Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55524300 . C A CCDS603.1:NM_174936.3:c.1483Cgg>Agg_NP_777596.2:p.495R>R Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 ARG A:495 NA:NA DO NA DO DO DO NA NA NA
ARG B:495 A:495 36.0 0.16 E -141.3 152.5 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ARG A:495 A:495 38.0 0.169 E -137.0 146.0 38.0 0.169 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 ARG A:495 A:495 67.0 0.298 E -129.4 143.3 67.0 0.298 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ARG A:495 A:495 39.0 0.173 E -131.4 148.9 39.0 0.173 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:465 NA:NA DO NA DO DO DO NA NA NA
ARG B:465 B:495 33.0 0.147 E -133.1 159.5 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:465 NA:NA DO NA DO DO DO NA NA NA
ARG B:465 B:495 31.0 0.138 E -139.4 163.7 31.0 0.138 0.0 HOH
 3.981
 NH2
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:465 NA:NA DO NA DO DO DO NA NA NA
ARG B:465 B:495 27.0 0.12 E -147.5 163.4 27.0 0.12 0.0 HOH
 3.647
 NH2
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:465 NA:NA DO NA DO DO DO NA NA NA
ARG B:465 B:495 29.0 0.129 E -145.9 164.2 29.0 0.129 0.0
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:465 NA:NA DO NA DO DO DO NA NA NA
ARG B:465 B:495 35.0 0.156 E -142.3 167.0 35.0 0.156 0.0 HOH
 4.116
 NH1
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:465 NA:NA DO NA DO DO DO NA NA NA
ARG B:465 B:495 24.0 0.107 E -139.4 161.5 24.0 0.107 0.0 HOH
 3.423
 NH2
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 ARG B:343 B:495 33.0 0.147 E -149.5 157.6 33.0 0.147 0.0 HOH
 2.952
 NH1
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ARG B:343 A:495 33.0 0.147 E -152.8 139.5 33.0 0.147 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ARG B:343 A:495 32.0 0.142 E -152.8 139.4 32.0 0.142 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 ARG B:343 A:495 61.0 0.271 E -140.1 160.9 61.0 0.271 0.0 HOH
 8.851
 NH1
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ARG B:343 A:495 63.0 0.28 E -143.4 161.9 63.0 0.28 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ARG B:343 A:495 63.0 0.28 E -145.2 160.9 63.0 0.28 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 ARG A:343 A:495 26.0 0.116 E -164.4 155.2 26.0 0.116 0.0 HOH
 4.307
 NH1
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 ARG A:343 A:495 35.0 0.156 E -141.3 153.5 35.0 0.156 0.0
ARG B:343 B:495 36.0 0.16 E -141.2 153.8 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 ARG B:343 B:495 36.0 0.16 E -145.4 145.0 36.0 0.16 0.0 HOH
 8.812
 NH1
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 ARG B:343 NA:NA DO NA DO DO DO NA NA NA
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 ARG B:343 B:495 29.0 0.129 E -149.7 137.7 29.0 0.129 0.0 HOH
 2.656
 CG
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 ARG B:343 B:495 30.0 0.133 E -137.2 153.8 30.0 0.133 0.0
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 ARG B:343 B:495 26.0 0.116 E -144.1 155.4 26.0 0.116 0.0 HOH
 3.143
 NH2
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 ARG B:343 B:495 29.0 0.129 E -149.7 137.7 29.0 0.129 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 ARG B:343 B:495 40.0 0.178 E -146.1 164.7 40.0 0.178 0.0 HOH
 3.690
 NH2
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 ARG B:343 B:495 28.0 0.124 E -134.8 164.9 28.0 0.124 0.0 HOH
 3.539
 NH2
 O
7anq 1 Q8NBP7 100.0 6e-167 X-RAY
 2021-10-20 ARG A:44 A:495 34.0 0.151 E -125.8 165.1 34.0 0.151 0.0 HOH
 2.884
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 ARG A:495 A:495 35.0 0.156 E -139.8 141.9