Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr1 | 55529108 | . | G | A | CCDS603.1:NM_174936.3:c.1930Gtc>Atc_NP_777596.2:p.644V>I | Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 2p4e | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2007-04-10 | VAL | A:644 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:644 | A:644 | 25.0 | 0.161 | E | -87.6 | 129.5 | NA | NA | NA | |||||||||||||
| 6u2f | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | VAL | A:644 | A:644 | 0.0 | 0.0 | E | -134.2 | 140.7 | 0.0 | 0.0 | 0.0 | ||||||
| 5vlp | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2017-08-16 | VAL | A:644 | A:644 | 1.0 | 0.006 | E | -92.0 | 133.9 | 1.0 | 0.006 | 0.0 | ||||||
| 6u3i | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | VAL | A:644 | A:644 | 0.0 | 0.0 | E | -132.6 | 143.1 | 0.0 | 0.0 | 0.0 | ||||||
| 6u26 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:614 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:614 | B:644 | 19.0 | 0.123 | E | -94.0 | 144.6 | NA | NA | NA | |||||||||||||
| 6u2n | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:614 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:614 | B:644 | 16.0 | NA | E | -89.7 | 139.0 | 16.0 | NA | NA |
HOH |
7.390 |
CB |
O |
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| 6u2p | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:614 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:614 | B:644 | 23.0 | 0.148 | E | -102.0 | 139.8 | 23.0 | 0.148 | 0.0 |
HOH |
5.461 |
CG2 |
O |
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| 6u36 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:614 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:614 | B:644 | 24.0 | 0.155 | E | -108.9 | 133.2 | 24.0 | 0.155 | 0.0 | |||||||||||||
| 6u38 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:614 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:614 | B:644 | 19.0 | 0.123 | E | -115.8 | 122.9 | 19.0 | 0.123 | 0.0 |
HOH |
6.354 |
CG1 |
O |
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| 6u3x | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | VAL | A:614 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:614 | B:644 | 31.0 | 0.2 | E | -122.0 | 135.9 | 31.0 | 0.2 | 0.0 |
HOH |
6.175 |
CG2 |
O |
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| 2pmw | 2 | Q5SZQ2 | 100.0 | 0.0 |
X-RAY |
2007-05-08 | VAL | B:492 | B:644 | 29.0 | 0.187 | E | -83.3 | 139.3 | 29.0 | 0.187 | 0.0 |
HOH |
4.581 |
CG2 |
O |
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| 3p5b | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | VAL | B:492 | A:644 | 14.0 | 0.09 | E | -124.9 | 143.5 | 14.0 | 0.09 | 0.0 | ||||||
| 3p5c | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | VAL | B:492 | A:644 | 14.0 | 0.09 | E | -124.9 | 143.5 | 14.0 | 0.09 | 0.0 | ||||||
| 3bps | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2008-02-12 | VAL | B:492 | A:644 | 17.0 | 0.11 | E | -73.8 | 127.8 | 17.0 | 0.11 | 0.0 | ||||||
| 3gcw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | VAL | B:492 | A:644 | 21.0 | 0.135 | E | -101.2 | 118.7 | 21.0 | 0.135 | 0.0 | ||||||
| 3gcx | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | VAL | B:492 | A:644 | 19.0 | 0.123 | E | -92.6 | 126.8 | 19.0 | 0.123 | 0.0 | ||||||
| 3sqo | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2012-05-16 | VAL | A:492 | A:644 | 25.0 | 0.161 | E | -112.2 | 134.5 | 25.0 | 0.161 | 0.0 |
HOH |
7.693 |
CG2 |
O |
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| 4ne9 | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2014-09-10 | VAL | A:492 | A:644 | 21.0 | 0.135 | E | -87.1 | 126.4 | 21.0 | 0.135 | 0.0 | ||||||
| VAL | B:492 | B:644 | 21.0 | 0.135 | E | -86.4 | 125.6 | NA | NA | NA | |||||||||||||
| 4k8r | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2013-05-08 | VAL | B:492 | B:644 | 12.0 | 0.077 | -135.2 | 117.7 | 12.0 | 0.077 | 0.0 |
HOH |
5.464 |
CG2 |
O |
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| 5vl7 | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2017-08-16 | VAL | B:492 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 2qtw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2007-09-18 | VAL | B:492 | B:644 | 24.0 | 0.155 | E | -90.3 | 136.6 | 24.0 | 0.155 | 0.0 |
HOH |
5.301 |
CG2 |
O |
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| 7kev | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-24 | VAL | B:492 | B:644 | 16.0 | 0.103 | E | -107.3 | 135.1 | 16.0 | 0.103 | 0.0 | ||||||
| 7kfa | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-10 | VAL | B:492 | B:644 | 15.0 | 0.097 | E | -73.4 | 122.8 | 15.0 | 0.097 | 0.0 |
HOH |
6.044 |
CG1 |
O |
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| 3m0c | 2 | Q8NBP7 | 99.44 | 0.0 |
X-RAY |
2011-03-16 | VAL | B:492 | B:644 | 23.0 | 0.148 | E | -90.4 | 136.6 | 23.0 | 0.148 | 0.0 | ||||||
| 3h42 | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2009-05-05 | VAL | B:492 | B:644 | 20.0 | 0.129 | E | -112.8 | 123.1 | 20.0 | 0.129 | 0.0 |
HOH |
7.319 |
CG1 |
O |
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| 5oca | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2017-09-20 | VAL | B:492 | B:644 | 18.0 | 0.116 | -126.7 | 119.0 | 18.0 | 0.116 | 0.0 |
HOH |
4.055 |
CG2 |
O |
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| 7anq | 1 | Q8NBP7 | 100.0 | 6e-167 |
X-RAY |
2021-10-20 | VAL | A:193 | A:644 | 23.0 | 0.148 | E | -111.7 | 125.4 | 23.0 | 0.148 | 0.0 |
HOH |
4.967 |
CG1 |
O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q8nbp7-f1 | 1 | Q8NBP7 | 100.0 | 0.0 | VAL | A:644 | A:644 | 0.0 | 0.0 | E | -111.7 | 120.6 | |