Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55524304 . G A CCDS603.1:NM_174936.3:c.1487cGg>cAg_NP_777596.2:p.496R>Q Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 ARG A:496 NA:NA DO NA DO DO DO NA NA NA
ARG B:496 A:496 58.0 0.258 E -109.4 22.8 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ARG A:496 A:496 31.0 0.138 E -92.7 -2.2 31.0 0.138 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 ARG A:496 A:496 13.0 0.058 E -92.5 -8.7 13.0 0.058 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ARG A:496 A:496 31.0 0.138 E -96.0 -5.6 31.0 0.138 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:466 NA:NA DO NA DO DO DO NA NA NA
ARG B:466 B:496 30.0 0.133 E -117.3 19.7 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:466 NA:NA DO NA DO DO DO NA NA NA
ARG B:466 B:496 43.0 0.191 E -116.7 21.3 43.0 0.191 0.0 HOH
 4.562
 NH2
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:466 NA:NA DO NA DO DO DO NA NA NA
ARG B:466 B:496 39.0 0.173 E -117.1 30.3 39.0 0.173 0.0 HOH
 3.013
 NH2
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:466 NA:NA DO NA DO DO DO NA NA NA
ARG B:466 B:496 32.0 0.142 E -121.5 28.7 32.0 0.142 0.0
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:466 NA:NA DO NA DO DO DO NA NA NA
ARG B:466 B:496 31.0 0.138 E -121.9 31.0 31.0 0.138 0.0 HOH
 8.579
 C
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:466 NA:NA DO NA DO DO DO NA NA NA
ARG B:466 B:496 34.0 0.151 E -112.1 36.2 34.0 0.151 0.0 HOH
 8.541
 C
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 ARG B:344 B:496 8.0 0.036 E -114.7 20.9 8.0 0.036 0.0 HOH
 6.608
 NH2
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ARG B:344 A:496 15.0 0.067 E -108.8 27.0 15.0 0.067 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ARG B:344 A:496 17.0 0.076 E -108.8 27.1 17.0 0.076 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 ARG B:344 A:496 86.0 0.382 E -112.0 159.6 86.0 0.382 0.0 HOH
 7.972
 O
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ARG B:344 A:496 176.0 0.782 E -148.8 162.7 176.0 0.782 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ARG B:344 A:496 172.0 0.764 E -147.9 162.6 172.0 0.764 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 ARG A:344 A:496 39.0 0.173 E -102.6 9.6 39.0 0.173 0.0 HOH
 3.098
 CD
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 ARG A:344 A:496 55.0 0.244 E -108.4 22.5 55.0 0.244 0.0
ARG B:344 B:496 62.0 0.276 E -108.0 22.4 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 ARG B:344 B:496 17.0 0.076 E -98.6 12.5 17.0 0.076 0.0
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 ARG B:344 NA:NA DO NA DO DO DO NA NA NA
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 ARG B:344 B:496 26.0 0.116 E -108.6 22.6 26.0 0.116 0.0 HOH
 3.611
 NH1
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 ARG B:344 B:496 30.0 0.133 E -117.7 20.1 30.0 0.133 0.0
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 ARG B:344 B:496 20.0 0.089 E -112.2 21.6 20.0 0.089 0.0 HOH
 5.917
 C
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 ARG B:344 B:496 25.0 0.111 E -108.6 22.5 25.0 0.111 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 ARG B:344 B:496 10.0 0.044 E -116.8 28.4 10.0 0.044 0.0 HOH
 5.871
 C
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 ARG B:344 B:496 37.0 0.164 E -117.2 26.6 37.0 0.164 0.0 HOH
 3.105
 NH2
 O
7anq 1 Q8NBP7 100.0 6e-167 X-RAY
 2021-10-20 ARG A:45 A:496 5.0 0.022 E -118.0 27.8 5.0 0.022 0.0 HOH
 3.567
 CD
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 ARG A:496 A:496 28.0 0.124 E -85.5 6.7