Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr1 | 55525219 | . | G | A | CCDS603.1:NM_174936.3:c.1564Gcc>Acc_NP_777596.2:p.522A>T | Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 2p4e | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2007-04-10 | ALA | A:522 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | B:522 | A:522 | 0.0 | 0.0 | E | -89.5 | 138.4 | NA | NA | NA | |||||||||||||
| 6u2f | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | ALA | A:522 | A:522 | 0.0 | 0.0 | E | -100.3 | 129.6 | 0.0 | 0.0 | 0.0 | ||||||
| 5vlp | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2017-08-16 | ALA | A:522 | A:522 | 0.0 | 0.0 | E | -102.1 | 127.6 | 0.0 | 0.0 | 0.0 | ||||||
| 6u3i | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | ALA | A:522 | A:522 | 0.0 | 0.0 | E | -110.0 | 132.9 | 0.0 | 0.0 | 0.0 |
HOH |
6.200 |
HB3 |
O |
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| 6u26 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ALA | A:492 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | B:492 | B:522 | 0.0 | 0.0 | E | -102.7 | 136.5 | NA | NA | NA | |||||||||||||
| 6u2n | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ALA | A:492 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | B:492 | B:522 | 0.0 | 0.0 | E | -99.7 | 132.8 | 0.0 | 0.0 | 0.0 |
PV7 HOH |
7.103 6.332 |
O CB |
C25 O |
|||||||||
| 6u2p | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ALA | A:492 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | B:492 | B:522 | 0.0 | 0.0 | E | -100.3 | 130.6 | 0.0 | 0.0 | 0.0 |
EDO PUV HOH |
7.149 6.551 6.420 |
C O CB |
C2 F O |
|||||||||
| 6u36 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ALA | A:492 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | B:492 | B:522 | 0.0 | 0.0 | E | -105.1 | 130.0 | 0.0 | 0.0 | 0.0 |
PVM |
6.547 |
O |
F |
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| 6u38 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ALA | A:492 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | B:492 | B:522 | 0.0 | 0.0 | E | -103.1 | 124.2 | 0.0 | 0.0 | 0.0 |
PVJ HOH |
6.302 6.143 |
O CB |
F O |
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| 6u3x | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ALA | A:492 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | B:492 | B:522 | 0.0 | 0.0 | E | -107.1 | 113.6 | 0.0 | 0.0 | 0.0 |
PVV HOH |
7.340 7.382 |
O C |
C15 O |
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| 2pmw | 2 | Q5SZQ2 | 100.0 | 0.0 |
X-RAY |
2007-05-08 | ALA | B:370 | B:522 | 0.0 | 0.0 | E | -95.1 | 140.0 | 0.0 | 0.0 | 0.0 |
HOH |
6.277 |
CB |
O |
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| 3p5b | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | ALA | B:370 | A:522 | 0.0 | 0.0 | E | -90.8 | 123.7 | 0.0 | 0.0 | 0.0 | ||||||
| 3p5c | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | ALA | B:370 | A:522 | 0.0 | 0.0 | E | -90.8 | 123.7 | 0.0 | 0.0 | 0.0 | ||||||
| 3bps | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2008-02-12 | ALA | B:370 | A:522 | 0.0 | 0.0 | E | -94.0 | 139.6 | 0.0 | 0.0 | 0.0 |
HOH |
6.750 |
O |
O |
||
| 3gcw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | ALA | B:370 | A:522 | 0.0 | 0.0 | E | -93.6 | 140.5 | 0.0 | 0.0 | 0.0 | ||||||
| 3gcx | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | ALA | B:370 | A:522 | 0.0 | 0.0 | E | -88.1 | 140.6 | 0.0 | 0.0 | 0.0 | ||||||
| 3sqo | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2012-05-16 | ALA | A:370 | A:522 | 0.0 | 0.0 | E | -104.0 | 130.9 | 0.0 | 0.0 | 0.0 |
HOH |
8.073 |
CB |
O |
||
| 4ne9 | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2014-09-10 | ALA | A:370 | A:522 | 0.0 | 0.0 | E | -96.3 | 134.7 | 0.0 | 0.0 | 0.0 | ||||||
| ALA | B:370 | B:522 | 0.0 | 0.0 | E | -97.0 | 133.8 | NA | NA | NA | |||||||||||||
| 4k8r | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2013-05-08 | ALA | B:370 | B:522 | 0.0 | 0.0 | E | -105.3 | 129.0 | 0.0 | 0.0 | 0.0 |
HOH |
3.029 |
N |
O |
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| 5vl7 | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2017-08-16 | ALA | B:370 | B:522 | 0.0 | 0.0 | E | -81.4 | 121.6 | 0.0 | 0.0 | 0.0 | ||||||
| 2qtw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2007-09-18 | ALA | B:370 | B:522 | 0.0 | 0.0 | E | -97.2 | 139.1 | 0.0 | 0.0 | 0.0 |
HOH |
6.356 |
O |
O |
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| 7kev | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-24 | ALA | B:370 | B:522 | 0.0 | 0.0 | E | -105.3 | 122.4 | 0.0 | 0.0 | 0.0 | ||||||
| 7kfa | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-10 | ALA | B:370 | B:522 | 0.0 | 0.0 | E | -94.2 | 136.4 | 0.0 | 0.0 | 0.0 |
HOH |
7.308 |
O |
O |
||
| 3m0c | 2 | Q8NBP7 | 99.44 | 0.0 |
X-RAY |
2011-03-16 | ALA | B:370 | B:522 | 0.0 | 0.0 | E | -97.2 | 139.0 | 0.0 | 0.0 | 0.0 | ||||||
| 3h42 | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2009-05-05 | ALA | B:370 | B:522 | 0.0 | 0.0 | E | -96.1 | 140.1 | 0.0 | 0.0 | 0.0 |
HOH |
6.460 |
CB |
O |
||
| 5oca | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2017-09-20 | ALA | B:370 | B:522 | 0.0 | 0.0 | E | -93.2 | 139.1 | 0.0 | 0.0 | 0.0 |
HOH |
7.104 |
O |
O |
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| 7anq | 1 | Q8NBP7 | 100.0 | 6e-167 |
X-RAY |
2021-10-20 | ALA | A:71 | A:522 | 0.0 | 0.0 | E | -90.1 | 137.9 | 0.0 | 0.0 | 0.0 |
SO4 HOH |
9.960 6.402 |
O CB |
O2 O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q8nbp7-f1 | 1 | Q8NBP7 | 100.0 | 0.0 | ALA | A:522 | A:522 | 0.0 | 0.0 | E | -100.6 | 133.8 | |