Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55527139 . C A CCDS603.1:NM_174936.3:c.1773caC>caA_NP_777596.2:p.591H>Q Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 HIS A:591 NA:NA DO NA DO DO DO NA NA NA
HIS B:591 A:591 54.0 0.277 -61.7 145.0 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 HIS A:591 A:591 25.0 0.128 B -85.5 150.9 25.0 0.128 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 HIS A:591 A:591 42.0 0.215 B -84.0 148.8 42.0 0.215 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 HIS A:591 A:591 26.0 0.133 B -88.0 149.7 26.0 0.133 0.0 HOH
 9.392
 H
 O
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:561 NA:NA DO NA DO DO DO NA NA NA
HIS B:561 B:591 100.0 0.513 -62.8 148.5 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:561 NA:NA DO NA DO DO DO NA NA NA
HIS B:561 B:591 53.0 NA -62.5 149.8 53.0 NA NA HOH
 9.061
 N
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:561 NA:NA DO NA DO DO DO NA NA NA
HIS B:561 B:591 69.0 0.354 -67.5 150.0 69.0 0.354 0.0 HOH
 2.952
 N
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:561 NA:NA DO NA DO DO DO NA NA NA
HIS B:561 B:591 60.0 0.308 -73.2 146.5 60.0 0.308 0.0
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:561 NA:NA DO NA DO DO DO NA NA NA
HIS B:561 B:591 36.0 0.185 -72.0 146.9 36.0 0.185 0.0
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 HIS A:561 NA:NA DO NA DO DO DO NA NA NA
HIS B:561 B:591 66.0 0.338 -83.8 143.2 66.0 0.338 0.0
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 HIS B:439 B:591 37.0 0.19 -57.8 145.7 37.0 0.19 0.0 HOH
 3.191
 N
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 HIS B:439 A:591 12.0 0.062 -70.6 153.5 12.0 0.062 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 HIS B:439 A:591 14.0 0.072 -70.5 153.4 14.0 0.072 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 HIS B:439 NA:NA DO NA DO DO DO NA NA NA
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 HIS B:439 NA:NA DO NA DO DO DO NA NA NA
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 HIS B:439 NA:NA DO NA DO DO DO NA NA NA
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 HIS A:439 A:591 82.0 0.421 -65.5 147.8 82.0 0.421 0.0 HOH
 7.836
 O
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 HIS A:439 A:591 40.0 0.205 -64.6 144.0 40.0 0.205 0.0
HIS B:439 B:591 39.0 0.2 -64.2 143.1 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 HIS B:439 B:591 42.0 0.215 -67.6 151.8 42.0 0.215 0.0 HOH
 6.026
 N
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 HIS B:439 B:591 91.0 0.467 -69.2 146.5 91.0 0.467 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 HIS B:439 B:591 64.0 0.328 -61.8 148.9 64.0 0.328 0.0 HOH
 2.833
 N
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 HIS B:439 B:591 85.0 0.436 -116.9 360.0 85.0 0.436 0.0
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 HIS B:439 B:591 93.0 0.477 -90.8 360.0 93.0 0.477 0.0 HOH
 6.430
 N
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 HIS B:439 B:591 61.0 0.313 -61.7 149.1 61.0 0.313 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 HIS B:439 B:591 35.0 0.179 -59.0 153.9 35.0 0.179 0.0 HOH
 7.060
 N
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 HIS B:439 B:591 29.0 0.149 -53.2 156.2 29.0 0.149 0.0 HOH
 7.357
 CB
 O
7anq 1 Q8NBP7 100.0 6e-167 X-RAY
 2021-10-20 HIS A:140 A:591 10.0 0.051 -64.2 147.0 10.0 0.051 0.0 HOH
 2.927
 N
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 HIS A:591 A:591 13.0 0.067 B -90.5 156.1