Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55524211 . C A CCDS603.1:NM_174936.3:c.1394tCg>tAg_NP_777596.2:p.465S>* Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 SER A:465 NA:NA DO NA DO DO DO NA NA NA
SER B:465 A:465 24.0 0.209 -67.7 -26.0 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 SER A:465 A:465 9.0 0.078 -77.8 174.1 9.0 0.078 0.0 HOH
 8.052
 N
 O
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 SER A:465 A:465 8.0 0.07 -76.7 179.2 8.0 0.07 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 SER A:465 A:465 9.0 0.078 -75.7 177.5 9.0 0.078 0.0 HOH
 7.600
 HA
 O
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 SER A:435 NA:NA DO NA DO DO DO NA NA NA
SER B:435 B:465 27.0 0.235 -72.3 -46.8 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 SER A:435 NA:NA DO NA DO DO DO NA NA NA
SER B:435 B:465 24.0 0.209 -56.6 -41.5 24.0 0.209 0.0 HOH
 5.068
 CA
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 SER A:435 NA:NA DO NA DO DO DO NA NA NA
SER B:435 B:465 22.0 0.191 -60.4 -34.1 22.0 0.191 0.0 HOH
 5.138
 CA
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 SER A:435 NA:NA DO NA DO DO DO NA NA NA
SER B:435 B:465 26.0 0.226 -69.2 -33.3 26.0 0.226 0.0 PVM
 9.973
 N
 N30
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 SER A:435 NA:NA DO NA DO DO DO NA NA NA
SER B:435 B:465 28.0 0.243 -64.1 -42.9 28.0 0.243 0.0 PVJ
HOH
 9.804
5.173
 N
CA
 C28
O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 SER A:435 NA:NA DO NA DO DO DO NA NA NA
SER B:435 B:465 22.0 0.191 -56.1 -44.5 22.0 0.191 0.0
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 SER B:313 B:465 28.0 0.243 -68.3 -38.2 28.0 0.243 0.0 HOH
 2.901
 O
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 SER B:313 A:465 28.0 0.243 -64.0 -55.1 28.0 0.243 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 SER B:313 A:465 30.0 0.261 -63.9 -55.2 30.0 0.261 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 SER B:313 A:465 21.0 0.183 -65.1 -34.2 21.0 0.183 0.0 HOH
 8.235
 N
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 SER B:313 A:465 19.0 0.165 -68.5 -25.8 19.0 0.165 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 SER B:313 A:465 19.0 0.165 -68.7 -30.2 19.0 0.165 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 SER A:313 A:465 16.0 0.139 -67.3 -44.7 16.0 0.139 0.0 HOH
 4.105
 OG
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 SER A:313 A:465 23.0 0.2 -69.4 -29.4 23.0 0.2 0.0
SER B:313 B:465 23.0 0.2 -69.6 -30.6 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 SER B:313 B:465 17.0 0.148 -60.1 -32.1 17.0 0.148 0.0 HOH
 3.843
 O
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 SER B:313 NA:NA DO NA DO DO DO NA NA NA
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 SER B:313 B:465 26.0 0.226 -65.1 -19.7 26.0 0.226 0.0 HOH
 2.544
 O
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 SER B:313 B:465 37.0 0.322 -81.4 -72.9 37.0 0.322 0.0
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 SER B:313 B:465 27.0 0.235 -97.3 -35.4 27.0 0.235 0.0 HOH
 9.409
 N
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 SER B:313 B:465 25.0 0.217 -65.0 -19.9 25.0 0.217 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 SER B:313 B:465 24.0 0.209 -79.9 -33.7 24.0 0.209 0.0 HOH
 5.840
 CA
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 SER B:313 B:465 20.0 0.174 -77.6 -23.0 20.0 0.174 0.0 HOH
 3.031
 O
 O
7anq 1 Q8NBP7 100.0 6e-167 X-RAY
 2021-10-20 SER A:14 A:465 26.0 0.226 -73.5 -40.7 26.0 0.226 0.0 HOH
 3.871
 CA
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 SER A:465 A:465 7.0 0.061 -69.0 160.9