Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55529201 . G A CCDS603.1:NM_174936.3:c.2023Gtt>Att_NP_777596.2:p.675V>I Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 VAL A:675 NA:NA DO NA DO DO DO NA NA NA
VAL B:675 A:675 15.0 0.097 E -134.4 112.5 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 VAL A:675 A:675 13.0 0.084 E -102.6 126.5 13.0 0.084 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 VAL A:675 A:675 12.0 0.077 E -112.4 117.9 12.0 0.077 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 VAL A:675 A:675 12.0 0.077 E -107.2 123.7 12.0 0.077 0.0 HOH
 3.367
 HG11
 O
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:645 NA:NA DO NA DO DO DO NA NA NA
VAL B:645 B:675 13.0 0.084 E -127.0 113.6 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:645 NA:NA DO NA DO DO DO NA NA NA
VAL B:645 B:675 13.0 0.084 E -117.4 122.0 13.0 0.084 0.0 HOH
 5.223
 O
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:645 NA:NA DO NA DO DO DO NA NA NA
VAL B:645 B:675 12.0 0.077 E -122.9 117.4 12.0 0.077 0.0 EDO
HOH
 7.232
3.089
 O
O
 O1
O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:645 NA:NA DO NA DO DO DO NA NA NA
VAL B:645 B:675 13.0 0.084 E -114.2 116.0 13.0 0.084 0.0
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:645 NA:NA DO NA DO DO DO NA NA NA
VAL B:645 B:675 15.0 0.097 E -111.8 116.8 15.0 0.097 0.0 HOH
 3.099
 O
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:645 NA:NA DO NA DO DO DO NA NA NA
VAL B:645 B:675 17.0 0.11 E -113.5 122.3 17.0 0.11 0.0 HOH
 8.392
 O
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 VAL B:523 B:675 13.0 0.084 E -127.6 114.9 13.0 0.084 0.0 HOH
 5.328
 O
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 VAL B:523 A:675 16.0 0.103 E -110.9 126.5 16.0 0.103 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 VAL B:523 A:675 17.0 0.11 E -110.9 126.5 17.0 0.11 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 VAL B:523 A:675 16.0 0.103 E -124.3 113.9 16.0 0.103 0.0 HOH
 2.881
 O
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 VAL B:523 A:675 17.0 0.11 E -115.6 117.7 17.0 0.11 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 VAL B:523 A:675 15.0 0.097 E -119.6 118.0 15.0 0.097 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 VAL A:523 A:675 22.0 0.142 E -123.0 118.6 22.0 0.142 0.0 HOH
 8.954
 O
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 VAL A:523 A:675 15.0 0.097 E -128.1 111.3 15.0 0.097 0.0
VAL B:523 B:675 17.0 0.11 E -126.5 110.4 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 VAL B:523 B:675 20.0 0.129 E -117.5 111.1 20.0 0.129 0.0 HOH
 5.064
 CG1
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 VAL B:523 B:675 16.0 0.103 E -119.8 120.0 16.0 0.103 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 VAL B:523 B:675 14.0 0.09 E -130.3 118.9 14.0 0.09 0.0 HOH
 3.117
 O
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 VAL B:523 B:675 17.0 0.11 E -130.3 109.5 17.0 0.11 0.0
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 VAL B:523 B:675 14.0 0.09 E -124.4 118.4 14.0 0.09 0.0 HOH
 6.847
 O
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 VAL B:523 B:675 14.0 0.09 E -130.3 118.8 14.0 0.09 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 VAL B:523 B:675 20.0 0.129 E -116.0 116.7 20.0 0.129 0.0 HOH
 5.601
 CG2
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 VAL B:523 B:675 20.0 0.129 E -121.7 111.2 20.0 0.129 0.0 HOH
 3.151
 O
 O
7anq 1 Q8NBP7 100.0 6e-167 X-RAY
 2021-10-20 VAL A:224 A:675 16.0 0.103 E -116.0 115.5 16.0 0.103 0.0 HOH
 3.044
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 VAL A:675 A:675 9.0 0.058 E -122.4 111.9