Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55524222 . C A CCDS603.1:NM_174936.3:c.1405Cgg>Agg_NP_777596.2:p.469R>R Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 ARG A:469 NA:NA DO NA DO DO DO NA NA NA
ARG B:469 A:469 171.0 0.76 T -63.6 -23.8 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ARG A:469 A:469 116.0 0.516 T -65.7 -26.5 116.0 0.516 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 ARG A:469 A:469 109.0 0.484 T -63.5 -21.5 109.0 0.484 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ARG A:469 A:469 114.0 0.507 T -62.1 -22.7 114.0 0.507 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:439 NA:NA DO NA DO DO DO NA NA NA
ARG B:439 B:469 46.0 NA S -73.0 -20.9 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:439 NA:NA DO NA DO DO DO NA NA NA
ARG B:439 NA:NA DO NA DO DO DO NA NA NA
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:439 NA:NA DO NA DO DO DO NA NA NA
ARG B:439 B:469 157.0 0.698 T -63.2 -29.0 157.0 0.698 0.0 HOH
 7.551
 O
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:439 NA:NA DO NA DO DO DO NA NA NA
ARG B:439 B:469 50.0 NA T -65.1 -29.7 50.0 NA NA
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:439 NA:NA DO NA DO DO DO NA NA NA
ARG B:439 B:469 50.0 NA T -65.1 -25.8 50.0 NA NA
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:439 NA:NA DO NA DO DO DO NA NA NA
ARG B:439 B:469 59.0 0.262 S -83.0 -35.4 59.0 0.262 0.0
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 ARG B:317 B:469 172.0 0.764 T -64.3 -43.7 172.0 0.764 0.0 HOH
 6.100
 N
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ARG B:317 A:469 166.0 0.738 T -66.0 -45.0 166.0 0.738 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ARG B:317 A:469 166.0 0.738 T -66.0 -45.0 166.0 0.738 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 ARG B:317 A:469 140.0 0.622 T -74.2 138.6 140.0 0.622 0.0 HOH
 5.152
 CB
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ARG B:317 A:469 169.0 0.751 T -65.3 140.2 169.0 0.751 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ARG B:317 A:469 161.0 0.716 T -66.6 140.5 161.0 0.716 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 ARG A:317 A:469 184.0 0.818 S -58.6 -29.7 184.0 0.818 0.0 HOH
 3.309
 O
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 ARG A:317 A:469 170.0 0.756 T -58.2 -25.3 170.0 0.756 0.0
ARG B:317 B:469 170.0 0.756 T -57.2 -25.2 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 ARG B:317 B:469 134.0 0.596 S -69.9 -40.4 134.0 0.596 0.0
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 ARG B:317 NA:NA DO NA DO DO DO NA NA NA
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 ARG B:317 B:469 100.0 0.444 T -55.8 -40.3 100.0 0.444 0.0 HOH
 5.957
 N
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 ARG B:317 B:469 135.0 0.6 S -82.4 -22.0 135.0 0.6 0.0
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 ARG B:317 B:469 125.0 0.556 T -74.7 -17.7 125.0 0.556 0.0
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 ARG B:317 B:469 100.0 0.444 T -55.8 -40.4 100.0 0.444 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 ARG B:317 B:469 147.0 0.653 T -72.7 -28.0 147.0 0.653 0.0
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 ARG B:317 B:469 20.0 0.089 T -107.0 21.8 20.0 0.089 0.0 HOH
 4.598
 O
 O
7anq 1 Q8NBP7 100.0 6e-167 X-RAY
 2021-10-20 ARG A:18 A:469 83.0 0.369 T -66.6 -32.6 83.0 0.369 0.0 HOH
 3.224
 N
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 ARG A:469 A:469 114.0 0.507 T -58.7 -24.2