Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr1 | 55525261 | . | G | A | CCDS603.1:NM_174936.3:c.1606Gtc>Atc_NP_777596.2:p.536V>I | Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 2p4e | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2007-04-10 | VAL | A:536 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:536 | A:536 | 39.0 | 0.252 | E | -110.9 | 140.2 | NA | NA | NA | |||||||||||||
| 6u2f | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | VAL | A:536 | A:536 | 34.0 | 0.219 | E | -101.1 | 135.9 | 20.0 | 0.129 | 0.09 |
D:A0A0U5BC76:0.09 |
HOH |
6.590 |
H |
O |
|
| 5vlp | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2017-08-16 | VAL | A:536 | A:536 | 31.0 | 0.2 | E | -103.0 | 119.0 | 18.0 | 0.116 | 0.084 |
C:A0A0U5BC76:0.084 |
HOH |
7.176 |
N |
O |
|
| 6u3i | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | VAL | A:536 | A:536 | 33.0 | 0.213 | E | -100.4 | 131.3 | 19.0 | 0.123 | 0.09 |
D:A0A0U5BC76:0.09 |
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| 6u26 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:506 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:506 | B:536 | 35.0 | 0.226 | E | -113.2 | 133.1 | NA | NA | NA | |||||||||||||
| 6u2n | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:506 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:506 | B:536 | 40.0 | 0.258 | E | -110.8 | 138.7 | 40.0 | 0.258 | 0.0 |
HOH |
3.792 |
CG1 |
O |
|||||||||
| 6u2p | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:506 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:506 | B:536 | 40.0 | 0.258 | E | -108.2 | 137.2 | 40.0 | 0.258 | 0.0 | |||||||||||||
| 6u36 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:506 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:506 | B:536 | 36.0 | 0.232 | E | -99.3 | 133.6 | 36.0 | 0.232 | 0.0 | |||||||||||||
| 6u38 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:506 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:506 | B:536 | 38.0 | 0.245 | E | -97.9 | 132.8 | 38.0 | 0.245 | 0.0 |
HOH |
6.699 |
N |
O |
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| 6u3x | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:506 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:506 | B:536 | 38.0 | 0.245 | E | -111.8 | 126.7 | 38.0 | 0.245 | 0.0 |
HOH |
8.417 |
CG2 |
O |
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| 2pmw | 2 | Q5SZQ2 | 100.0 | 0.0 |
X-RAY |
2007-05-08 | VAL | B:384 | B:536 | 38.0 | 0.245 | E | -114.6 | 140.1 | 38.0 | 0.245 | 0.0 |
HOH |
7.690 |
CG2 |
O |
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| 3p5b | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | VAL | B:384 | A:536 | 29.0 | 0.187 | E | -82.2 | 121.4 | 29.0 | 0.187 | 0.0 | ||||||
| 3p5c | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | VAL | B:384 | A:536 | 28.0 | 0.181 | E | -82.2 | 121.4 | 28.0 | 0.181 | 0.0 | ||||||
| 3bps | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2008-02-12 | VAL | B:384 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 3gcw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | VAL | B:384 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 3gcx | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | VAL | B:384 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 3sqo | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2012-05-16 | VAL | A:384 | A:536 | 41.0 | 0.265 | E | -115.3 | 138.0 | 41.0 | 0.265 | 0.0 |
HOH |
7.862 |
O |
O |
||
| 4ne9 | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2014-09-10 | VAL | A:384 | A:536 | 42.0 | 0.271 | E | -106.7 | 134.7 | 42.0 | 0.271 | 0.0 | ||||||
| VAL | B:384 | B:536 | 42.0 | 0.271 | E | -102.0 | 133.6 | NA | NA | NA | |||||||||||||
| 4k8r | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2013-05-08 | VAL | B:384 | B:536 | 41.0 | 0.265 | E | -93.5 | 121.7 | 41.0 | 0.265 | 0.0 |
HOH |
4.252 |
O |
O |
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| 5vl7 | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2017-08-16 | VAL | B:384 | B:536 | 36.0 | 0.232 | E | -114.4 | 118.8 | 36.0 | 0.232 | 0.0 | ||||||
| 2qtw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2007-09-18 | VAL | B:384 | B:536 | 38.0 | 0.245 | E | -119.6 | 137.6 | 38.0 | 0.245 | 0.0 |
HOH |
4.173 |
CG2 |
O |
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| 7kev | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-24 | VAL | B:384 | B:536 | 39.0 | 0.252 | E | -97.2 | 137.2 | 39.0 | 0.252 | 0.0 | ||||||
| 7kfa | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-10 | VAL | B:384 | B:536 | 37.0 | 0.239 | E | -115.9 | 138.2 | 37.0 | 0.239 | 0.0 | ||||||
| 3m0c | 2 | Q8NBP7 | 99.44 | 0.0 |
X-RAY |
2011-03-16 | VAL | B:384 | B:536 | 38.0 | 0.245 | E | -119.5 | 137.6 | 38.0 | 0.245 | 0.0 | ||||||
| 3h42 | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2009-05-05 | VAL | B:384 | B:536 | 36.0 | 0.232 | E | -111.1 | 141.4 | 36.0 | 0.232 | 0.0 |
HOH |
7.810 |
CG1 |
O |
||
| 5oca | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2017-09-20 | VAL | B:384 | B:536 | 43.0 | 0.277 | E | -114.5 | 142.5 | 43.0 | 0.277 | 0.0 |
HOH |
6.012 |
N |
O |
||
| 7anq | 1 | Q8NBP7 | 100.0 | 6e-167 |
X-RAY |
2021-10-20 | VAL | A:85 | A:536 | 44.0 | 0.284 | E | -112.6 | 131.4 | 44.0 | 0.284 | 0.0 |
HOH |
3.144 |
N |
O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q8nbp7-f1 | 1 | Q8NBP7 | 100.0 | 0.0 | VAL | A:536 | A:536 | 32.0 | 0.206 | E | -107.0 | 114.0 | |