Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr1 | 55527131 | . | G | A | CCDS603.1:NM_174936.3:c.1765Gtg>Atg_NP_777596.2:p.589V>M | Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 2p4e | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2007-04-10 | VAL | A:589 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:589 | A:589 | 72.0 | 0.465 | E | -126.6 | 135.8 | NA | NA | NA | |||||||||||||
| 6u2f | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | VAL | A:589 | A:589 | 23.0 | 0.148 | -97.7 | 142.7 | 23.0 | 0.148 | 0.0 | |||||||
| 5vlp | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2017-08-16 | VAL | A:589 | A:589 | 22.0 | 0.142 | -86.0 | 133.3 | 22.0 | 0.142 | 0.0 | |||||||
| 6u3i | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | VAL | A:589 | A:589 | 18.0 | 0.116 | -110.5 | 139.2 | 18.0 | 0.116 | 0.0 |
HOH |
2.648 |
H |
O |
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| 6u26 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:559 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:559 | B:589 | 57.0 | 0.368 | E | -129.3 | 131.1 | NA | NA | NA | |||||||||||||
| 6u2n | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:559 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:559 | B:589 | 49.0 | 0.316 | E | -123.5 | 130.1 | 49.0 | 0.316 | 0.0 |
HOH |
2.822 |
N |
O |
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| 6u2p | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:559 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:559 | B:589 | 44.0 | 0.284 | E | -123.9 | 128.7 | 44.0 | 0.284 | 0.0 |
HOH |
5.234 |
O |
O |
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| 6u36 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:559 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:559 | B:589 | 79.0 | 0.51 | E | -124.2 | 142.3 | 79.0 | 0.51 | 0.0 | |||||||||||||
| 6u38 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:559 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:559 | B:589 | 60.0 | 0.387 | E | -123.3 | 127.2 | 60.0 | 0.387 | 0.0 |
HOH |
8.332 |
O |
O |
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| 6u3x | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:559 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:559 | B:589 | 52.0 | 0.335 | E | -114.6 | 132.6 | 52.0 | 0.335 | 0.0 | |||||||||||||
| 2pmw | 2 | Q5SZQ2 | 100.0 | 0.0 |
X-RAY |
2007-05-08 | VAL | B:437 | B:589 | 61.0 | 0.394 | E | -120.4 | 140.1 | 61.0 | 0.394 | 0.0 |
HOH |
4.711 |
O |
O |
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| 3p5b | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | VAL | B:437 | A:589 | 58.0 | 0.374 | E | -89.4 | 119.3 | 58.0 | 0.374 | 0.0 | ||||||
| 3p5c | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | VAL | B:437 | A:589 | 58.0 | 0.374 | E | -89.4 | 119.3 | 58.0 | 0.374 | 0.0 | ||||||
| 3bps | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2008-02-12 | VAL | B:437 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 3gcw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | VAL | B:437 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 3gcx | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | VAL | B:437 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 3sqo | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2012-05-16 | VAL | A:437 | A:589 | 68.0 | 0.439 | E | -102.8 | 133.4 | 68.0 | 0.439 | 0.0 |
HOH |
8.150 |
CA |
O |
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| 4ne9 | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2014-09-10 | VAL | A:437 | A:589 | 69.0 | 0.445 | E | -131.1 | 125.1 | 69.0 | 0.445 | 0.0 | ||||||
| VAL | B:437 | B:589 | 70.0 | 0.452 | E | -131.7 | 124.1 | NA | NA | NA | |||||||||||||
| 4k8r | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2013-05-08 | VAL | B:437 | B:589 | 56.0 | 0.361 | E | -124.1 | 123.5 | 56.0 | 0.361 | 0.0 |
HOH |
3.188 |
O |
O |
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| 5vl7 | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2017-08-16 | VAL | B:437 | B:589 | 52.0 | 0.335 | E | -121.5 | 116.4 | 52.0 | 0.335 | 0.0 | ||||||
| 2qtw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2007-09-18 | VAL | B:437 | B:589 | 53.0 | 0.342 | E | -128.3 | 128.7 | 53.0 | 0.342 | 0.0 |
HOH |
3.034 |
N |
O |
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| 7kev | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-24 | VAL | B:437 | B:589 | 70.0 | 0.452 | -105.4 | 143.7 | 70.0 | 0.452 | 0.0 | |||||||
| 7kfa | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-10 | VAL | B:437 | B:589 | 81.0 | 0.523 | -102.2 | 153.5 | 81.0 | 0.523 | 0.0 |
HOH |
4.057 |
CG1 |
O |
|||
| 3m0c | 2 | Q8NBP7 | 99.44 | 0.0 |
X-RAY |
2011-03-16 | VAL | B:437 | B:589 | 52.0 | 0.335 | E | -128.2 | 128.7 | 52.0 | 0.335 | 0.0 | ||||||
| 3h42 | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2009-05-05 | VAL | B:437 | B:589 | 59.0 | 0.381 | E | -123.5 | 122.1 | 59.0 | 0.381 | 0.0 |
HOH |
3.546 |
O |
O |
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| 5oca | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2017-09-20 | VAL | B:437 | B:589 | 70.0 | 0.452 | E | -123.6 | 134.3 | 70.0 | 0.452 | 0.0 |
HOH |
3.008 |
N |
O |
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| 7anq | 1 | Q8NBP7 | 100.0 | 6e-167 |
X-RAY |
2021-10-20 | VAL | A:138 | A:589 | 44.0 | 0.284 | E | -124.2 | 123.5 | 44.0 | 0.284 | 0.0 |
HOH |
4.148 |
O |
O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q8nbp7-f1 | 1 | Q8NBP7 | 100.0 | 0.0 | VAL | A:589 | A:589 | 28.0 | 0.181 | -107.6 | 142.9 | ||