Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55523181 . G A CCDS603.1:NM_174936.3:c.1174Gtg>Atg_NP_777596.2:p.392V>M Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 VAL A:392 NA:NA DO NA DO DO DO NA NA NA
VAL B:392 A:392 0.0 0.0 H -67.2 -36.7 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 VAL A:392 A:392 0.0 0.0 H -68.0 -36.6 0.0 0.0 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 VAL A:392 A:392 0.0 0.0 H -66.2 -40.3 0.0 0.0 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 VAL A:392 A:392 0.0 0.0 H -67.2 -36.7 0.0 0.0 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:362 NA:NA DO NA DO DO DO NA NA NA
VAL B:362 B:392 0.0 0.0 H -68.3 -34.4 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:362 NA:NA DO NA DO DO DO NA NA NA
VAL B:362 B:392 0.0 0.0 H -66.9 -35.1 0.0 0.0 0.0 HOH
 6.488
 CG2
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:362 NA:NA DO NA DO DO DO NA NA NA
VAL B:362 B:392 0.0 0.0 H -67.8 -34.9 0.0 0.0 0.0 HOH
 6.354
 CG2
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:362 NA:NA DO NA DO DO DO NA NA NA
VAL B:362 B:392 0.0 0.0 H -70.9 -35.4 0.0 0.0 0.0
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:362 NA:NA DO NA DO DO DO NA NA NA
VAL B:362 B:392 0.0 0.0 H -71.1 -35.7 0.0 0.0 0.0 HOH
 9.385
 N
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:362 NA:NA DO NA DO DO DO NA NA NA
VAL B:362 B:392 0.0 0.0 H -64.3 -37.4 0.0 0.0 0.0
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 VAL B:240 B:392 0.0 0.0 H -71.8 -35.6 0.0 0.0 0.0 HOH
 9.524
 CG1
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 VAL B:240 A:392 0.0 0.0 H -65.9 -37.8 0.0 0.0 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 VAL B:240 A:392 0.0 0.0 H -66.0 -37.8 0.0 0.0 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 VAL B:240 A:392 0.0 0.0 H -62.6 -30.9 0.0 0.0 0.0 HOH
 6.602
 CG2
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 VAL B:240 A:392 0.0 0.0 H -66.9 -35.1 0.0 0.0 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 VAL B:240 A:392 0.0 0.0 H -68.8 -33.0 0.0 0.0 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 VAL A:240 A:392 2.0 0.013 H -71.1 -30.6 2.0 0.013 0.0 HOH
 9.730
 CG2
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 VAL A:240 A:392 0.0 0.0 H -69.3 -35.0 0.0 0.0 0.0
VAL B:240 B:392 0.0 0.0 H -68.9 -34.6 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 VAL B:240 B:392 0.0 0.0 H -66.1 -38.3 0.0 0.0 0.0
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 VAL B:240 B:392 0.0 0.0 H -64.6 -40.1 0.0 0.0 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 VAL B:240 B:392 0.0 0.0 H -73.4 -36.7 0.0 0.0 0.0 HOH
 6.412
 CG2
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 VAL B:240 B:392 0.0 0.0 H -76.3 -37.9 0.0 0.0 0.0 HOH
 6.515
 CG2
 O
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 VAL B:240 B:392 0.0 0.0 H -68.8 -38.4 0.0 0.0 0.0 HOH
 6.335
 CG2
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 VAL B:240 B:392 0.0 0.0 H -73.5 -36.6 0.0 0.0 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 VAL B:240 B:392 0.0 0.0 H -68.5 -28.2 0.0 0.0 0.0 HOH
 6.846
 CG2
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 VAL B:240 B:392 0.0 0.0 H -68.9 -28.6 0.0 0.0 0.0 HOH
 3.884
 N
 O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 VAL A:392 A:392 0.0 0.0 H -71.2 -36.9 0.0 0.0 0.0 HOH
 6.540
 CG2
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 VAL A:392 A:392 0.0 0.0 H -63.1 -37.7 0.0 0.0 0.0
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 VAL A:392 A:392 0.0 0.0 H -73.9 -35.2 0.0 0.0 0.0 HOH
 6.447
 CG2
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 VAL A:392 A:392 0.0 0.0 H -63.6 -39.8 0.0 0.0 0.0 HOH
 6.549
 CG2
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 VAL B:240 B:392 0.0 0.0 H -65.9 -36.1 0.0 0.0 0.0 HOH
 6.646
 CG2
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 VAL B:240 B:392 0.0 0.0 H -67.8 -36.4 0.0 0.0 0.0 HOH
 6.647
 CG2
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 VAL B:240 B:392 0.0 0.0 H -68.2 -34.5 0.0 0.0 0.0 HOH
 6.637
 CG2
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 VAL B:240 B:392 0.0 0.0 H -69.8 -35.2 0.0 0.0 0.0 HOH
 6.655
 CG2
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 VAL B:240 B:392 0.0 0.0 H -67.6 -35.3 0.0 0.0 0.0 HOH
 6.687
 CG2
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 VAL B:240 B:392 0.0 0.0 H -67.7 -32.5 0.0 0.0 0.0 HOH
 6.482
 CG2
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 VAL B:240 B:392 0.0 0.0 H -72.7 -37.2 0.0 0.0 0.0 HOH
 6.653
 CG2
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 VAL B:240 B:392 3.0 0.019 H -65.5 -37.0 3.0 0.019 0.0 HOH
 6.359
 N
 O
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 VAL A:240 A:392 0.0 0.0 H -68.1 -40.8 0.0 0.0 0.0 HOH
 6.341
 CG2
 O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 VAL A:240 A:392 0.0 0.0 H -65.1 -38.0 0.0 0.0 0.0 HOH
 6.580
 CG2
 O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 VAL A:240 A:392 0.0 0.0 H -70.9 -33.7 0.0 0.0 0.0
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 VAL A:240 A:392 0.0 0.0 H -67.6 -38.2 0.0 0.0 0.0 HOH
 6.732
 CG2
 O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 VAL A:240 A:392 0.0 0.0 H -61.5 -43.3 0.0 0.0 0.0
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 VAL A:240 A:392 3.0 0.019 H -60.1 -38.3 3.0 0.019 0.0 HOH
 6.641
 N
 O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 VAL B:240 B:392 0.0 0.0 H -66.7 -37.7 0.0 0.0 0.0
VAL D:240 E:392 0.0 0.0 H -67.5 -37.8 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 VAL A:392 A:392 0.0 0.0 H -67.6 -35.6