Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr1 | 55525315 | . | C | A | CCDS603.1:NM_174936.3:c.1660Caa>Aaa_NP_777596.2:p.554Q>K | Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 2p4e | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2007-04-10 | GLN | A:554 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLN | B:554 | A:554 | 85.0 | 0.472 | S | -75.6 | 177.8 | NA | NA | NA | |||||||||||||
| 6u2f | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | GLN | A:554 | A:554 | 36.0 | 0.2 | S | -70.7 | 132.1 | 2.0 | 0.011 | 0.189 |
D:A0A0U5BC76:0.183 |
CA |
2.555 |
O |
CA |
|
| 5vlp | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2017-08-16 | GLN | A:554 | A:554 | 37.0 | 0.206 | S | -81.1 | 139.6 | 3.0 | 0.017 | 0.189 |
C:A0A0U5BC76:0.189 |
HOH |
5.160 |
N |
O |
|
| 6u3i | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | GLN | A:554 | A:554 | 38.0 | 0.211 | S | -86.9 | 132.9 | 2.0 | 0.011 | 0.2 |
D:A0A0U5BC76:0.194 |
CA HOH |
2.888 4.848 |
O HA |
CA O |
|
| 6u26 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | GLN | A:524 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLN | B:524 | B:554 | 40.0 | NA | S | -54.3 | 138.7 | NA | NA | NA | |||||||||||||
| 6u2n | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | GLN | A:524 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLN | B:524 | B:554 | 132.0 | 0.733 | S | -157.0 | 135.0 | 132.0 | 0.733 | 0.0 | |||||||||||||
| 6u2p | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | GLN | A:524 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLN | B:524 | B:554 | 111.0 | 0.617 | S | -65.2 | 145.3 | 111.0 | 0.617 | 0.0 | |||||||||||||
| 6u36 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | GLN | A:524 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLN | B:524 | B:554 | 52.0 | 0.289 | S | -62.9 | 155.0 | 52.0 | 0.289 | 0.0 | |||||||||||||
| 6u38 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | GLN | A:524 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLN | B:524 | B:554 | 60.0 | 0.333 | S | -63.4 | 158.0 | 60.0 | 0.333 | 0.0 |
HOH |
5.302 |
OE1 |
O |
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| 6u3x | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | GLN | A:524 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLN | B:524 | B:554 | 115.0 | 0.639 | S | -65.9 | 148.9 | 115.0 | 0.639 | 0.0 | |||||||||||||
| 2pmw | 2 | Q5SZQ2 | 100.0 | 0.0 |
X-RAY |
2007-05-08 | GLN | B:402 | B:554 | 73.0 | 0.406 | S | -81.1 | 155.3 | 73.0 | 0.406 | 0.0 | ||||||
| 3p5b | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | GLN | B:402 | A:554 | 96.0 | 0.533 | S | -77.1 | 140.8 | 96.0 | 0.533 | 0.0 | ||||||
| 3p5c | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | GLN | B:402 | A:554 | 94.0 | 0.522 | S | -77.2 | 140.9 | 94.0 | 0.522 | 0.0 | ||||||
| 3bps | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2008-02-12 | GLN | B:402 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 3gcw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | GLN | B:402 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 3gcx | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | GLN | B:402 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 3sqo | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2012-05-16 | GLN | A:402 | A:554 | 102.0 | 0.567 | S | -58.4 | 159.5 | 102.0 | 0.567 | 0.0 |
HOH |
3.026 |
N |
O |
||
| 4ne9 | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2014-09-10 | GLN | A:402 | A:554 | 87.0 | 0.483 | S | -75.7 | 159.9 | 87.0 | 0.483 | 0.0 |
NAG FUC |
5.311 3.898 |
OE1 OE1 |
O6 O5 |
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| GLN | B:402 | B:554 | 80.0 | 0.444 | S | -72.7 | 146.7 | NA | NA | NA | |||||||||||||
| 4k8r | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2013-05-08 | GLN | B:402 | B:554 | 97.0 | 0.539 | S | -65.0 | 134.2 | 97.0 | 0.539 | 0.0 |
HOH |
9.174 |
OE1 |
O |
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| 5vl7 | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2017-08-16 | GLN | B:402 | B:554 | 79.0 | 0.439 | S | -78.9 | 159.0 | 79.0 | 0.439 | 0.0 | ||||||
| 2qtw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2007-09-18 | GLN | B:402 | B:554 | 85.0 | 0.472 | S | -61.3 | 139.3 | 85.0 | 0.472 | 0.0 |
NAG HOH |
9.293 4.802 |
NE2 OE1 |
O7 O |
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| 7kev | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-24 | GLN | B:402 | B:554 | 74.0 | 0.411 | S | -56.9 | 117.1 | 74.0 | 0.411 | 0.0 | ||||||
| 7kfa | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-10 | GLN | B:402 | B:554 | 94.0 | 0.522 | S | -55.6 | 159.6 | 94.0 | 0.522 | 0.0 |
HOH |
6.190 |
N |
O |
||
| 3m0c | 2 | Q8NBP7 | 99.44 | 0.0 |
X-RAY |
2011-03-16 | GLN | B:402 | B:554 | 85.0 | 0.472 | S | -61.2 | 139.4 | 85.0 | 0.472 | 0.0 | ||||||
| 3h42 | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2009-05-05 | GLN | B:402 | B:554 | 91.0 | 0.506 | S | -58.2 | 144.2 | 91.0 | 0.506 | 0.0 |
HOH |
3.388 |
CA |
O |
||
| 5oca | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2017-09-20 | GLN | B:402 | B:554 | 95.0 | 0.528 | S | -65.0 | 147.0 | 95.0 | 0.528 | 0.0 |
HOH |
2.589 |
O |
O |
||
| 7anq | 1 | Q8NBP7 | 100.0 | 6e-167 |
X-RAY |
2021-10-20 | GLN | A:103 | A:554 | 106.0 | 0.589 | S | -79.2 | 139.0 | 106.0 | 0.589 | 0.0 |
NAG NAG FUC HOH |
4.062 7.423 3.288 7.826 |
NE2 NE2 NE2 O |
O6 C1 O5 O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q8nbp7-f1 | 1 | Q8NBP7 | 100.0 | 0.0 | GLN | A:554 | A:554 | 74.0 | 0.411 | S | -77.6 | 134.9 | |