Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55527213 . C A CCDS603.1:NM_174936.3:c.1847cCg>cAg_NP_777596.2:p.616P>Q Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
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label_comp_id: 
auth_asym_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 PRO A:616 NA:NA DO NA DO DO DO NA NA NA
PRO B:616 A:616 74.0 0.51 E -34.1 133.6 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 PRO A:616 A:616 111.0 0.766 S -67.4 -56.3 111.0 0.766 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 PRO A:616 A:616 109.0 0.752 S -75.2 -56.2 109.0 0.752 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 PRO A:616 A:616 108.0 0.745 S -70.1 -52.5 108.0 0.745 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 PRO A:586 NA:NA DO NA DO DO DO NA NA NA
PRO B:586 B:616 161.0 1.0 -91.2 360.0 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 PRO A:586 NA:NA DO NA DO DO DO NA NA NA
PRO B:586 B:616 148.0 1.0 -94.0 360.0 148.0 1.0 0.0 HOH
 9.289
 N
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 PRO A:586 NA:NA DO NA DO DO DO NA NA NA
PRO B:586 B:616 132.0 0.91 -93.0 360.0 132.0 0.91 0.0
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 PRO A:586 NA:NA DO NA DO DO DO NA NA NA
PRO B:586 B:616 104.0 0.717 S -62.0 -56.6 104.0 0.717 0.0
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 PRO A:586 NA:NA DO NA DO DO DO NA NA NA
PRO B:586 B:616 105.0 0.724 S -62.2 -52.4 105.0 0.724 0.0
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 PRO A:586 NA:NA DO NA DO DO DO NA NA NA
PRO B:586 B:616 139.0 0.959 -75.9 360.0 139.0 0.959 0.0
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 PRO B:464 B:616 97.0 0.669 S -60.5 -51.7 97.0 0.669 0.0 HOH
 7.163
 CD
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 PRO B:464 A:616 92.0 0.634 -89.8 126.2 92.0 0.634 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 PRO B:464 A:616 91.0 0.628 -89.9 126.2 91.0 0.628 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 PRO B:464 A:616 101.0 0.697 S -55.4 -96.5 101.0 0.697 0.0 HOH
 7.420
 CD
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 PRO B:464 A:616 102.0 0.703 S -57.6 -92.4 102.0 0.703 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 PRO B:464 A:616 100.0 0.69 S -57.9 -92.5 100.0 0.69 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 PRO A:464 A:616 87.0 0.6 E -48.4 174.7 87.0 0.6 0.0
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 PRO A:464 A:616 89.0 0.614 -44.1 136.1 89.0 0.614 0.0
PRO B:464 B:616 91.0 0.628 -45.6 136.3 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 PRO B:464 B:616 119.0 0.821 S -71.4 -41.1 119.0 0.821 0.0 HOH
 8.760
 O
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 PRO B:464 B:616 137.0 0.945 -76.0 360.0 137.0 0.945 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 PRO B:464 B:616 127.0 0.876 -36.8 360.0 127.0 0.876 0.0 HOH
 9.146
 N
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 PRO B:464 NA:NA DO NA DO DO DO NA NA NA
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 PRO B:464 NA:NA DO NA DO DO DO NA NA NA
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 PRO B:464 B:616 128.0 0.883 -36.8 360.0 128.0 0.883 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 PRO B:464 B:616 108.0 0.745 S -61.6 -52.4 108.0 0.745 0.0 HOH
 9.257
 CD
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 PRO B:464 B:616 104.0 0.717 S -70.7 -43.2 104.0 0.717 0.0 HOH
 9.171
 CD
 O
7anq 1 Q8NBP7 100.0 6e-167 X-RAY
 2021-10-20 PRO A:165 A:616 75.0 0.517 S -65.3 -56.9 75.0 0.517 0.0 HOH
 9.369
 N
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 PRO A:616 A:616 101.0 0.697 S -67.0 127.2