Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55523178 . C A CCDS603.1:NM_174936.3:c.1171Cac>Aac_NP_777596.2:p.391H>N Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 HIS A:391 NA:NA DO NA DO DO DO NA NA NA
HIS B:391 A:391 0.0 0.0 H -59.4 -47.1 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 HIS A:391 A:391 31.0 0.159 H -62.8 -46.3 0.0 0.0 0.159 B:None:0.159
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 HIS A:391 A:391 29.0 0.149 H -58.7 -47.7 0.0 0.0 0.149 D:None:0.149
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 HIS A:391 A:391 30.0 0.154 H -62.6 -45.3 0.0 0.0 0.154 B:None:0.154
 HOH
 9.897
 HE1
 O
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:361 NA:NA DO NA DO DO DO NA NA NA
HIS B:361 B:391 0.0 0.0 H -63.1 -44.5 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:361 NA:NA DO NA DO DO DO NA NA NA
HIS B:361 B:391 0.0 0.0 H -62.5 -45.2 0.0 0.0 0.0 HOH
 4.849
 NE2
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:361 NA:NA DO NA DO DO DO NA NA NA
HIS B:361 B:391 0.0 0.0 H -63.2 -45.4 0.0 0.0 0.0 HOH
 5.039
 NE2
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:361 NA:NA DO NA DO DO DO NA NA NA
HIS B:361 B:391 4.0 0.021 H -64.9 -44.1 4.0 0.021 0.0
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:361 NA:NA DO NA DO DO DO NA NA NA
HIS B:361 B:391 5.0 0.026 H -67.3 -44.6 5.0 0.026 0.0 HOH
 4.091
 CE1
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:361 NA:NA DO NA DO DO DO NA NA NA
HIS B:361 B:391 0.0 0.0 H -68.7 -48.1 0.0 0.0 0.0 HOH
 8.745
 NE2
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 HIS B:239 B:391 0.0 0.0 H -65.5 -43.7 0.0 0.0 0.0 HOH
 5.034
 NE2
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 HIS B:239 A:391 0.0 0.0 H -70.3 -46.4 0.0 0.0 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 HIS B:239 A:391 0.0 0.0 H -70.3 -46.5 0.0 0.0 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 HIS B:239 A:391 0.0 0.0 H -56.7 -53.8 0.0 0.0 0.0 HOH
 5.307
 NE2
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 HIS B:239 A:391 0.0 0.0 H -60.1 -49.8 0.0 0.0 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 HIS B:239 A:391 0.0 0.0 H -58.0 -50.9 0.0 0.0 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 HIS A:239 A:391 0.0 0.0 H -53.3 -51.2 0.0 0.0 0.0 HOH
 7.001
 NE2
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 HIS A:239 A:391 0.0 0.0 H -61.1 -45.4 0.0 0.0 0.0
HIS B:239 B:391 0.0 0.0 H -61.2 -45.9 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 HIS B:239 B:391 0.0 0.0 H -62.7 -44.6 0.0 0.0 0.0 HOH
 8.048
 CD2
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 HIS B:239 B:391 42.0 0.215 H -61.3 -51.0 23.0 0.118 0.097 C:None:0.097
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 HIS B:239 B:391 0.0 0.0 H -60.9 -42.5 0.0 0.0 0.0 HOH
 4.946
 NE2
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 HIS B:239 B:391 0.0 0.0 H -61.0 -38.8 0.0 0.0 0.0 HOH
 7.817
 O
 O
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 HIS B:239 B:391 0.0 0.0 H -61.1 -43.2 0.0 0.0 0.0 HOH
 4.848
 NE2
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 HIS B:239 B:391 0.0 0.0 H -60.9 -42.4 0.0 0.0 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 HIS B:239 B:391 0.0 0.0 H -63.6 -46.4 0.0 0.0 0.0 HOH
 5.199
 NE2
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 HIS B:239 B:391 0.0 0.0 H -64.0 -47.0 0.0 0.0 0.0 NA
HOH
 7.067
2.934
 CE1
CB
 NA
O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 HIS A:391 A:391 31.0 0.159 H -62.3 -41.9 0.0 0.0 0.159 B:None:0.159
 HOH
 5.138
 NE2
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 HIS A:391 A:391 30.0 0.154 H -70.7 -47.3 0.0 0.0 0.154 B:None:0.154
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 HIS A:391 A:391 31.0 0.159 H -56.2 -43.5 0.0 0.0 0.159 C:None:0.159
 HOH
 5.274
 NE2
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 HIS A:391 A:391 33.0 0.169 H -66.0 -49.8 0.0 0.0 0.169 B:None:0.169
 HOH
 6.881
 CE1
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 HIS B:239 B:391 0.0 0.0 H -61.2 -48.5 0.0 0.0 0.0 HOH
 5.256
 CE1
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 HIS B:239 B:391 0.0 0.0 H -62.1 -44.5 0.0 0.0 0.0 HOH
 5.173
 NE2
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 HIS B:239 B:391 0.0 0.0 H -62.6 -44.1 0.0 0.0 0.0 HOH
 5.241
 NE2
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 HIS B:239 B:391 0.0 0.0 H -60.8 -43.6 0.0 0.0 0.0 HOH
 5.264
 NE2
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 HIS B:239 B:391 0.0 0.0 H -64.4 -43.6 0.0 0.0 0.0 HOH
 5.180
 NE2
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 HIS B:239 B:391 0.0 0.0 H -64.4 -46.2 0.0 0.0 0.0 HOH
 4.998
 NE2
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 HIS B:239 B:391 0.0 0.0 H -64.7 -40.8 0.0 0.0 0.0 HOH
 5.399
 NE2
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 HIS B:239 B:391 53.0 0.272 H -59.0 -47.3 53.0 0.272 0.0 HOH
 2.795
 ND1
 O
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 HIS A:239 A:391 0.0 0.0 H -67.9 -46.7 0.0 0.0 0.0 HOH
 5.144
 NE2
 O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 HIS A:239 A:391 0.0 0.0 H -70.4 -48.0 0.0 0.0 0.0 HOH
 5.258
 NE2
 O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 HIS A:239 A:391 0.0 0.0 H -69.1 -45.2 0.0 0.0 0.0 HOH
 9.723
 NE2
 O
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 HIS A:239 A:391 0.0 0.0 H -64.8 -45.1 0.0 0.0 0.0 HOH
 5.104
 NE2
 O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 HIS A:239 A:391 0.0 0.0 H -52.1 -51.8 0.0 0.0 0.0
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 HIS A:239 A:391 27.0 0.138 H -64.7 -50.5 27.0 0.138 0.0 HOH
 2.511
 ND1
 O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 HIS B:239 B:391 0.0 0.0 H -65.7 -47.2 0.0 0.0 0.0 HOH
 6.816
 NE2
 O
HIS D:239 E:391 1.0 0.005 H -66.1 -46.6 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 HIS A:391 A:391 11.0 0.056 H -61.4 -47.1