Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr1 | 55524237 | . | G | A | CCDS603.1:NM_174936.3:c.1420Gtc>Atc_NP_777596.2:p.474V>I | Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 2p4e | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2007-04-10 | ILE | A:474 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ILE | B:474 | A:474 | 41.0 | 0.234 | E | -124.6 | 126.9 | NA | NA | NA | |||||||||||||
| 6u2f | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | ILE | A:474 | A:474 | 43.0 | 0.246 | E | -126.9 | 124.1 | 43.0 | 0.246 | 0.0 | ||||||
| 5vlp | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2017-08-16 | ILE | A:474 | A:474 | 36.0 | 0.206 | E | -140.0 | 122.4 | 36.0 | 0.206 | 0.0 | ||||||
| 6u3i | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | ILE | A:474 | A:474 | 44.0 | 0.251 | E | -127.5 | 129.6 | 44.0 | 0.251 | 0.0 |
HOH |
2.837 |
O |
O |
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| 6u26 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ILE | A:444 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ILE | B:444 | B:474 | 81.0 | 0.463 | E | -121.4 | 128.9 | NA | NA | NA | |||||||||||||
| 6u2n | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ILE | A:444 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ILE | B:444 | B:474 | 69.0 | 0.394 | E | -127.0 | 124.3 | 69.0 | 0.394 | 0.0 |
PV7 HOH |
3.818 3.027 |
O N |
O27 O |
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| 6u2p | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ILE | A:444 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ILE | B:444 | B:474 | 74.0 | 0.423 | E | -122.9 | 125.8 | 74.0 | 0.423 | 0.0 |
PUV HOH |
3.494 3.048 |
O N |
F O |
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| 6u36 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ILE | A:444 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ILE | B:444 | B:474 | 70.0 | 0.4 | E | -124.6 | 123.8 | 70.0 | 0.4 | 0.0 |
PVM |
3.426 |
O |
F |
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| 6u38 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ILE | A:444 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ILE | B:444 | B:474 | 59.0 | 0.337 | E | -123.8 | 127.9 | 59.0 | 0.337 | 0.0 |
PVJ HOH |
3.466 3.248 |
O N |
F O |
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| 6u3x | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ILE | A:444 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ILE | B:444 | B:474 | 44.0 | 0.251 | E | -125.7 | 117.0 | 44.0 | 0.251 | 0.0 |
PVV |
6.846 |
O |
C15 |
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| 2pmw | 2 | Q5SZQ2 | 100.0 | 0.0 |
X-RAY |
2007-05-08 | VAL | B:322 | B:474 | 34.0 | 0.219 | E | -124.0 | 131.2 | 34.0 | 0.219 | 0.0 |
HOH |
3.162 |
N |
O |
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| 3p5b | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | ILE | B:322 | A:474 | 53.0 | 0.303 | E | -120.5 | 122.5 | 53.0 | 0.303 | 0.0 | ||||||
| 3p5c | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | ILE | B:322 | A:474 | 55.0 | 0.314 | E | -120.5 | 122.5 | 55.0 | 0.314 | 0.0 | ||||||
| 3bps | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2008-02-12 | ILE | B:322 | A:474 | 48.0 | 0.274 | E | -128.4 | 128.8 | 48.0 | 0.274 | 0.0 |
HOH |
2.977 |
O |
O |
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| 3gcw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | ILE | B:322 | A:474 | 50.0 | 0.286 | E | -128.3 | 128.1 | 50.0 | 0.286 | 0.0 | ||||||
| 3gcx | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | ILE | B:322 | A:474 | 58.0 | 0.331 | E | -127.8 | 126.6 | 58.0 | 0.331 | 0.0 | ||||||
| 3sqo | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2012-05-16 | ILE | A:322 | A:474 | 51.0 | 0.291 | E | -125.6 | 136.0 | 51.0 | 0.291 | 0.0 |
HOH |
3.393 |
CD1 |
O |
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| 4ne9 | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2014-09-10 | ILE | A:322 | A:474 | 31.0 | NA | E | -123.8 | 127.8 | 31.0 | NA | NA | ||||||
| ILE | B:322 | B:474 | 31.0 | NA | E | -130.3 | 122.8 | NA | NA | NA | |||||||||||||
| 4k8r | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2013-05-08 | ILE | B:322 | B:474 | 56.0 | 0.32 | E | -125.8 | 116.7 | 56.0 | 0.32 | 0.0 |
HOH |
3.340 |
O |
O |
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| 5vl7 | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2017-08-16 | ILE | B:322 | B:474 | 47.0 | 0.269 | E | -120.0 | 129.6 | 47.0 | 0.269 | 0.0 | ||||||
| 2qtw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2007-09-18 | ILE | B:322 | B:474 | 39.0 | 0.223 | E | -122.9 | 123.8 | 39.0 | 0.223 | 0.0 |
HOH |
3.066 |
O |
O |
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| 7kev | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-24 | ILE | B:322 | B:474 | 49.0 | 0.28 | E | -133.1 | 122.5 | 49.0 | 0.28 | 0.0 | ||||||
| 7kfa | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-10 | ILE | B:322 | B:474 | 42.0 | 0.24 | E | -130.4 | 122.3 | 42.0 | 0.24 | 0.0 |
HOH |
7.957 |
O |
O |
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| 3m0c | 2 | Q8NBP7 | 99.44 | 0.0 |
X-RAY |
2011-03-16 | ILE | B:322 | B:474 | 40.0 | 0.229 | E | -122.9 | 123.8 | 40.0 | 0.229 | 0.0 | ||||||
| 3h42 | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2009-05-05 | ILE | B:322 | B:474 | 44.0 | 0.251 | E | -128.0 | 129.3 | 44.0 | 0.251 | 0.0 |
HOH |
3.072 |
N |
O |
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| 5oca | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2017-09-20 | ILE | B:322 | B:474 | 44.0 | 0.251 | E | -135.1 | 128.4 | 44.0 | 0.251 | 0.0 |
HOH |
3.988 |
O |
O |
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| 7anq | 1 | Q8NBP7 | 100.0 | 6e-167 |
X-RAY |
2021-10-20 | VAL | A:23 | A:474 | 46.0 | 0.297 | E | -124.1 | 123.9 | 35.0 | 0.226 | 0.071 |
B:None:0.071 |
HOH |
2.809 |
O |
O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q8nbp7-f1 | 1 | Q8NBP7 | 100.0 | 0.0 | VAL | A:474 | A:474 | 30.0 | 0.194 | E | -132.7 | 123.0 | |