Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55529153 . C A CCDS603.1:NM_174936.3:c.1975Cgg>Agg_NP_777596.2:p.659R>R Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
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label_seq_id: 
label_comp_id: 
auth_asym_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 ARG A:659 NA:NA DO NA DO DO DO NA NA NA
ARG B:659 A:659 185.0 0.822 -82.4 360.0 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ARG A:659 A:659 91.0 0.404 -111.3 -173.1 91.0 0.404 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 ARG A:659 A:659 164.0 0.729 -97.4 360.0 164.0 0.729 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ARG A:659 A:659 91.0 0.404 -97.0 173.3 91.0 0.404 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:629 NA:NA DO NA DO DO DO NA NA NA
ARG B:629 B:659 98.0 NA -98.4 360.0 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:629 NA:NA DO NA DO DO DO NA NA NA
ARG B:629 B:659 107.0 NA -73.7 360.0 107.0 NA NA
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:629 NA:NA DO NA DO DO DO NA NA NA
ARG B:629 B:659 187.0 0.831 -77.6 360.0 187.0 0.831 0.0 HOH
 9.860
 NH2
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:629 NA:NA DO NA DO DO DO NA NA NA
ARG B:629 B:659 100.0 NA -75.2 360.0 100.0 NA NA
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:629 NA:NA DO NA DO DO DO NA NA NA
ARG B:629 B:659 95.0 NA -121.6 360.0 95.0 NA NA
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:629 NA:NA DO NA DO DO DO NA NA NA
ARG B:629 B:659 186.0 0.827 -90.0 360.0 186.0 0.827 0.0
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 ARG B:507 B:659 230.0 1.0 -76.2 360.0 230.0 1.0 0.0 HOH
 4.815
 N
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ARG B:507 A:659 91.0 NA -73.3 360.0 91.0 NA NA
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ARG B:507 A:659 91.0 NA -73.2 360.0 91.0 NA NA
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 ARG B:507 A:659 127.0 0.564 E -146.0 133.5 127.0 0.564 0.0 HOH
 5.383
 NH2
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ARG B:507 A:659 215.0 0.956 64.8 360.0 215.0 0.956 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ARG B:507 A:659 244.0 1.0 -126.9 360.0 244.0 1.0 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 ARG A:507 A:659 173.0 0.769 -106.9 360.0 173.0 0.769 0.0
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 ARG A:507 A:659 182.0 0.809 -79.4 360.0 182.0 0.809 0.0
ARG B:507 B:659 184.0 0.818 -78.8 360.0 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 ARG B:507 B:659 176.0 0.782 -53.5 360.0 176.0 0.782 0.0 HOH
 2.885
 O
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 ARG B:507 B:659 228.0 1.0 -112.5 360.0 228.0 1.0 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 ARG B:507 B:659 183.0 0.813 -84.7 360.0 183.0 0.813 0.0 HOH
 3.608
 CA
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 ARG B:507 B:659 212.0 0.942 -130.1 360.0 212.0 0.942 0.0
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 ARG B:507 B:659 212.0 0.942 -131.3 360.0 212.0 0.942 0.0
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 ARG B:507 B:659 180.0 0.8 -84.7 360.0 180.0 0.8 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 ARG B:507 B:659 199.0 0.884 -85.6 360.0 199.0 0.884 0.0
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 ARG B:507 B:659 215.0 0.956 -67.2 360.0 215.0 0.956 0.0
7anq 1 Q8NBP7 100.0 6e-167 X-RAY
 2021-10-20 ARG A:208 A:659 113.0 0.502 -82.8 14.5 113.0 0.502 0.0 SO4
HOH
 9.422
4.723
 NH2
NH1
 O1
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 ARG A:659 A:659 98.0 0.436 -72.4 148.9