Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55523802 . A C CCDS603.1:NM_174936.3:c.1274aAt>aCt_NP_777596.2:p.425N>T Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 ASN A:425 NA:NA DO NA DO DO DO NA NA NA
ASN B:425 A:425 100.0 0.625 -78.0 104.6 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ASN A:425 A:425 75.0 0.469 -78.9 103.8 75.0 0.469 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 ASN A:425 A:425 76.0 0.475 -84.5 103.4 76.0 0.475 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ASN A:425 A:425 70.0 0.438 -79.0 105.0 70.0 0.438 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASN A:395 NA:NA DO NA DO DO DO NA NA NA
ASN B:395 B:425 99.0 0.619 -81.3 107.2 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASN A:395 NA:NA DO NA DO DO DO NA NA NA
ASN B:395 B:425 102.0 0.637 -79.4 110.3 102.0 0.637 0.0 HOH
 8.797
 O
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASN A:395 NA:NA DO NA DO DO DO NA NA NA
ASN B:395 B:425 82.0 0.512 -80.4 119.3 82.0 0.512 0.0 HOH
 7.962
 ND2
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASN A:395 NA:NA DO NA DO DO DO NA NA NA
ASN B:395 B:425 101.0 0.631 -82.7 116.7 101.0 0.631 0.0 HOH
 3.756
 O
 O
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASN A:395 NA:NA DO NA DO DO DO NA NA NA
ASN B:395 B:425 104.0 0.65 -81.2 115.7 104.0 0.65 0.0
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASN A:395 NA:NA DO NA DO DO DO NA NA NA
ASN B:395 B:425 88.0 0.55 -80.6 110.0 88.0 0.55 0.0 HOH
 3.699
 ND2
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 ASN B:273 B:425 98.0 0.613 -86.5 106.1 98.0 0.613 0.0 HOH
 4.031
 CA
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ASN B:273 A:425 86.0 0.537 -75.5 120.7 86.0 0.537 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ASN B:273 A:425 85.0 0.531 -75.4 120.8 85.0 0.531 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 ASN B:273 A:425 97.0 0.606 -90.0 103.4 97.0 0.606 0.0 HOH
 3.242
 ND2
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ASN B:273 A:425 104.0 0.65 -77.1 111.1 104.0 0.65 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ASN B:273 A:425 102.0 0.637 -71.7 107.5 102.0 0.637 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 ASN A:273 A:425 92.0 0.575 -73.8 102.3 92.0 0.575 0.0
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 ASN A:273 A:425 104.0 0.65 -82.3 104.4 104.0 0.65 0.0
ASN B:273 B:425 104.0 0.65 -83.7 104.4 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 ASN B:273 B:425 99.0 0.619 -78.6 89.8 99.0 0.619 0.0 HOH
 2.809
 ND2
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 ASN B:273 B:425 108.0 0.675 -82.2 100.5 108.0 0.675 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 ASN B:273 B:425 104.0 0.65 -76.4 113.5 104.0 0.65 0.0 HOH
 2.702
 O
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 ASN B:273 B:425 87.0 0.544 -85.8 94.0 87.0 0.544 0.0 HOH
 8.149
 O
 O
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 ASN B:273 B:425 93.0 0.581 -72.4 99.9 93.0 0.581 0.0 HOH
 8.245
 O
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 ASN B:273 B:425 103.0 0.644 -76.4 113.6 103.0 0.644 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 ASN B:273 B:425 98.0 0.613 -81.0 110.5 98.0 0.613 0.0 HOH
 2.922
 O
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 ASN B:273 B:425 99.0 0.619 -80.9 106.2 99.0 0.619 0.0 HOH
 2.784
 OD1
 O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASN A:425 A:425 65.0 0.406 -75.5 107.4 65.0 0.406 0.0 HOH
 3.843
 CA
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASN A:425 A:425 66.0 0.412 -75.4 99.0 66.0 0.412 0.0
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASN A:425 A:425 62.0 0.388 -69.1 97.7 62.0 0.388 0.0 HOH
 2.405
 OD1
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASN A:425 A:425 60.0 0.375 -69.7 101.7 60.0 0.375 0.0 HOH
 9.436
 N
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 ASN B:273 B:425 99.0 0.619 -79.2 109.7 99.0 0.619 0.0 HOH
 2.993
 O
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASN B:273 B:425 104.0 0.65 -81.9 110.5 104.0 0.65 0.0 HOH
 3.802
 CA
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASN B:273 B:425 106.0 0.662 -82.0 112.2 106.0 0.662 0.0 HOH
 3.831
 OD1
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASN B:273 B:425 103.0 0.644 -84.2 110.8 103.0 0.644 0.0 HOH
 3.975
 CA
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASN B:273 B:425 97.0 0.606 -81.5 105.7 97.0 0.606 0.0 HOH
 3.492
 ND2
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASN B:273 B:425 87.0 0.544 -84.2 103.8 87.0 0.544 0.0 HOH
 2.819
 OD1
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ASN B:273 B:425 103.0 0.644 -83.9 106.7 103.0 0.644 0.0 HOH
 7.517
 N
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ASN B:273 NA:NA DO NA DO DO DO NA NA NA
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ASN A:273 A:425 102.0 0.637 -82.4 101.2 102.0 0.637 0.0 HOH
 2.983
 ND2
 O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ASN A:273 A:425 107.0 0.669 -83.0 109.3 107.0 0.669 0.0 HOH
 2.827
 O
 O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ASN A:273 A:425 107.0 0.669 -80.8 105.6 107.0 0.669 0.0 HOH
 3.245
 C
 O
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ASN A:273 A:425 107.0 0.669 -78.1 97.5 107.0 0.669 0.0 HOH
 2.877
 O
 O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ASN A:273 A:425 107.0 0.669 -79.0 105.4 107.0 0.669 0.0 HOH
 8.610
 O
 O
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 ASN A:273 NA:NA DO NA DO DO DO NA NA NA
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 ASN B:273 B:425 91.0 0.569 -74.6 101.3 91.0 0.569 0.0 HOH
 2.899
 ND2
 O
ASN D:273 E:425 94.0 0.588 -74.4 101.2 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 ASN A:425 A:425 74.0 0.463 -76.3 100.8