Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55523763 . G A CCDS603.1:NM_174936.3:c.1235aGg>aAg_NP_777596.2:p.412R>K Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 ARG A:412 NA:NA DO NA DO DO DO NA NA NA
ARG B:412 A:412 9.0 0.04 H -60.4 -42.1 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ARG A:412 A:412 15.0 0.067 H -57.4 -46.4 15.0 0.067 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 ARG A:412 A:412 11.0 0.049 H -59.9 -41.8 11.0 0.049 0.0 NA
HOH
 5.637
8.471
 NH1
O
 NA
O
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ARG A:412 A:412 15.0 0.067 H -63.4 -43.5 15.0 0.067 0.0 HOH
 6.381
 HH11
 O
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:382 NA:NA DO NA DO DO DO NA NA NA
ARG B:382 B:412 8.0 0.036 H -59.8 -44.4 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:382 NA:NA DO NA DO DO DO NA NA NA
ARG B:382 B:412 8.0 0.036 H -66.4 -37.8 8.0 0.036 0.0 PV7
HOH
 3.771
3.036
 NE
NH1
 C10
O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:382 NA:NA DO NA DO DO DO NA NA NA
ARG B:382 B:412 10.0 0.044 H -58.7 -43.9 10.0 0.044 0.0 PUV
HOH
 3.395
2.759
 NH1
NE
 C9
O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:382 NA:NA DO NA DO DO DO NA NA NA
ARG B:382 B:412 6.0 0.027 H -63.7 -45.2 6.0 0.027 0.0 PVM
HOH
 3.770
4.556
 NE
NH1
 C17
O
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:382 NA:NA DO NA DO DO DO NA NA NA
ARG B:382 B:412 9.0 0.04 H -65.6 -45.2 9.0 0.04 0.0 PVJ
HOH
 3.715
6.493
 NE
NH1
 C17
O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:382 NA:NA DO NA DO DO DO NA NA NA
ARG B:382 B:412 13.0 0.058 H -58.1 -44.1 13.0 0.058 0.0 PVV
HOH
 3.923
8.715
 NE
O
 C9
O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 ARG B:260 B:412 13.0 0.058 H -68.4 -37.0 13.0 0.058 0.0 HOH
 2.605
 NE
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ARG B:260 A:412 10.0 0.044 H -64.6 -38.9 10.0 0.044 0.0 CA
 6.993
 NE
 CA
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ARG B:260 A:412 10.0 0.044 H -64.6 -38.9 10.0 0.044 0.0 CA
 6.992
 NE
 CA
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 ARG B:260 A:412 9.0 0.04 H -63.0 -45.1 9.0 0.04 0.0 HOH
 2.396
 NE
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ARG B:260 A:412 6.0 0.027 H -56.1 -49.0 6.0 0.027 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ARG B:260 A:412 7.0 0.031 H -58.6 -48.1 7.0 0.031 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 ARG A:260 A:412 9.0 0.04 H -57.1 -42.7 9.0 0.04 0.0 HOH
 2.719
 NE
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 ARG A:260 A:412 7.0 0.031 H -59.9 -44.1 7.0 0.031 0.0 HOH
 2.732
 NH1
 O
ARG B:260 B:412 7.0 0.031 H -60.2 -44.2 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 ARG B:260 B:412 3.0 0.013 H -58.2 -50.4 3.0 0.013 0.0 HOH
 3.127
 NH1
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 ARG B:260 B:412 3.0 0.013 H -65.8 -57.7 3.0 0.013 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 ARG B:260 B:412 7.0 0.031 H -63.9 -40.7 7.0 0.031 0.0 CA
HOH
 6.753
2.852
 NE
NE
 CA
O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 ARG B:260 B:412 15.0 0.067 H -58.7 -33.1 15.0 0.067 0.0 CA
HOH
 5.087
5.378
 NH1
O
 CA
O
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 ARG B:260 B:412 14.0 0.062 H -63.1 -37.4 14.0 0.062 0.0 CA
HOH
 5.298
2.972
 NH1
NE
 CA
O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 ARG B:260 B:412 3.0 0.013 H -64.0 -40.6 3.0 0.013 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 ARG B:260 B:412 7.0 0.031 H -64.2 -43.9 7.0 0.031 0.0 NA
HOH
 7.103
2.722
 NE
NE
 NA
O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 ARG B:260 B:412 7.0 0.031 H -68.4 -40.0 7.0 0.031 0.0 NA
HOH
 6.951
2.641
 NE
NE
 NA
O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ARG A:412 A:412 103.0 0.458 H -60.3 -47.8 103.0 0.458 0.0 CA
HOH
 4.529
2.882
 NE
NH1
 CA
O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ARG A:412 A:412 91.0 0.404 H -61.2 -36.2 91.0 0.404 0.0 CA
 4.960
 NE
 CA
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ARG A:412 A:412 103.0 0.458 H -60.3 -44.8 103.0 0.458 0.0 CA
HOH
 4.662
2.745
 NE
NH1
 CA
O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ARG A:412 A:412 84.0 0.373 H -62.3 -46.8 84.0 0.373 0.0 CA
HOH
 4.602
3.210
 NE
NH1
 CA
O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 ARG B:260 B:412 50.0 0.222 H -57.5 -44.1 50.0 0.222 0.0 HOH
 3.192
 CD
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ARG B:260 B:412 47.0 0.209 H -61.5 -39.6 47.0 0.209 0.0 HOH
 3.050
 NH2
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ARG B:260 B:412 49.0 0.218 H -61.0 -39.0 49.0 0.218 0.0 HOH
 3.276
 NE
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ARG B:260 B:412 46.0 0.204 H -61.3 -39.1 46.0 0.204 0.0 HOH
 3.327
 NH2
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ARG B:260 B:412 47.0 0.209 H -61.5 -40.3 47.0 0.209 0.0 HOH
 3.183
 CD
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ARG B:260 B:412 53.0 0.236 H -64.1 -40.8 53.0 0.236 0.0 HOH
 3.079
 NE
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ARG B:260 B:412 45.0 0.2 H -65.1 -32.8 45.0 0.2 0.0 HOH
 3.870
 NH1
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ARG B:260 B:412 37.0 0.164 H -58.1 -46.0 37.0 0.164 0.0 HOH
 2.981
 NH1
 O
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ARG A:260 A:412 47.0 0.209 H -60.2 -42.7 47.0 0.209 0.0 CA
HOH
 4.082
3.369
 NH2
CD
 CA
O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ARG A:260 A:412 39.0 0.173 H -60.6 -50.8 39.0 0.173 0.0 CA
HOH
 4.114
3.152
 NH2
NH2
 CA
O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ARG A:260 A:412 34.0 0.151 H -61.0 -51.4 34.0 0.151 0.0 HOH
 4.713
 NH2
 O
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ARG A:260 A:412 33.0 0.147 H -61.6 -43.7 33.0 0.147 0.0 CA
HOH
 3.852
2.732
 NH2
NH2
 CA
O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ARG A:260 A:412 46.0 0.204 H -63.1 -46.5 46.0 0.204 0.0 HOH
 4.091
 NH2
 O
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 ARG A:260 A:412 46.0 0.204 H -70.4 -36.0 46.0 0.204 0.0 CA
HOH
 3.745
4.013
 NH2
NH1
 CA
O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 ARG B:260 B:412 98.0 0.436 H -60.3 -41.3 98.0 0.436 0.0 PG4
HOH
 4.684
2.832
 NH1
NH1
 O1
O
ARG D:260 E:412 48.0 0.213 H -61.5 -40.2 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 ARG A:412 A:412 11.0 0.049 H -63.5 -44.0