Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55525301 . G A CCDS603.1:NM_174936.3:c.1646cGt>cAt_NP_777596.2:p.549R>H Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 ARG A:549 NA:NA DO NA DO DO DO NA NA NA
ARG B:549 A:549 107.0 0.476 E -130.6 141.3 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ARG A:549 A:549 107.0 0.476 -71.6 117.8 40.0 0.178 0.298 C:Q569X1:0.298
 CA
 8.211
 HH12
 CA
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 ARG A:549 A:549 112.0 0.498 -75.3 112.2 39.0 0.173 0.325 B:None:0.324
 HOH
 9.872
 NH2
 O
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ARG A:549 A:549 108.0 0.48 -76.2 115.7 43.0 0.191 0.289 C:None:0.289
 CA
HOH
 7.796
8.880
 HH12
HH22
 CA
O
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:519 NA:NA DO NA DO DO DO NA NA NA
ARG B:519 B:549 158.0 0.702 E -132.1 152.5 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:519 NA:NA DO NA DO DO DO NA NA NA
ARG B:519 B:549 117.0 0.52 E -136.8 146.2 117.0 0.52 0.0 HOH
 7.540
 CG
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:519 NA:NA DO NA DO DO DO NA NA NA
ARG B:519 B:549 89.0 0.396 E -135.0 151.5 89.0 0.396 0.0 HOH
 5.099
 O
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:519 NA:NA DO NA DO DO DO NA NA NA
ARG B:519 B:549 66.0 NA E -145.0 146.0 66.0 NA NA
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:519 NA:NA DO NA DO DO DO NA NA NA
ARG B:519 B:549 138.0 0.613 E -126.6 144.4 138.0 0.613 0.0
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:519 NA:NA DO NA DO DO DO NA NA NA
ARG B:519 B:549 93.0 0.413 E -130.9 149.4 93.0 0.413 0.0
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 ARG B:397 B:549 126.0 0.56 E -126.8 152.3 126.0 0.56 0.0 HOH
 3.074
 N
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ARG B:397 A:549 133.0 0.591 E -140.6 142.5 133.0 0.591 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ARG B:397 A:549 133.0 0.591 E -140.5 142.5 133.0 0.591 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 ARG B:397 NA:NA DO NA DO DO DO NA NA NA
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ARG B:397 NA:NA DO NA DO DO DO NA NA NA
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ARG B:397 NA:NA DO NA DO DO DO NA NA NA
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 ARG A:397 A:549 105.0 0.467 E -133.4 141.2 105.0 0.467 0.0 HOH
 2.979
 N
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 ARG A:397 A:549 114.0 0.507 E -129.9 140.5 114.0 0.507 0.0
ARG B:397 B:549 113.0 0.502 E -129.4 140.4 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 ARG B:397 B:549 86.0 0.382 E -128.7 156.2 86.0 0.382 0.0 HOH
 3.309
 NH1
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 ARG B:397 B:549 103.0 0.458 E -120.9 153.0 103.0 0.458 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 ARG B:397 B:549 99.0 0.44 E -140.4 147.9 99.0 0.44 0.0 HOH
 3.121
 N
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 ARG B:397 B:549 104.0 0.462 -86.8 157.5 104.0 0.462 0.0
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 ARG B:397 B:549 121.0 0.538 -93.0 -173.1 121.0 0.538 0.0 HOH
 3.148
 CA
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 ARG B:397 B:549 95.0 0.422 E -140.3 147.9 95.0 0.422 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 ARG B:397 B:549 88.0 0.391 E -136.6 142.5 88.0 0.391 0.0 HOH
 9.596
 CA
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 ARG B:397 B:549 132.0 0.587 E -123.6 147.4 132.0 0.587 0.0 HOH
 7.385
 NH1
 O
7anq 1 Q8NBP7 100.0 6e-167 X-RAY
 2021-10-20 ARG A:98 A:549 138.0 0.613 E -126.1 139.8 138.0 0.613 0.0 HOH
 9.077
 N
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 ARG A:549 A:549 153.0 0.68 -81.6 134.0