Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr1 | 55527141 | . | G | A | CCDS603.1:NM_174936.3:c.1775aGg>aAg_NP_777596.2:p.592R>K | Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 2p4e | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2007-04-10 | ARG | A:592 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:592 | A:592 | 110.0 | 0.489 | T | -52.8 | -28.0 | NA | NA | NA | |||||||||||||
| 6u2f | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | ARG | A:592 | A:592 | 38.0 | 0.169 | T | -63.2 | -29.9 | 38.0 | 0.169 | 0.0 | ||||||
| 5vlp | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2017-08-16 | ARG | A:592 | A:592 | 43.0 | 0.191 | T | -59.1 | -39.0 | 43.0 | 0.191 | 0.0 | ||||||
| 6u3i | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | ARG | A:592 | A:592 | 43.0 | 0.191 | T | -60.5 | -31.9 | 43.0 | 0.191 | 0.0 | ||||||
| 6u26 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:562 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:562 | B:592 | 72.0 | NA | T | -54.7 | -30.4 | NA | NA | NA | |||||||||||||
| 6u2n | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:562 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:562 | B:592 | 67.0 | NA | T | -51.3 | -36.5 | 67.0 | NA | NA | |||||||||||||
| 6u2p | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:562 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:562 | B:592 | 129.0 | 0.573 | T | -56.5 | -28.9 | 129.0 | 0.573 | 0.0 |
HOH |
6.143 |
N |
O |
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| 6u36 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:562 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:562 | B:592 | 21.0 | NA | T | -58.3 | -25.4 | 21.0 | NA | NA | |||||||||||||
| 6u38 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:562 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:562 | B:592 | 94.0 | 0.418 | T | -57.8 | -30.0 | 94.0 | 0.418 | 0.0 | |||||||||||||
| 6u3x | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:562 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:562 | B:592 | 104.0 | 0.462 | T | -54.7 | -27.8 | 104.0 | 0.462 | 0.0 | |||||||||||||
| 2pmw | 2 | Q5SZQ2 | 100.0 | 0.0 |
X-RAY |
2007-05-08 | ARG | B:440 | B:592 | 117.0 | 0.52 | T | -60.5 | -19.3 | 117.0 | 0.52 | 0.0 |
HOH |
6.316 |
N |
O |
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| 3p5b | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | ARG | B:440 | A:592 | 88.0 | 0.391 | T | -62.9 | -28.4 | 88.0 | 0.391 | 0.0 | ||||||
| 3p5c | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | ARG | B:440 | A:592 | 88.0 | 0.391 | T | -62.8 | -28.4 | 88.0 | 0.391 | 0.0 | ||||||
| 3bps | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2008-02-12 | ARG | B:440 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 3gcw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | ARG | B:440 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 3gcx | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | ARG | B:440 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 3sqo | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2012-05-16 | ARG | A:440 | A:592 | 130.0 | 0.578 | T | -47.7 | -44.6 | 130.0 | 0.578 | 0.0 |
HOH |
7.817 |
O |
O |
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| 4ne9 | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2014-09-10 | ARG | A:440 | A:592 | 100.0 | 0.444 | T | -50.8 | -32.2 | 100.0 | 0.444 | 0.0 | ||||||
| ARG | B:440 | B:592 | 101.0 | 0.449 | T | -50.5 | -33.3 | NA | NA | NA | |||||||||||||
| 4k8r | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2013-05-08 | ARG | B:440 | B:592 | 98.0 | 0.436 | T | -64.7 | -24.0 | 98.0 | 0.436 | 0.0 |
HOH |
3.135 |
NH1 |
O |
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| 5vl7 | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2017-08-16 | ARG | B:440 | B:592 | 86.0 | 0.382 | T | -47.2 | -37.5 | 86.0 | 0.382 | 0.0 | ||||||
| 2qtw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2007-09-18 | ARG | B:440 | B:592 | 112.0 | 0.498 | T | -63.6 | -24.5 | 112.0 | 0.498 | 0.0 |
HOH |
5.953 |
N |
O |
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| 7kev | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-24 | ARG | B:440 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 7kfa | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-10 | ARG | B:440 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 3m0c | 2 | Q8NBP7 | 99.44 | 0.0 |
X-RAY |
2011-03-16 | ARG | B:440 | B:592 | 113.0 | 0.502 | T | -63.9 | -24.4 | 113.0 | 0.502 | 0.0 | ||||||
| 3h42 | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2009-05-05 | ARG | B:440 | B:592 | 107.0 | 0.476 | T | -65.3 | -31.5 | 107.0 | 0.476 | 0.0 | ||||||
| 5oca | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2017-09-20 | ARG | B:440 | B:592 | 78.0 | 0.347 | T | -63.5 | -35.8 | 78.0 | 0.347 | 0.0 | ||||||
| 7anq | 1 | Q8NBP7 | 100.0 | 6e-167 |
X-RAY |
2021-10-20 | ARG | A:141 | A:592 | 51.0 | 0.227 | T | -55.0 | -28.1 | 51.0 | 0.227 | 0.0 |
HOH |
2.859 |
N |
O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q8nbp7-f1 | 1 | Q8NBP7 | 100.0 | 0.0 | ARG | A:592 | A:592 | 58.0 | 0.258 | T | -64.9 | -39.1 | |