Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr1 | 55524312 | . | C | A | CCDS603.1:NM_174936.3:c.1495Cgc>Agc_NP_777596.2:p.499R>S | Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 2p4e | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2007-04-10 | ARG | A:499 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:499 | A:499 | 78.0 | 0.347 | E | -146.0 | 150.2 | NA | NA | NA | |||||||||||||
| 6u2f | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | ARG | A:499 | A:499 | 60.0 | 0.267 | E | -139.1 | 134.7 | 54.0 | 0.24 | 0.027 |
C:Q569X1:0.027 |
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| 5vlp | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2017-08-16 | ARG | A:499 | A:499 | 62.0 | 0.276 | E | -142.3 | 141.9 | 56.0 | 0.249 | 0.027 |
B:None:0.027 |
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| 6u3i | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | ARG | A:499 | A:499 | 69.0 | 0.307 | E | -141.4 | 132.1 | 66.0 | 0.293 | 0.014 |
C:None:0.013 |
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| 6u26 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:469 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:469 | B:499 | 67.0 | 0.298 | E | -145.3 | 144.7 | NA | NA | NA | |||||||||||||
| 6u2n | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:469 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:469 | B:499 | 77.0 | 0.342 | E | -140.9 | 144.7 | 77.0 | 0.342 | 0.0 |
HOH |
3.824 |
NH1 |
O |
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| 6u2p | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:469 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:469 | B:499 | 74.0 | 0.329 | E | -145.7 | 148.5 | 74.0 | 0.329 | 0.0 |
HOH |
7.133 |
CD |
O |
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| 6u36 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:469 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:469 | B:499 | 71.0 | 0.316 | E | -152.8 | 150.2 | 71.0 | 0.316 | 0.0 | |||||||||||||
| 6u38 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:469 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:469 | B:499 | 77.0 | 0.342 | E | -154.7 | 154.4 | 77.0 | 0.342 | 0.0 |
HOH |
8.409 |
N |
O |
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| 6u3x | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:469 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:469 | B:499 | 42.0 | 0.187 | E | -139.4 | 145.4 | 42.0 | 0.187 | 0.0 |
HOH |
8.743 |
N |
O |
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| 2pmw | 2 | Q5SZQ2 | 100.0 | 0.0 |
X-RAY |
2007-05-08 | ARG | B:347 | B:499 | 58.0 | 0.258 | E | -136.9 | 153.3 | 58.0 | 0.258 | 0.0 |
HOH |
5.076 |
NH1 |
O |
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| 3p5b | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | ARG | B:347 | A:499 | 47.0 | 0.209 | E | -144.7 | 145.8 | 47.0 | 0.209 | 0.0 | ||||||
| 3p5c | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | ARG | B:347 | A:499 | 48.0 | 0.213 | E | -144.8 | 145.8 | 48.0 | 0.213 | 0.0 | ||||||
| 3bps | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2008-02-12 | ARG | B:347 | A:499 | 160.0 | 0.711 | E | -132.1 | 144.5 | 160.0 | 0.711 | 0.0 |
HOH |
4.054 |
CA |
O |
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| 3gcw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | ARG | B:347 | A:499 | 99.0 | 0.44 | E | -145.1 | 158.9 | 99.0 | 0.44 | 0.0 | ||||||
| 3gcx | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | ARG | B:347 | A:499 | 104.0 | 0.462 | E | -161.6 | 160.0 | 104.0 | 0.462 | 0.0 | ||||||
| 3sqo | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2012-05-16 | ARG | A:347 | A:499 | 81.0 | 0.36 | E | -142.9 | 151.1 | 81.0 | 0.36 | 0.0 |
HOH |
6.404 |
CD |
O |
||
| 4ne9 | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2014-09-10 | ARG | A:347 | A:499 | 79.0 | 0.351 | E | -147.4 | 150.3 | 79.0 | 0.351 | 0.0 | ||||||
| ARG | B:347 | B:499 | 81.0 | 0.36 | E | -147.2 | 150.3 | NA | NA | NA | |||||||||||||
| 4k8r | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2013-05-08 | ARG | B:347 | B:499 | 55.0 | 0.244 | E | -135.0 | 144.9 | 55.0 | 0.244 | 0.0 |
HOH |
9.552 |
NH1 |
O |
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| 5vl7 | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2017-08-16 | ARG | B:347 | B:499 | 77.0 | 0.342 | E | -129.8 | 150.4 | 77.0 | 0.342 | 0.0 | ||||||
| 2qtw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2007-09-18 | ARG | B:347 | B:499 | 75.0 | 0.333 | E | -148.2 | 151.8 | 75.0 | 0.333 | 0.0 |
HOH |
3.112 |
NH1 |
O |
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| 7kev | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-24 | ARG | B:347 | B:499 | 51.0 | 0.227 | E | -157.0 | 151.1 | 51.0 | 0.227 | 0.0 | ||||||
| 7kfa | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-10 | ARG | B:347 | B:499 | 64.0 | 0.284 | E | -157.5 | 155.1 | 64.0 | 0.284 | 0.0 |
HOH |
7.802 |
N |
O |
||
| 3m0c | 2 | Q8NBP7 | 99.44 | 0.0 |
X-RAY |
2011-03-16 | ARG | B:347 | B:499 | 73.0 | 0.324 | E | -148.2 | 151.7 | 73.0 | 0.324 | 0.0 | ||||||
| 3h42 | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2009-05-05 | ARG | B:347 | B:499 | 80.0 | 0.356 | E | -146.7 | 154.2 | 80.0 | 0.356 | 0.0 |
HOH |
7.088 |
C |
O |
||
| 5oca | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2017-09-20 | ARG | B:347 | B:499 | 73.0 | 0.324 | E | -152.6 | 136.6 | 73.0 | 0.324 | 0.0 |
HOH |
7.202 |
C |
O |
||
| 7anq | 1 | Q8NBP7 | 100.0 | 6e-167 |
X-RAY |
2021-10-20 | ARG | A:48 | A:499 | 75.0 | 0.333 | E | -145.9 | 145.4 | 75.0 | 0.333 | 0.0 |
HOH |
2.789 |
NH1 |
O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q8nbp7-f1 | 1 | Q8NBP7 | 100.0 | 0.0 | ARG | A:499 | A:499 | 61.0 | 0.271 | E | -133.0 | 145.3 | |