Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55527222 . A C CCDS603.1:NM_174936.3:c.1856cAg>cCg_NP_777596.2:p.619Q>P Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 GLN A:619 NA:NA DO NA DO DO DO NA NA NA
GLN B:619 A:619 92.0 0.511 -82.1 127.5 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 GLN A:619 A:619 166.0 0.922 S -113.1 130.4 166.0 0.922 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 GLN A:619 NA:NA DO NA DO DO DO NA NA NA
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 GLN A:619 A:619 181.0 1.0 S -106.4 108.9 181.0 1.0 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLN A:589 NA:NA DO NA DO DO DO NA NA NA
GLN B:589 NA:NA DO NA DO DO DO NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLN A:589 NA:NA DO NA DO DO DO NA NA NA
GLN B:589 B:619 160.0 0.889 360.0 145.7 160.0 0.889 0.0 HOH
 7.410
 NE2
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLN A:589 NA:NA DO NA DO DO DO NA NA NA
GLN B:589 B:619 151.0 0.839 360.0 124.9 151.0 0.839 0.0
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLN A:589 NA:NA DO NA DO DO DO NA NA NA
GLN B:589 B:619 96.0 NA S -91.5 82.2 96.0 NA NA
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLN A:589 NA:NA DO NA DO DO DO NA NA NA
GLN B:589 B:619 166.0 0.922 S -66.2 -66.3 166.0 0.922 0.0
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLN A:589 NA:NA DO NA DO DO DO NA NA NA
GLN B:589 B:619 145.0 0.806 360.0 133.8 145.0 0.806 0.0
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 GLN B:467 B:619 184.0 1.0 S -58.9 -46.8 184.0 1.0 0.0 HOH
 6.532
 O
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 GLN B:467 A:619 63.0 0.35 -106.7 -156.8 63.0 0.35 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 GLN B:467 A:619 65.0 0.361 -106.7 -156.9 65.0 0.361 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 GLN B:467 A:619 104.0 0.578 -123.3 -161.7 104.0 0.578 0.0
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 GLN B:467 A:619 117.0 0.65 -105.3 -158.5 117.0 0.65 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 GLN B:467 A:619 100.0 0.556 -126.0 -155.7 100.0 0.556 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 GLN A:467 A:619 103.0 0.572 -78.9 156.6 103.0 0.572 0.0
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 GLN A:467 A:619 90.0 0.5 -80.8 130.4 90.0 0.5 0.0
GLN B:467 B:619 90.0 0.5 -80.5 131.2 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 GLN B:467 B:619 202.0 1.0 S -100.7 -43.5 202.0 1.0 0.0 HOH
 3.588
 O
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 GLN B:467 B:619 145.0 0.806 360.0 177.7 145.0 0.806 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 GLN B:467 B:619 118.0 0.656 360.0 119.1 118.0 0.656 0.0 HOH
 4.898
 NE2
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 GLN B:467 B:619 124.0 0.689 360.0 158.8 124.0 0.689 0.0
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 GLN B:467 B:619 133.0 0.739 360.0 148.2 133.0 0.739 0.0
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 GLN B:467 B:619 118.0 0.656 360.0 119.1 118.0 0.656 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 GLN B:467 B:619 200.0 1.0 S -73.9 -13.7 200.0 1.0 0.0 HOH
 8.080
 NE2
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 GLN B:467 B:619 177.0 0.983 S -89.3 52.8 177.0 0.983 0.0 HOH
 8.373
 N
 O
7anq 1 Q8NBP7 100.0 6e-167 X-RAY
 2021-10-20 GLN A:168 A:619 109.0 0.606 57.9 -149.6 109.0 0.606 0.0 HOH
 4.611
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 GLN A:619 A:619 177.0 0.983 S -84.7 104.7