Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr1 | 55527158 | . | G | A | CCDS603.1:NM_174936.3:c.1792Gct>Act_NP_777596.2:p.598A>T | Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 2p4e | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2007-04-10 | ALA | A:598 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | B:598 | A:598 | 0.0 | 0.0 | E | -113.5 | 129.9 | NA | NA | NA | |||||||||||||
| 6u2f | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | ALA | A:598 | A:598 | 1.0 | 0.009 | E | -115.1 | 122.3 | 1.0 | 0.009 | 0.0 |
CA |
9.941 |
HB1 |
CA |
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| 5vlp | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2017-08-16 | ALA | A:598 | A:598 | 1.0 | 0.009 | E | -103.2 | 120.1 | 0.0 | 0.0 | 0.009 |
B:None:0.009 |
|||||
| 6u3i | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | ALA | A:598 | A:598 | 2.0 | 0.017 | E | -100.5 | 127.7 | 0.0 | 0.0 | 0.017 |
C:None:0.017 |
CA HOH |
9.907 7.701 |
HB1 HA |
CA O |
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| 6u26 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ALA | A:568 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | B:568 | B:598 | 0.0 | 0.0 | E | -111.8 | 139.3 | NA | NA | NA | |||||||||||||
| 6u2n | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ALA | A:568 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | B:568 | B:598 | 0.0 | 0.0 | E | -122.0 | 133.2 | 0.0 | 0.0 | 0.0 |
HOH |
6.256 |
CA |
O |
|||||||||
| 6u2p | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ALA | A:568 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | B:568 | B:598 | 0.0 | 0.0 | E | -123.6 | 135.0 | 0.0 | 0.0 | 0.0 |
HOH |
8.043 |
CA |
O |
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| 6u36 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ALA | A:568 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | B:568 | B:598 | 0.0 | 0.0 | E | -121.0 | 132.5 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 6u38 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ALA | A:568 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | B:568 | B:598 | 0.0 | 0.0 | E | -126.7 | 133.8 | 0.0 | 0.0 | 0.0 |
HOH |
8.944 |
O |
O |
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| 6u3x | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ALA | A:568 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ALA | B:568 | B:598 | 0.0 | 0.0 | E | -112.8 | 138.3 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 2pmw | 2 | Q5SZQ2 | 100.0 | 0.0 |
X-RAY |
2007-05-08 | ALA | B:446 | B:598 | 0.0 | 0.0 | E | -112.5 | 137.1 | 0.0 | 0.0 | 0.0 |
HOH |
6.186 |
C |
O |
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| 3p5b | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | ALA | B:446 | A:598 | 0.0 | 0.0 | E | -124.3 | 132.0 | 0.0 | 0.0 | 0.0 | ||||||
| 3p5c | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | ALA | B:446 | A:598 | 1.0 | 0.009 | E | -124.3 | 132.0 | 1.0 | 0.009 | 0.0 | ||||||
| 3bps | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2008-02-12 | ALA | B:446 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 3gcw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | ALA | B:446 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 3gcx | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | ALA | B:446 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 3sqo | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2012-05-16 | ALA | A:446 | A:598 | 0.0 | 0.0 | E | -125.5 | 123.5 | 0.0 | 0.0 | 0.0 |
HOH |
9.700 |
O |
O |
||
| 4ne9 | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2014-09-10 | ALA | A:446 | A:598 | 0.0 | 0.0 | E | -111.3 | 130.8 | 0.0 | 0.0 | 0.0 | ||||||
| ALA | B:446 | B:598 | 0.0 | 0.0 | E | -111.7 | 133.4 | NA | NA | NA | |||||||||||||
| 4k8r | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2013-05-08 | ALA | B:446 | B:598 | 0.0 | 0.0 | E | -102.1 | 144.9 | 0.0 | 0.0 | 0.0 |
HOH |
7.286 |
O |
O |
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| 5vl7 | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2017-08-16 | ALA | B:446 | B:598 | 0.0 | 0.0 | E | -128.7 | 142.0 | 0.0 | 0.0 | 0.0 | ||||||
| 2qtw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2007-09-18 | ALA | B:446 | B:598 | 0.0 | 0.0 | E | -115.8 | 133.0 | 0.0 | 0.0 | 0.0 |
HOH |
5.501 |
O |
O |
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| 7kev | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-24 | ALA | B:446 | B:598 | 0.0 | 0.0 | E | -79.0 | 144.7 | 0.0 | 0.0 | 0.0 | ||||||
| 7kfa | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-10 | ALA | B:446 | B:598 | 0.0 | 0.0 | E | -91.1 | 139.7 | 0.0 | 0.0 | 0.0 | ||||||
| 3m0c | 2 | Q8NBP7 | 99.44 | 0.0 |
X-RAY |
2011-03-16 | ALA | B:446 | B:598 | 0.0 | 0.0 | E | -115.7 | 133.0 | 0.0 | 0.0 | 0.0 | ||||||
| 3h42 | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2009-05-05 | ALA | B:446 | B:598 | 0.0 | 0.0 | E | -121.4 | 132.3 | 0.0 | 0.0 | 0.0 |
HOH |
6.154 |
C |
O |
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| 5oca | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2017-09-20 | ALA | B:446 | B:598 | 0.0 | 0.0 | E | -113.0 | 130.9 | 0.0 | 0.0 | 0.0 |
HOH |
6.272 |
C |
O |
||
| 7anq | 1 | Q8NBP7 | 100.0 | 6e-167 |
X-RAY |
2021-10-20 | ALA | A:147 | A:598 | 0.0 | 0.0 | E | -100.2 | 123.7 | 0.0 | 0.0 | 0.0 |
HOH |
7.259 |
O |
O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q8nbp7-f1 | 1 | Q8NBP7 | 100.0 | 0.0 | ALA | A:598 | A:598 | 0.0 | 0.0 | E | -100.0 | 121.5 | |