Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55529064 . G A CCDS603.1:NM_174936.3:c.1886gGc>gAc_NP_777596.2:p.629G>D Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 GLY A:629 NA:NA DO NA DO DO DO NA NA NA
GLY B:629 A:629 59.0 0.787 T 89.8 -9.7 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 GLY A:629 A:629 63.0 0.84 T 97.5 -35.2 63.0 0.84 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 GLY A:629 A:629 63.0 0.84 T 105.0 -21.5 63.0 0.84 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 GLY A:629 A:629 61.0 0.813 T 102.2 -15.8 61.0 0.813 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLY A:599 NA:NA DO NA DO DO DO NA NA NA
GLY B:599 B:629 55.0 0.733 T 90.8 -7.1 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLY A:599 NA:NA DO NA DO DO DO NA NA NA
GLY B:599 B:629 49.0 0.653 T 95.9 -5.1 49.0 0.653 0.0 HOH
 3.116
 O
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLY A:599 NA:NA DO NA DO DO DO NA NA NA
GLY B:599 B:629 65.0 0.867 T 91.8 -9.2 65.0 0.867 0.0 EDO
HOH
 7.128
2.768
 C
O
 C2
O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLY A:599 NA:NA DO NA DO DO DO NA NA NA
GLY B:599 B:629 52.0 0.693 T 91.4 -11.4 52.0 0.693 0.0 HOH
 2.718
 O
 O
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLY A:599 NA:NA DO NA DO DO DO NA NA NA
GLY B:599 B:629 50.0 0.667 T 92.6 -11.1 50.0 0.667 0.0 HOH
 8.197
 O
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLY A:599 NA:NA DO NA DO DO DO NA NA NA
GLY B:599 B:629 49.0 0.653 T 96.6 -11.7 49.0 0.653 0.0 HOH
 2.735
 O
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 GLY B:477 B:629 66.0 0.88 T 96.3 -5.4 66.0 0.88 0.0 HOH
 3.224
 O
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 GLY B:477 A:629 34.0 0.453 T 108.7 -22.0 34.0 0.453 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 GLY B:477 A:629 35.0 0.467 T 108.7 -22.0 35.0 0.467 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 GLY B:477 A:629 63.0 0.84 T 95.8 -23.6 63.0 0.84 0.0 HOH
 2.608
 O
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 GLY B:477 A:629 65.0 0.867 T 101.1 -34.5 65.0 0.867 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 GLY B:477 A:629 65.0 0.867 T 82.9 4.9 65.0 0.867 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 GLY A:477 A:629 67.0 0.893 T 84.4 13.6 67.0 0.893 0.0 HOH
 9.504
 O
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 GLY A:477 A:629 51.0 0.68 T 92.1 0.1 51.0 0.68 0.0
GLY B:477 B:629 54.0 0.72 T 92.0 0.9 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 GLY B:477 B:629 65.0 0.867 T 112.7 -32.7 65.0 0.867 0.0 HOH
 3.584
 O
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 GLY B:477 B:629 51.0 0.68 T 139.6 -7.5 51.0 0.68 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 GLY B:477 B:629 51.0 0.68 T 88.2 -2.5 51.0 0.68 0.0 HOH
 3.004
 O
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 GLY B:477 B:629 49.0 0.653 T 114.1 -24.3 49.0 0.653 0.0
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 GLY B:477 B:629 57.0 0.76 T 99.3 -12.4 57.0 0.76 0.0 HOH
 9.086
 O
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 GLY B:477 B:629 49.0 0.653 T 88.0 -2.5 49.0 0.653 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 GLY B:477 B:629 56.0 0.747 T 101.0 -16.9 56.0 0.747 0.0 HOH
 2.853
 O
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 GLY B:477 B:629 54.0 0.72 T 94.2 -17.4 54.0 0.72 0.0 HOH
 4.511
 O
 O
7anq 1 Q8NBP7 100.0 6e-167 X-RAY
 2021-10-20 GLY A:178 A:629 50.0 0.667 T 110.0 -18.2 50.0 0.667 0.0 HOH
 2.945
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 GLY A:629 A:629 55.0 0.733 T 75.9 5.9