Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55529216 . C A CCDS603.1:NM_174936.3:c.2038Cgg>Agg_NP_777596.2:p.680R>R Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 ARG A:680 NA:NA DO NA DO DO DO NA NA NA
ARG B:680 A:680 100.0 0.444 E -141.0 157.7 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ARG A:680 A:680 88.0 0.391 E -158.8 154.3 88.0 0.391 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 ARG A:680 A:680 88.0 0.391 E -155.3 155.6 88.0 0.391 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ARG A:680 A:680 83.0 0.369 E -161.8 154.3 83.0 0.369 0.0 HOH
 7.751
 O
 O
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:650 NA:NA DO NA DO DO DO NA NA NA
ARG B:650 B:680 101.0 0.449 E -150.5 156.7 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:650 NA:NA DO NA DO DO DO NA NA NA
ARG B:650 B:680 102.0 0.453 E -153.7 155.0 102.0 0.453 0.0 HOH
 3.018
 NH1
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:650 NA:NA DO NA DO DO DO NA NA NA
ARG B:650 B:680 101.0 0.449 E -152.8 157.1 101.0 0.449 0.0 EDO
HOH
 7.348
3.318
 CG
NH2
 C2
O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:650 NA:NA DO NA DO DO DO NA NA NA
ARG B:650 B:680 87.0 0.387 E -158.9 160.5 87.0 0.387 0.0 HOH
 3.701
 CB
 O
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:650 NA:NA DO NA DO DO DO NA NA NA
ARG B:650 B:680 85.0 0.378 E -158.3 162.3 85.0 0.378 0.0 HOH
 7.585
 O
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ARG A:650 NA:NA DO NA DO DO DO NA NA NA
ARG B:650 B:680 93.0 0.413 E -153.8 161.9 93.0 0.413 0.0 HOH
 4.439
 CB
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 ARG B:528 B:680 103.0 0.458 E -143.4 157.1 103.0 0.458 0.0 HOH
 3.618
 CA
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ARG B:528 A:680 39.0 0.173 E -132.9 137.9 39.0 0.173 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ARG B:528 A:680 38.0 0.169 E -132.8 138.0 38.0 0.169 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 ARG B:528 A:680 101.0 0.449 E -149.9 161.4 101.0 0.449 0.0 HOH
 3.751
 CB
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ARG B:528 A:680 100.0 0.444 E -150.5 159.3 100.0 0.444 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ARG B:528 A:680 98.0 0.436 E -149.5 162.2 98.0 0.436 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 ARG A:528 A:680 97.0 0.431 E -150.9 172.6 97.0 0.431 0.0 HOH
 5.066
 O
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 ARG A:528 A:680 69.0 0.307 E -147.2 148.1 69.0 0.307 0.0 HOH
 8.517
 O
 O
ARG B:528 B:680 68.0 0.302 E -147.7 148.5 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 ARG B:528 B:680 60.0 0.267 E -161.9 156.8 60.0 0.267 0.0 HOH
 3.513
 CB
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 ARG B:528 B:680 92.0 0.409 -143.0 174.3 92.0 0.409 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 ARG B:528 B:680 100.0 0.444 E -152.5 163.6 100.0 0.444 0.0 HOH
 2.519
 NE
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 ARG B:528 B:680 95.0 0.422 E -134.6 179.9 95.0 0.422 0.0
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 ARG B:528 B:680 98.0 0.436 E -159.8 147.6 98.0 0.436 0.0
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 ARG B:528 B:680 98.0 0.436 E -152.6 163.6 98.0 0.436 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 ARG B:528 B:680 91.0 0.404 E -159.3 170.3 91.0 0.404 0.0 HOH
 3.653
 CB
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 ARG B:528 B:680 92.0 0.409 E -158.0 171.2 92.0 0.409 0.0 HOH
 3.620
 CA
 O
7anq 1 Q8NBP7 100.0 6e-167 X-RAY
 2021-10-20 ARG A:229 A:680 89.0 0.396 E -152.1 164.6 89.0 0.396 0.0 HOH
 4.293
 CB
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 ARG A:680 A:680 74.0 0.329 E -146.0 156.4