Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55523779 . C A CCDS603.1:NM_174936.3:c.1251caC>caA_NP_777596.2:p.417H>Q Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 HIS A:417 NA:NA DO NA DO DO DO NA NA NA
HIS B:417 A:417 65.0 0.333 H -61.1 -42.8 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 HIS A:417 A:417 63.0 0.323 H -62.3 -47.4 63.0 0.323 0.0 HOH
 6.893
 O
 O
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 HIS A:417 A:417 68.0 0.349 H -59.8 -42.1 68.0 0.349 0.0 HOH
 5.595
 CA
 O
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 HIS A:417 A:417 69.0 0.354 H -60.3 -45.5 69.0 0.354 0.0 HOH
 7.315
 HA
 O
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:387 NA:NA DO NA DO DO DO NA NA NA
HIS B:387 B:417 81.0 0.415 H -60.7 -43.0 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:387 NA:NA DO NA DO DO DO NA NA NA
HIS B:387 B:417 54.0 0.277 H -63.9 -44.5 54.0 0.277 0.0 HOH
 3.439
 O
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:387 NA:NA DO NA DO DO DO NA NA NA
HIS B:387 B:417 61.0 0.313 H -61.7 -41.3 61.0 0.313 0.0 HOH
 3.778
 N
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:387 NA:NA DO NA DO DO DO NA NA NA
HIS B:387 B:417 97.0 0.497 H -63.9 -38.7 97.0 0.497 0.0 HOH
 4.692
 ND1
 O
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:387 NA:NA DO NA DO DO DO NA NA NA
HIS B:387 B:417 97.0 0.497 H -63.8 -41.9 97.0 0.497 0.0 HOH
 4.622
 ND1
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:387 NA:NA DO NA DO DO DO NA NA NA
HIS B:387 B:417 52.0 0.267 H -62.1 -38.0 52.0 0.267 0.0 HOH
 3.755
 ND1
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 HIS B:265 B:417 69.0 0.354 H -63.1 -43.0 69.0 0.354 0.0 HOH
 3.053
 ND1
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 HIS B:265 A:417 49.0 0.251 H -61.3 -37.1 49.0 0.251 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 HIS B:265 A:417 50.0 0.256 H -61.2 -37.2 50.0 0.256 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 HIS B:265 A:417 54.0 0.277 H -59.4 -45.2 54.0 0.277 0.0 HOH
 3.638
 N
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 HIS B:265 A:417 63.0 0.323 H -58.1 -45.9 63.0 0.323 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 HIS B:265 A:417 59.0 0.303 H -60.8 -47.5 59.0 0.303 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 HIS A:265 A:417 63.0 0.323 H -63.1 -40.3 63.0 0.323 0.0 HOH
 7.706
 N
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 HIS A:265 A:417 67.0 0.344 H -59.2 -44.6 67.0 0.344 0.0 HOH
 7.459
 N
 O
HIS B:265 B:417 66.0 0.338 H -58.9 -45.6 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 HIS B:265 B:417 69.0 0.354 H -59.0 -47.6 69.0 0.354 0.0 HOH
 5.024
 NE2
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 HIS B:265 B:417 70.0 0.359 H -50.1 -44.1 70.0 0.359 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 HIS B:265 B:417 56.0 0.287 H -64.4 -42.4 56.0 0.287 0.0 HOH
 2.364
 ND1
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 HIS B:265 B:417 57.0 0.292 H -58.7 -45.1 57.0 0.292 0.0 HOH
 3.682
 N
 O
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 HIS B:265 B:417 68.0 0.349 H -62.9 -33.4 68.0 0.349 0.0 HOH
 3.796
 N
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 HIS B:265 B:417 65.0 0.333 H -64.4 -42.4 65.0 0.333 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 HIS B:265 B:417 67.0 0.344 H -64.5 -38.0 67.0 0.344 0.0 HOH
 2.981
 ND1
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 HIS B:265 B:417 69.0 0.354 H -67.3 -39.2 69.0 0.354 0.0 HOH
 2.773
 ND1
 O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 HIS A:417 A:417 116.0 0.595 H -52.7 -42.8 116.0 0.595 0.0 HOH
 5.911
 C
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 HIS A:417 A:417 130.0 0.667 H -56.2 -38.7 130.0 0.667 0.0
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 HIS A:417 A:417 123.0 0.631 H -53.8 -42.6 123.0 0.631 0.0 HOH
 5.407
 O
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 HIS A:417 A:417 128.0 0.656 H -62.2 -34.0 128.0 0.656 0.0 HOH
 6.049
 C
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 HIS B:265 B:417 126.0 0.646 H -57.7 -43.6 126.0 0.646 0.0 HOH
 3.634
 NE2
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 HIS B:265 B:417 129.0 0.662 H -55.4 -47.0 129.0 0.662 0.0 HOH
 3.433
 N
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 HIS B:265 B:417 128.0 0.656 H -57.8 -41.9 128.0 0.656 0.0 HOH
 3.504
 N
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 HIS B:265 B:417 127.0 0.651 H -57.4 -44.0 127.0 0.651 0.0 HOH
 3.615
 N
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 HIS B:265 B:417 125.0 0.641 H -54.3 -47.2 125.0 0.641 0.0 HOH
 3.468
 N
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 HIS B:265 B:417 122.0 0.626 H -55.1 -47.6 122.0 0.626 0.0 HOH
 2.926
 O
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 HIS B:265 B:417 116.0 0.595 H -60.4 -44.4 116.0 0.595 0.0 HOH
 5.890
 C
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 HIS B:265 B:417 142.0 0.728 H -63.4 -48.1 142.0 0.728 0.0 HOH
 6.910
 N
 O
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 HIS A:265 A:417 135.0 0.692 H -59.7 -39.1 135.0 0.692 0.0 HOH
 5.601
 N
 O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 HIS A:265 A:417 130.0 0.667 H -57.9 -47.4 130.0 0.667 0.0 HOH
 6.168
 C
 O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 HIS A:265 A:417 133.0 0.682 H -63.7 -37.2 133.0 0.682 0.0
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 HIS A:265 A:417 127.0 0.651 H -57.0 -46.1 127.0 0.651 0.0 HOH
 3.667
 O
 O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 HIS A:265 A:417 127.0 0.651 H -55.0 -49.0 127.0 0.651 0.0
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 LEU A:265 A:417 122.0 0.718 H -61.1 -41.6 122.0 0.718 0.0 HOH
 7.553
 N
 O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 HIS B:265 B:417 120.0 0.615 H -56.9 -49.0 120.0 0.615 0.0 PG4
HOH
 5.761
7.092
 N
N
 O2
O
HIS D:265 E:417 118.0 0.605 H -57.2 -49.5 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 HIS A:417 A:417 52.0 0.267 H -64.2 -42.3