Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55525195 . G A CCDS603.1:NM_174936.3:c.1540Gct>Act_NP_777596.2:p.514A>T Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
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auth_asym_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 ALA A:514 NA:NA DO NA DO DO DO NA NA NA
ALA B:514 A:514 10.0 0.087 -72.7 154.0 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ALA A:514 A:514 13.0 0.113 -102.9 174.1 13.0 0.113 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 ALA A:514 A:514 15.0 0.13 -110.1 167.6 15.0 0.13 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ALA A:514 A:514 15.0 0.13 -106.4 167.7 15.0 0.13 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ALA A:484 NA:NA DO NA DO DO DO NA NA NA
ALA B:484 B:514 5.0 0.043 -100.4 164.2 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ALA A:484 NA:NA DO NA DO DO DO NA NA NA
ALA B:484 B:514 11.0 0.096 -118.4 172.4 11.0 0.096 0.0 HOH
 3.252
 C
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ALA A:484 NA:NA DO NA DO DO DO NA NA NA
ALA B:484 B:514 6.0 0.052 -117.0 166.7 6.0 0.052 0.0 HOH
 7.907
 N
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ALA A:484 NA:NA DO NA DO DO DO NA NA NA
ALA B:484 B:514 7.0 0.061 -95.2 161.2 7.0 0.061 0.0
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ALA A:484 NA:NA DO NA DO DO DO NA NA NA
ALA B:484 B:514 8.0 0.07 -91.0 167.2 8.0 0.07 0.0
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ALA A:484 NA:NA DO NA DO DO DO NA NA NA
ALA B:484 B:514 12.0 0.104 -100.4 172.9 12.0 0.104 0.0
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 ALA B:362 B:514 4.0 0.035 -73.2 139.9 4.0 0.035 0.0 HOH
 4.949
 N
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ALA B:362 A:514 5.0 0.043 -85.0 167.1 5.0 0.043 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ALA B:362 A:514 4.0 0.035 -85.0 167.0 4.0 0.035 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 ALA B:362 A:514 14.0 0.122 -71.9 172.1 14.0 0.122 0.0 HOH
 5.520
 O
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ALA B:362 A:514 11.0 0.096 -73.8 -169.7 11.0 0.096 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ALA B:362 A:514 13.0 0.113 -80.6 -172.8 13.0 0.113 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 ALA A:362 A:514 6.0 0.052 -98.3 173.8 6.0 0.052 0.0 HOH
 5.004
 N
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 ALA A:362 A:514 10.0 0.087 -78.8 158.4 10.0 0.087 0.0
ALA B:362 B:514 10.0 0.087 -79.7 159.6 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 ALA B:362 B:514 7.0 0.061 -71.3 144.3 7.0 0.061 0.0
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 ALA B:362 NA:NA DO NA DO DO DO NA NA NA
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 ALA B:362 B:514 12.0 0.104 -91.3 159.4 12.0 0.104 0.0 HOH
 5.373
 N
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 ALA B:362 B:514 3.0 0.026 -74.1 360.0 3.0 0.026 0.0
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 ALA B:362 B:514 3.0 0.026 -90.3 360.0 3.0 0.026 0.0
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 ALA B:362 B:514 13.0 0.113 -91.4 159.4 13.0 0.113 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 ALA B:362 B:514 3.0 0.026 -77.6 156.7 3.0 0.026 0.0
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 ALA B:362 B:514 7.0 0.061 -67.0 -138.3 7.0 0.061 0.0 HOH
 5.297
 O
 O
7anq 1 Q8NBP7 100.0 6e-167 X-RAY
 2021-10-20 ALA A:63 A:514 1.0 0.009 -100.0 157.4 1.0 0.009 0.0 HOH
 3.452
 CB
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 ALA A:514 A:514 11.0 0.096 -113.1 173.8