Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55525313 . A C CCDS603.1:NM_174936.3:c.1658cAc>cCc_NP_777596.2:p.553H>P Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 HIS A:553 NA:NA DO NA DO DO DO NA NA NA
HIS B:553 A:553 130.0 0.667 -62.6 -37.8 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 HIS A:553 A:553 125.0 0.641 -51.7 -20.8 33.0 0.169 0.472 D:A0A0U5BC76:0.303
C:Q569X1:0.256
 CA
 4.151
 C
 CA
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 HIS A:553 A:553 124.0 0.636 -58.6 -12.4 33.0 0.169 0.467 B:None:0.251
C:A0A0U5BC76:0.303
 HOH
 2.946
 ND1
 O
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 HIS A:553 A:553 122.0 0.626 -58.3 -7.6 33.0 0.169 0.457 D:A0A0U5BC76:0.297
C:None:0.246
 CA
HOH
 4.373
2.380
 C
HD1
 CA
O
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:523 NA:NA DO NA DO DO DO NA NA NA
HIS B:523 B:553 140.0 0.718 -67.7 -46.5 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:523 NA:NA DO NA DO DO DO NA NA NA
HIS B:523 B:553 91.0 NA -107.1 78.1 91.0 NA NA
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:523 NA:NA DO NA DO DO DO NA NA NA
HIS B:523 B:553 122.0 0.626 -63.4 -37.0 122.0 0.626 0.0
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:523 NA:NA DO NA DO DO DO NA NA NA
HIS B:523 B:553 133.0 0.682 -109.5 -18.7 133.0 0.682 0.0
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:523 NA:NA DO NA DO DO DO NA NA NA
HIS B:523 B:553 124.0 0.636 -112.5 -19.9 124.0 0.636 0.0 HOH
 8.799
 O
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:523 NA:NA DO NA DO DO DO NA NA NA
HIS B:523 B:553 131.0 0.672 -69.4 -46.7 131.0 0.672 0.0
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 HIS B:401 B:553 120.0 0.615 -79.2 -33.5 120.0 0.615 0.0
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 HIS B:401 A:553 126.0 0.646 -73.5 -25.0 126.0 0.646 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 HIS B:401 A:553 127.0 0.651 -73.5 -25.0 127.0 0.651 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 HIS B:401 NA:NA DO NA DO DO DO NA NA NA
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 HIS B:401 NA:NA DO NA DO DO DO NA NA NA
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 HIS B:401 NA:NA DO NA DO DO DO NA NA NA
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 HIS A:401 A:553 144.0 0.738 -97.3 -21.7 144.0 0.738 0.0 HOH
 3.195
 CB
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 HIS A:401 A:553 123.0 0.631 -61.7 -37.1 123.0 0.631 0.0 NAG
FUC
 9.889
8.910
 CE1
CE1
 C6
C1
HIS B:401 B:553 117.0 0.6 -60.9 -32.9 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 HIS B:401 B:553 124.0 0.636 -75.9 -35.7 124.0 0.636 0.0 HOH
 7.613
 ND1
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 HIS B:401 B:553 110.0 0.564 -49.8 -27.1 110.0 0.564 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 HIS B:401 B:553 121.0 0.621 -81.7 -28.5 121.0 0.621 0.0 HOH
 8.608
 CE1
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 HIS B:401 B:553 127.0 0.651 -69.2 -21.8 127.0 0.651 0.0
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 HIS B:401 B:553 134.0 0.687 -91.4 -19.6 134.0 0.687 0.0 HOH
 2.708
 CE1
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 HIS B:401 B:553 121.0 0.621 -81.8 -28.4 121.0 0.621 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 HIS B:401 B:553 139.0 0.713 -65.7 -48.3 139.0 0.713 0.0 HOH
 4.372
 O
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 HIS B:401 B:553 137.0 0.703 -69.0 -44.2 137.0 0.703 0.0 HOH
 2.605
 O
 O
7anq 1 Q8NBP7 100.0 6e-167 X-RAY
 2021-10-20 HIS A:102 A:553 125.0 0.641 -80.9 -34.0 125.0 0.641 0.0 FUC
HOH
 8.031
7.776
 C
ND1
 C6
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 HIS A:553 A:553 126.0 0.646 -95.6 -13.9