Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55529084 . A C CCDS603.1:NM_174936.3:c.1906Agt>Cgt_NP_777596.2:p.636S>R Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 SER A:636 NA:NA DO NA DO DO DO NA NA NA
SER B:636 A:636 30.0 0.261 E -152.0 167.9 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 SER A:636 A:636 29.0 0.252 E -136.0 153.8 29.0 0.252 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 SER A:636 A:636 29.0 0.252 E -140.1 159.5 29.0 0.252 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 SER A:636 A:636 27.0 0.235 E -123.5 161.0 27.0 0.235 0.0 HOH
 2.740
 HG
 O
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 SER A:606 NA:NA DO NA DO DO DO NA NA NA
SER B:606 B:636 31.0 0.27 E -151.4 169.4 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 SER A:606 NA:NA DO NA DO DO DO NA NA NA
SER B:606 B:636 31.0 0.27 E -145.5 174.2 31.0 0.27 0.0 HOH
 4.035
 OG
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 SER A:606 NA:NA DO NA DO DO DO NA NA NA
SER B:606 B:636 30.0 0.261 E -153.2 171.4 30.0 0.261 0.0 EDO
HOH
 5.473
3.117
 N
OG
 O1
O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 SER A:606 NA:NA DO NA DO DO DO NA NA NA
SER B:606 B:636 23.0 0.2 E -145.9 161.7 23.0 0.2 0.0
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 SER A:606 NA:NA DO NA DO DO DO NA NA NA
SER B:606 B:636 23.0 0.2 E -149.6 177.0 23.0 0.2 0.0 HOH
 2.761
 OG
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 SER A:606 NA:NA DO NA DO DO DO NA NA NA
SER B:606 B:636 18.0 0.157 E -154.8 165.4 18.0 0.157 0.0 HOH
 5.304
 CA
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 SER B:484 B:636 30.0 0.261 E -156.0 167.4 30.0 0.261 0.0 HOH
 3.360
 CB
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 SER B:484 A:636 26.0 0.226 E -140.7 161.1 26.0 0.226 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 SER B:484 A:636 27.0 0.235 E -140.7 161.1 27.0 0.235 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 SER B:484 A:636 58.0 0.504 E -135.1 168.7 58.0 0.504 0.0 HOH
 2.781
 OG
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 SER B:484 A:636 53.0 0.461 E -127.4 167.3 53.0 0.461 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 SER B:484 A:636 53.0 0.461 E -129.0 171.0 53.0 0.461 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 SER A:484 A:636 37.0 0.322 E -153.5 158.7 37.0 0.322 0.0 HOH
 5.273
 CA
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 SER A:484 A:636 31.0 0.27 E -150.5 166.3 31.0 0.27 0.0
SER B:484 B:636 33.0 0.287 E -150.6 165.2 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 SER B:484 B:636 28.0 0.243 E -150.6 157.1 28.0 0.243 0.0 HOH
 3.254
 OG
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 SER B:484 B:636 25.0 0.217 E -164.1 161.7 25.0 0.217 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 SER B:484 B:636 32.0 0.278 E -154.7 166.0 32.0 0.278 0.0 HOH
 2.979
 OG
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 SER B:484 B:636 23.0 0.2 E -144.9 156.8 23.0 0.2 0.0
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 SER B:484 B:636 24.0 0.209 E -152.6 167.4 24.0 0.209 0.0 HOH
 4.971
 N
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 SER B:484 B:636 31.0 0.27 E -154.6 166.1 31.0 0.27 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 SER B:484 B:636 40.0 0.348 E -162.8 156.0 40.0 0.348 0.0 HOH
 3.096
 OG
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 SER B:484 B:636 36.0 0.313 E -160.4 154.7 36.0 0.313 0.0 HOH
 2.986
 CB
 O
7anq 1 Q8NBP7 100.0 6e-167 X-RAY
 2021-10-20 SER A:185 A:636 33.0 0.287 E -153.5 171.3 33.0 0.287 0.0 HOH
 2.708
 OG
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 SER A:636 A:636 29.0 0.252 E -146.1 162.8