Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55523798 . A C CCDS603.1:NM_174936.3:c.1270Atc>Ctc_NP_777596.2:p.424I>L Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 ILE A:424 NA:NA DO NA DO DO DO NA NA NA
ILE B:424 A:424 6.0 0.034 S -86.4 131.9 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ILE A:424 A:424 7.0 0.04 S -76.8 135.7 7.0 0.04 0.0 HOH
 8.662
 H
 O
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 ILE A:424 A:424 6.0 0.034 S -64.8 137.3 6.0 0.034 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ILE A:424 A:424 8.0 0.046 S -78.1 136.0 8.0 0.046 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ILE A:394 NA:NA DO NA DO DO DO NA NA NA
ILE B:394 B:424 6.0 0.034 S -86.2 134.7 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ILE A:394 NA:NA DO NA DO DO DO NA NA NA
ILE B:394 B:424 7.0 0.04 S -87.2 131.4 7.0 0.04 0.0 HOH
 7.095
 CG1
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ILE A:394 NA:NA DO NA DO DO DO NA NA NA
ILE B:394 B:424 8.0 0.046 S -84.1 130.8 8.0 0.046 0.0 HOH
 6.905
 CG1
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ILE A:394 NA:NA DO NA DO DO DO NA NA NA
ILE B:394 B:424 6.0 0.034 S -99.6 131.4 6.0 0.034 0.0 HOH
 3.371
 O
 O
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ILE A:394 NA:NA DO NA DO DO DO NA NA NA
ILE B:394 B:424 6.0 0.034 S -99.3 130.3 6.0 0.034 0.0 HOH
 7.181
 CG1
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ILE A:394 NA:NA DO NA DO DO DO NA NA NA
ILE B:394 B:424 6.0 0.034 S -80.0 131.3 6.0 0.034 0.0 HOH
 6.601
 CG1
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 ILE B:272 B:424 5.0 0.029 S -83.5 137.1 5.0 0.029 0.0 HOH
 3.368
 O
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ILE B:272 A:424 8.0 0.046 S -81.7 129.4 8.0 0.046 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ILE B:272 A:424 8.0 0.046 S -81.7 129.4 8.0 0.046 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 ILE B:272 A:424 7.0 0.04 S -84.1 138.9 7.0 0.04 0.0 HOH
 6.750
 C
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ILE B:272 A:424 6.0 0.034 S -88.1 128.9 6.0 0.034 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ILE B:272 A:424 6.0 0.034 S -90.5 130.3 6.0 0.034 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 ILE A:272 A:424 4.0 0.023 S -73.9 124.4 4.0 0.023 0.0
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 ILE A:272 A:424 8.0 0.046 S -89.1 134.3 8.0 0.046 0.0
ILE B:272 B:424 8.0 0.046 S -88.8 134.4 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 ILE B:272 B:424 6.0 0.034 S -56.7 124.5 6.0 0.034 0.0 HOH
 4.630
 O
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 ILE B:272 B:424 6.0 0.034 S -83.6 130.8 6.0 0.034 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 ILE B:272 B:424 6.0 0.034 S -84.3 132.9 6.0 0.034 0.0 HOH
 3.149
 O
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 ILE B:272 B:424 9.0 0.051 S -72.3 144.7 9.0 0.051 0.0 HOH
 6.684
 CG1
 O
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 ILE B:272 B:424 8.0 0.046 S -84.8 130.3 8.0 0.046 0.0 HOH
 7.001
 CG1
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 ILE B:272 B:424 7.0 0.04 S -84.1 132.9 7.0 0.04 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 ILE B:272 B:424 7.0 0.04 S -94.9 133.1 7.0 0.04 0.0 HOH
 3.157
 O
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 ILE B:272 B:424 7.0 0.04 S -94.9 133.1 7.0 0.04 0.0 HOH
 3.846
 N
 O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ILE A:424 A:424 8.0 0.046 S -70.5 141.0 8.0 0.046 0.0 CA
HOH
 9.116
2.732
 O
O
 CA
O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ILE A:424 A:424 8.0 0.046 S -69.8 141.0 8.0 0.046 0.0
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ILE A:424 A:424 8.0 0.046 S -72.9 140.2 8.0 0.046 0.0 HOH
 3.301
 O
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ILE A:424 A:424 7.0 0.04 S -71.3 133.9 7.0 0.04 0.0 HOH
 7.136
 CG1
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 ILE B:272 B:424 6.0 0.034 S -86.9 133.6 6.0 0.034 0.0 HOH
 3.214
 O
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ILE B:272 B:424 7.0 0.04 S -87.6 136.9 7.0 0.04 0.0 HOH
 3.447
 O
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ILE B:272 B:424 8.0 0.046 S -84.5 136.3 8.0 0.046 0.0 HOH
 3.567
 O
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ILE B:272 B:424 7.0 0.04 S -86.6 136.5 7.0 0.04 0.0 HOH
 3.565
 O
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ILE B:272 B:424 6.0 0.034 S -80.6 135.9 6.0 0.034 0.0 HOH
 3.076
 O
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ILE B:272 B:424 3.0 0.017 S -79.9 138.7 3.0 0.017 0.0 HOH
 3.780
 N
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ILE B:272 B:424 8.0 0.046 S -99.0 133.7 8.0 0.046 0.0 HOH
 3.868
 CG1
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ILE B:272 NA:NA DO NA DO DO DO NA NA NA
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ILE A:272 A:424 2.0 0.011 S -85.5 136.0 2.0 0.011 0.0 HOH
 3.563
 N
 O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ILE A:272 A:424 3.0 0.017 S -84.9 134.6 3.0 0.017 0.0 HOH
 3.773
 N
 O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ILE A:272 A:424 2.0 0.011 S -90.5 134.1 2.0 0.011 0.0 HOH
 4.982
 O
 O
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ILE A:272 A:424 1.0 0.006 S -89.6 131.9 1.0 0.006 0.0 HOH
 3.478
 N
 O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ILE A:272 A:424 2.0 0.011 S -81.8 133.3 2.0 0.011 0.0
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 ILE A:272 NA:NA DO NA DO DO DO NA NA NA
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 ILE B:272 B:424 8.0 0.046 S -89.4 133.5 8.0 0.046 0.0 HOH
 5.770
 O
 O
ILE D:272 E:424 9.0 0.051 S -88.8 134.0 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 ILE A:424 A:424 7.0 0.04 S -82.4 130.4