Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr1 | 55525183 | . | C | A | CCDS603.1:NM_174936.3:c.1528Cgg>Agg_NP_777596.2:p.510R>R | Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 2p4e | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2007-04-10 | ARG | A:510 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:510 | A:510 | 38.0 | 0.169 | E | -116.1 | 127.1 | NA | NA | NA | |||||||||||||
| 6u2f | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | ARG | A:510 | A:510 | 45.0 | 0.2 | E | -105.5 | 107.5 | 45.0 | 0.2 | 0.0 | ||||||
| 5vlp | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2017-08-16 | ARG | A:510 | A:510 | 39.0 | 0.173 | E | -102.0 | 121.1 | 39.0 | 0.173 | 0.0 | ||||||
| 6u3i | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | ARG | A:510 | A:510 | 34.0 | 0.151 | E | -102.6 | 119.0 | 34.0 | 0.151 | 0.0 |
HOH |
8.391 |
HA |
O |
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| 6u26 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:480 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:480 | B:510 | 62.0 | 0.276 | E | -115.7 | 120.2 | NA | NA | NA | |||||||||||||
| 6u2n | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:480 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:480 | B:510 | 49.0 | 0.218 | E | -117.7 | 122.3 | 49.0 | 0.218 | 0.0 |
PV7 HOH |
9.091 7.886 |
NH2 CG |
O27 O |
|||||||||
| 6u2p | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:480 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:480 | B:510 | 49.0 | 0.218 | E | -113.8 | 125.2 | 49.0 | 0.218 | 0.0 |
PUV HOH |
9.223 7.906 |
N CG |
F O |
|||||||||
| 6u36 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:480 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:480 | B:510 | 46.0 | 0.204 | E | -116.8 | 117.2 | 46.0 | 0.204 | 0.0 |
PVM |
7.812 |
NH2 |
C38 |
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| 6u38 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:480 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:480 | B:510 | 62.0 | 0.276 | E | -125.7 | 117.9 | 62.0 | 0.276 | 0.0 |
PVJ HOH |
9.271 8.329 |
N CA |
F O |
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| 6u3x | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:480 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:480 | B:510 | 57.0 | 0.253 | E | -110.1 | 131.7 | 57.0 | 0.253 | 0.0 |
HOH |
9.277 |
O |
O |
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| 2pmw | 2 | Q5SZQ2 | 100.0 | 0.0 |
X-RAY |
2007-05-08 | ARG | B:358 | B:510 | 56.0 | 0.249 | E | -128.4 | 122.6 | 56.0 | 0.249 | 0.0 |
HOH |
8.035 |
CA |
O |
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| 3p5b | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | ARG | B:358 | A:510 | 64.0 | 0.284 | E | -110.5 | 130.6 | 64.0 | 0.284 | 0.0 | ||||||
| 3p5c | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | ARG | B:358 | A:510 | 64.0 | 0.284 | E | -110.5 | 130.5 | 64.0 | 0.284 | 0.0 | ||||||
| 3bps | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2008-02-12 | ARG | B:358 | A:510 | 48.0 | 0.213 | E | -116.4 | 140.0 | 48.0 | 0.213 | 0.0 |
HOH |
6.738 |
O |
O |
||
| 3gcw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | ARG | B:358 | A:510 | 40.0 | 0.178 | E | -136.7 | 141.8 | 40.0 | 0.178 | 0.0 | ||||||
| 3gcx | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | ARG | B:358 | A:510 | 35.0 | 0.156 | E | -129.9 | 142.9 | 35.0 | 0.156 | 0.0 | ||||||
| 3sqo | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2012-05-16 | ARG | A:358 | A:510 | 64.0 | 0.284 | E | -121.9 | 129.3 | 64.0 | 0.284 | 0.0 |
HOH |
4.161 |
NH1 |
O |
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| 4ne9 | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2014-09-10 | ARG | A:358 | A:510 | 42.0 | 0.187 | E | -116.3 | 126.8 | 42.0 | 0.187 | 0.0 | ||||||
| ARG | B:358 | B:510 | 42.0 | 0.187 | E | -114.0 | 126.0 | NA | NA | NA | |||||||||||||
| 4k8r | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2013-05-08 | ARG | B:358 | B:510 | 57.0 | 0.253 | E | -108.8 | 125.2 | 57.0 | 0.253 | 0.0 |
HOH |
7.836 |
CG |
O |
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| 5vl7 | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2017-08-16 | ARG | B:358 | B:510 | 65.0 | 0.289 | E | -116.0 | 129.9 | 65.0 | 0.289 | 0.0 | ||||||
| 2qtw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2007-09-18 | ARG | B:358 | B:510 | 71.0 | 0.316 | E | -116.4 | 130.4 | 71.0 | 0.316 | 0.0 |
HOH |
3.197 |
NH2 |
O |
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| 7kev | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-24 | ARG | B:358 | B:510 | 35.0 | 0.156 | E | -133.3 | 125.8 | 35.0 | 0.156 | 0.0 | ||||||
| 7kfa | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-10 | ARG | B:358 | B:510 | 38.0 | 0.169 | E | -108.6 | 129.0 | 38.0 | 0.169 | 0.0 |
HOH |
8.924 |
O |
O |
||
| 3m0c | 2 | Q8NBP7 | 99.44 | 0.0 |
X-RAY |
2011-03-16 | ARG | B:358 | B:510 | 71.0 | 0.316 | E | -116.3 | 130.3 | 71.0 | 0.316 | 0.0 | ||||||
| 3h42 | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2009-05-05 | ARG | B:358 | B:510 | 56.0 | 0.249 | E | -110.9 | 122.8 | 56.0 | 0.249 | 0.0 |
HOH |
7.790 |
CD |
O |
||
| 5oca | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2017-09-20 | ARG | B:358 | B:510 | 51.0 | 0.227 | E | -116.9 | 124.5 | 51.0 | 0.227 | 0.0 |
HOH |
7.304 |
NH2 |
O |
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| 7anq | 1 | Q8NBP7 | 100.0 | 6e-167 |
X-RAY |
2021-10-20 | ARG | A:59 | A:510 | 46.0 | 0.204 | E | -107.5 | 127.2 | 46.0 | 0.204 | 0.0 |
HOH |
3.596 |
NE |
O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q8nbp7-f1 | 1 | Q8NBP7 | 100.0 | 0.0 | ARG | A:510 | A:510 | 37.0 | 0.164 | E | -114.8 | 119.3 | |