Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55523855 . G A CCDS603.1:NM_174936.3:c.1327Gcc>Acc_NP_777596.2:p.443A>T Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 ALA A:443 NA:NA DO NA DO DO DO NA NA NA
ALA B:443 A:443 13.0 0.113 -149.6 154.2 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ALA A:443 A:443 38.0 0.33 -163.3 152.5 17.0 0.148 0.182 B:None:0.183
 HOH
 7.767
 HB3
 O
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 ALA A:443 A:443 38.0 0.33 -156.3 154.4 16.0 0.139 0.191 D:None:0.191
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ALA A:443 A:443 38.0 0.33 -168.8 148.2 18.0 0.157 0.173 B:None:0.174
 HOH
 7.466
 HB2
 O
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ALA A:413 NA:NA DO NA DO DO DO NA NA NA
ALA B:413 B:443 12.0 0.104 -153.2 155.7 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ALA A:413 NA:NA DO NA DO DO DO NA NA NA
ALA B:413 B:443 9.0 0.078 -157.6 154.5 9.0 0.078 0.0 HOH
 2.711
 O
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ALA A:413 NA:NA DO NA DO DO DO NA NA NA
ALA B:413 B:443 8.0 0.07 -150.9 154.8 8.0 0.07 0.0 HOH
 2.761
 O
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ALA A:413 NA:NA DO NA DO DO DO NA NA NA
ALA B:413 B:443 10.0 0.087 -156.4 159.9 10.0 0.087 0.0
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ALA A:413 NA:NA DO NA DO DO DO NA NA NA
ALA B:413 B:443 11.0 0.096 -154.9 158.9 11.0 0.096 0.0 HOH
 5.761
 CA
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ALA A:413 NA:NA DO NA DO DO DO NA NA NA
ALA B:413 B:443 10.0 0.087 -157.3 147.1 10.0 0.087 0.0 HOH
 4.090
 CB
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 ALA B:291 B:443 11.0 0.096 -159.9 149.5 11.0 0.096 0.0 HOH
 3.712
 CB
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ALA B:291 A:443 15.0 0.13 -151.4 151.0 15.0 0.13 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ALA B:291 A:443 19.0 0.165 -151.5 151.0 19.0 0.165 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 ALA B:291 A:443 9.0 0.078 -154.7 150.6 9.0 0.078 0.0 HOH
 2.576
 O
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ALA B:291 A:443 10.0 0.087 -156.0 147.4 10.0 0.087 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ALA B:291 A:443 11.0 0.096 -153.0 152.3 11.0 0.096 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 ALA A:291 A:443 13.0 0.113 -156.2 155.3 13.0 0.113 0.0
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 ALA A:291 A:443 14.0 0.122 -150.3 154.0 14.0 0.122 0.0
ALA B:291 B:443 13.0 0.113 -150.3 152.7 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 ALA B:291 B:443 13.0 0.113 -152.9 143.9 13.0 0.113 0.0 HOH
 6.628
 CB
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 ALA B:291 B:443 42.0 0.365 -151.7 147.5 42.0 0.365 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 ALA B:291 B:443 12.0 0.104 -151.5 154.4 12.0 0.104 0.0 HOH
 2.831
 O
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 ALA B:291 B:443 8.0 0.07 -155.5 152.2 8.0 0.07 0.0 HOH
 2.649
 O
 O
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 ALA B:291 B:443 9.0 0.078 -160.2 152.7 9.0 0.078 0.0 HOH
 2.724
 O
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 ALA B:291 B:443 12.0 0.104 -151.5 154.4 12.0 0.104 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 ALA B:291 B:443 10.0 0.087 -150.7 150.8 10.0 0.087 0.0 HOH
 2.780
 O
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 ALA B:291 B:443 10.0 0.087 -152.4 148.0 10.0 0.087 0.0 HOH
 2.745
 O
 O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ALA A:443 A:443 34.0 0.296 -146.9 145.0 17.0 0.148 0.148 B:None:0.148
 HOH
 2.830
 N
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ALA A:443 A:443 36.0 0.313 -154.4 145.4 16.0 0.139 0.174 B:None:0.174
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ALA A:443 A:443 38.0 0.33 -149.5 147.6 16.0 0.139 0.191 C:None:0.191
 HOH
 2.807
 N
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ALA A:443 A:443 37.0 0.322 -160.3 145.4 15.0 0.13 0.192 B:None:0.191
 HOH
 2.653
 O
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 ALA B:291 B:443 13.0 0.113 -156.2 154.8 13.0 0.113 0.0 HOH
 2.939
 O
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ALA B:291 B:443 12.0 0.104 -157.9 151.4 12.0 0.104 0.0 HOH
 2.909
 O
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ALA B:291 B:443 13.0 0.113 -153.8 158.0 13.0 0.113 0.0 HOH
 2.783
 O
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ALA B:291 B:443 12.0 0.104 -156.5 153.6 12.0 0.104 0.0 HOH
 2.838
 O
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ALA B:291 B:443 13.0 0.113 -154.1 154.5 13.0 0.113 0.0 HOH
 2.801
 O
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ALA B:291 B:443 13.0 0.113 -155.1 156.6 13.0 0.113 0.0 HOH
 2.847
 O
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ALA B:291 B:443 11.0 0.096 -152.3 155.3 11.0 0.096 0.0 HOH
 2.743
 O
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ALA B:291 NA:NA DO NA DO DO DO NA NA NA
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ALA A:291 A:443 13.0 0.113 -152.8 148.7 13.0 0.113 0.0 HOH
 2.808
 O
 O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ALA A:291 A:443 13.0 0.113 -154.7 148.4 13.0 0.113 0.0 HOH
 2.563
 O
 O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ALA A:291 A:443 14.0 0.122 -160.2 144.3 14.0 0.122 0.0
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ALA A:291 A:443 13.0 0.113 -148.2 154.0 13.0 0.113 0.0 HOH
 2.571
 O
 O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ALA A:291 A:443 13.0 0.113 -154.1 155.9 13.0 0.113 0.0
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 ALA A:291 NA:NA DO NA DO DO DO NA NA NA
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 ALA B:291 B:443 9.0 0.078 -153.8 157.1 9.0 0.078 0.0
ALA D:291 E:443 9.0 0.078 -154.4 155.8 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 ALA A:443 A:443 17.0 0.148 -143.6 157.2