333 0.0 HOH
 6.875
 O
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 CYS A:348 NA:NA DO NA DO DO DO NA NA NA
CYS B:348 B:378 45.0 0.333 -76.0 153.2 45.0 0.333 0.0 HOH
 5.853
 CB
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 CYS A:348 NA:NA DO NA DO DO DO NA NA NA
CYS B:348 B:378 41.0 0.304 -77.9 147.6 8.0 0.059 0.245 D:None:0.244
 HOH
 9.256
 SG
 O
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 CYS A:348 NA:NA DO NA DO DO DO NA NA NA
CYS B:348 B:378 43.0 0.319 -74.6 149.6 9.0 0.067 0.252 D:None:0.252
 HOH
 5.339
 N
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 CYS A:348 NA:NA DO NA DO DO DO NA NA NA
CYS B:348 B:378 48.0 0.356 -59.4 154.9 48.0 0.356 0.0
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 CYS B:226 B:378 46.0 0.341 -76.8 159.1 46.0 0.341 0.0 HOH
 6.772
 N
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 CYS B:226 A:378 31.0 0.23 -100.9 146.3 1.0 0.007 0.223 C:Q59FQ1:0.222
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 CYS B:226 A:378 31.0 0.23 -100.9 146.2 1.0 0.007 0.223 C:Q59FQ1:0.222
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 CYS B:226 A:378 37.0 0.274 -100.9 148.1 0.0 0.0 0.274 C:P01130:0.274
 HOH
 6.821
 O
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 CYS B:226 A:378 39.0 0.289 E -95.4 149.2 0.0 0.0 0.289 C:P01130:0.289
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 CYS B:226 A:378 36.0 0.267 -91.6 147.8 0.0 0.0 0.267 C:P01130:0.267
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 CYS A:226 A:378 33.0 0.244 -98.0 147.4 1.0 0.007 0.237 C:None:0.237
 HOH
 3.788
 CA
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 CYS A:226 A:378 40.0 0.296 -84.8 145.2 40.0 0.296 0.0
CYS B:226 B:378 42.0 0.311 -85.8 142.7 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 CYS B:226 B:378 37.0 0.274 -83.1 153.1 37.0 0.274 0.0 HOH
 4.813
 N
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 CYS B:226 B:378 38.0 0.281 E -92.2 150.3 0.0 0.0 0.281 D:Q7Z3Y4:0.052
C:None:0.281
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 CYS B:226 B:378 45.0 0.333 -83.3 158.0 45.0 0.333 0.0 HOH
 3.695
 CB
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 CYS B:226 B:378 44.0 0.326 -85.4 161.0 44.0 0.326 0.0
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 CYS B:226 B:378 46.0 0.341 -96.0 149.7 46.0 0.341 0.0 HOH
 6.758
 O
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 CYS B:226 B:378 32.0 0.237 -83.4 158.1 0.0 0.0 0.237 C:P01130:0.237
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 CYS B:226 B:378 41.0 0.304 -81.6 147.4 41.0 0.304 0.0 HOH
 3.657
 SG
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 CYS B:226 B:378 42.0 0.311 -91.4 152.9 42.0 0.311 0.0 NA
HOH
 8.726
3.592
 O
SG
 NA
O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 CYS A:378 A:378 38.0 0.281 -77.9 138.0 5.0 0.037 0.244 B:None:0.244
 HOH
 6.544
 O
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 CYS A:378 A:378 36.0 0.267 -68.0 140.8 5.0 0.037 0.23 C:None:0.23
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 CYS A:378 A:378 39.0 0.289 -79.6 145.0 5.0 0.037 0.252 B:None:0.252
 HOH
 6.190
 N
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 CYS A:378 A:378 35.0 0.259 -76.9 149.4 5.0 0.037 0.222 C:None:0.222
 HOH
 6.111
 N
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 CYS B:226 B:378 39.0 0.289 E -84.5 151.7 5.0 0.037 0.252 C:None:0.252
 HOH
 5.161
 N
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 CYS B:226 B:378 42.0 0.311 -79.5 150.8 3.0 0.022 0.289 C:None:0.289
 HOH
 5.175
 N
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 CYS B:226 B:378 41.0 0.304 -79.9 148.7 2.0 0.015 0.289 C:None:0.289
 HOH
 5.529
 N
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 CYS B:226 B:378 42.0 0.311 -75.0 151.2 2.0 0.015 0.296 C:None:0.296
 HOH
 5.322
 N
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 CYS B:226 B:378 41.0 0.304 -72.7 148.5 0.0 0.0 0.304 C:None:0.304
 HOH
 3.958
 SG
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 CYS B:226 B:378 42.0 0.311 -71.2 148.5 0.0 0.0 0.311 C:None:0.311
 HOH
 4.370
 SG
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 CYS B:226 B:378 41.0 0.304 -71.6 153.1 5.0 0.037 0.267 C:None:0.267
 89N
HOH
 3.346
6.469
 SG
N
 C5
O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 CYS B:226 B:378 38.0 0.281 -72.4 149.1 5.0 0.037 0.244 C:None:0.244
 89N
HOH
 3.635
4.412
 SG
SG
 C5
O
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 CYS A:226 A:378 40.0 0.296 -93.2 147.0 0.0 0.0 0.296 B:P01130:0.296
 HOH
 5.333
 N
 O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 CYS A:226 A:378 38.0 0.281 -97.5 147.2 0.0 0.0 0.281 B:P01130:0.281
 HOH
 6.298
 SG
 O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 CYS A:226 A:378 34.0 0.252 E -99.9 144.8 0.0 0.0 0.252 B:P01130:0.252
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 CYS A:226 A:378 28.0 0.207 -94.9 145.4 0.0 0.0 0.207 B:P01130:0.207
 HOH
 5.266
 N
 O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 CYS A:226 A:378 30.0 0.222 -88.7 150.3 0.0 0.0 0.222 B:P01130:0.222
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 CYS A:226 A:378 40.0 0.296 -96.6 147.4 0.0 0.0 0.296 D:None:0.296
 HOH
 6.530
 SG
 O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 CYS B:226 B:378 43.0 0.319 -77.6 152.8 43.0 0.319 0.0 EDO
HOH
 7.354
3.584
 C
CA
 O2
O
CYS D:226 E:378 43.0 0.319 -76.8 152.7 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 CYS A:378 A:378 37.0 0.274 -87.1 143.1