Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55523812 . G A CCDS603.1:NM_174936.3:c.1284tgG>tgA_NP_777596.2:p.428W>* Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 TRP A:428 NA:NA DO NA DO DO DO NA NA NA
TRP B:428 A:428 47.0 0.184 G -62.6 -36.0 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 TRP A:428 A:428 47.0 0.184 G -61.4 -28.6 47.0 0.184 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 TRP A:428 A:428 45.0 0.176 G -62.8 -31.7 45.0 0.176 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 TRP A:428 A:428 42.0 0.165 G -62.3 -26.1 42.0 0.165 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 TRP A:398 NA:NA DO NA DO DO DO NA NA NA
TRP B:398 B:428 47.0 0.184 G -61.9 -34.5 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 TRP A:398 NA:NA DO NA DO DO DO NA NA NA
TRP B:398 B:428 65.0 0.255 G -71.5 -30.1 65.0 0.255 0.0 HOH
 6.201
 NE1
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 TRP A:398 NA:NA DO NA DO DO DO NA NA NA
TRP B:398 B:428 127.0 0.498 G -67.0 -29.8 127.0 0.498 0.0 HOH
 4.478
 CZ2
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 TRP A:398 NA:NA DO NA DO DO DO NA NA NA
TRP B:398 B:428 45.0 0.176 G -67.7 -35.4 45.0 0.176 0.0 HOH
 3.277
 CB
 O
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 TRP A:398 NA:NA DO NA DO DO DO NA NA NA
TRP B:398 B:428 46.0 0.18 G -70.0 -34.2 46.0 0.18 0.0 HOH
 9.814
 O
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 TRP A:398 NA:NA DO NA DO DO DO NA NA NA
TRP B:398 B:428 56.0 0.22 G -61.9 -30.6 56.0 0.22 0.0 HOH
 2.767
 O
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 TRP B:276 B:428 52.0 0.204 G -64.3 -35.8 52.0 0.204 0.0 HOH
 3.605
 CA
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 TRP B:276 A:428 54.0 0.212 S -73.2 -34.1 54.0 0.212 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 TRP B:276 A:428 54.0 0.212 S -73.2 -34.1 54.0 0.212 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 TRP B:276 A:428 49.0 0.192 G -64.0 -23.1 49.0 0.192 0.0 HOH
 3.289
 NE1
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 TRP B:276 A:428 46.0 0.18 G -64.8 -31.6 46.0 0.18 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 TRP B:276 A:428 43.0 0.169 G -66.5 -30.5 43.0 0.169 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 TRP A:276 A:428 55.0 0.216 G -70.7 -19.6 55.0 0.216 0.0
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 TRP A:276 A:428 48.0 0.188 G -64.5 -34.2 48.0 0.188 0.0
TRP B:276 B:428 48.0 0.188 G -65.7 -33.5 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 TRP B:276 B:428 54.0 0.212 G -58.7 -32.8 54.0 0.212 0.0 HOH
 6.786
 O
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 TRP B:276 B:428 44.0 0.173 G -56.4 -21.4 44.0 0.173 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 TRP B:276 B:428 51.0 0.2 G -64.9 -29.5 51.0 0.2 0.0 HOH
 2.693
 O
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 TRP B:276 B:428 95.0 0.373 G -76.2 -16.6 95.0 0.373 0.0 HOH
 2.630
 O
 O
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 TRP B:276 B:428 97.0 0.38 G -72.5 -25.6 97.0 0.38 0.0 HOH
 2.826
 O
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 TRP B:276 B:428 49.0 0.192 G -64.7 -29.6 49.0 0.192 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 TRP B:276 B:428 48.0 0.188 G -57.8 -35.8 48.0 0.188 0.0 HOH
 2.836
 O
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 TRP B:276 B:428 50.0 0.196 G -55.8 -35.9 50.0 0.196 0.0 HOH
 2.489
 O
 O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 TRP A:428 A:428 29.0 0.114 G -71.2 -31.0 29.0 0.114 0.0 HOH
 5.184
 N
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 TRP A:428 A:428 37.0 0.145 G -84.5 -29.1 37.0 0.145 0.0
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 TRP A:428 A:428 30.0 0.118 G -67.1 -28.2 30.0 0.118 0.0 HOH
 3.577
 NE1
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 TRP A:428 A:428 30.0 0.118 G -73.1 -30.8 30.0 0.118 0.0 HOH
 8.335
 N
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 TRP B:276 B:428 51.0 0.2 G -61.1 -30.9 51.0 0.2 0.0 HOH
 2.675
 O
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 TRP B:276 B:428 48.0 0.188 G -66.5 -34.0 48.0 0.188 0.0 HOH
 3.265
 NE1
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 TRP B:276 B:428 49.0 0.192 G -66.8 -32.8 49.0 0.192 0.0 HOH
 2.763
 O
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 TRP B:276 B:428 48.0 0.188 G -67.4 -32.7 48.0 0.188 0.0 HOH
 2.823
 O
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 TRP B:276 B:428 62.0 0.243 G -66.9 -27.1 62.0 0.243 0.0 HOH
 2.896
 O
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 TRP B:276 B:428 61.0 0.239 G -66.5 -27.9 61.0 0.239 0.0 HOH
 2.598
 O
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 TRP B:276 B:428 57.0 0.224 G -73.8 -34.7 57.0 0.224 0.0 HOH
 6.213
 NE1
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 TRP B:276 NA:NA DO NA DO DO DO NA NA NA
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 TRP A:276 A:428 62.0 0.243 G -66.9 -35.4 62.0 0.243 0.0 HOH
 3.052
 O
 O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 TRP A:276 A:428 50.0 0.196 G -59.2 -37.1 50.0 0.196 0.0 HOH
 2.877
 O
 O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 TRP A:276 A:428 47.0 0.184 G -66.0 -32.0 47.0 0.184 0.0 HOH
 3.240
 O
 O
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 TRP A:276 A:428 48.0 0.188 G -64.8 -30.0 48.0 0.188 0.0 HOH
 3.219
 O
 O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 TRP A:276 A:428 48.0 0.188 G -67.2 -31.9 48.0 0.188 0.0 HOH
 3.344
 O
 O
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 TRP A:276 NA:NA DO NA DO DO DO NA NA NA
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 TRP B:276 B:428 40.0 0.157 G -71.1 -23.3 40.0 0.157 0.0 EDO
HOH
 8.506
3.760
 CH2
NE1
 C1
O
TRP D:276 E:428 52.0 0.204 G -70.4 -24.6 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 TRP A:428 A:428 45.0 0.176 G -69.4 -27.9