Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 75830746 . T A CCDS7340.1:NM_003373.3:c.404aTt>aAt_NP_003364.1:p.135I>N Homo sapiens vinculin (VCL), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6upw 1 P18206 100.0 0.0 EM
 2020-09-30 ILE A:135 NA:NA DO NA DO DO DO NA NA NA
ILE C:135 NA:NA DO NA DO DO DO NA NA NA
7ktt 1 P18206 100.0 0.0 EM
 2021-01-27 ILE A:135 A:135 39.0 0.223 H -62.2 -51.7 39.0 0.223 0.0
7ktu 1 P18206 100.0 0.0 EM
 2021-01-27 ILE A:135 A:135 60.0 0.343 H -68.8 -48.0 60.0 0.343 0.0
7ktv 1 P18206 100.0 0.0 EM
 2021-01-27 ILE A:135 A:135 27.0 0.154 H -61.8 -56.6 27.0 0.154 0.0
7ktw 1 P18206 100.0 0.0 EM
 2021-01-27 ILE A:135 A:135 49.0 0.28 H -63.2 -45.6 49.0 0.28 0.0
1tr2 1 P18206 90.83 0.0 X-RAY
 2005-11-15 ILE A:135 A:135 19.0 0.109 H -49.6 -36.4 19.0 0.109 0.0 HOH
 7.667
 C
 O
ILE B:135 B:135 20.0 0.114 H -63.3 -29.6 NA NA NA
6fuy 1 P18206 90.48 0.0 X-RAY
 2018-03-14 ILE A:135 A:135 17.0 0.097 H -66.8 -31.5 17.0 0.097 0.0 HOH
 8.327
 CD1
 O
6nr7 1 P12003 86.42 0.0 X-RAY
 2020-01-29 ILE A:155 A:135 18.0 0.103 H -57.6 -40.8 18.0 0.103 0.0 HOH
 5.827
 CG2
 O
1st6 1 P12003 86.42 0.0 X-RAY
 2004-08-03 ILE A:138 A:135 18.0 0.103 H -66.7 -37.3 18.0 0.103 0.0
2gdc 1 P12003 98.12 0.0 X-RAY
 2006-08-08 ILE A:135 A:135 20.0 0.114 H -59.5 -30.7 20.0 0.114 0.0 HOH
 5.260
 CD1
 O
3rf3 1 P18206 100.0 0.0 X-RAY
 2011-04-27 ILE A:135 A:135 17.0 0.097 H -61.3 -37.3 17.0 0.097 0.0 HOH
 2.589
 HD12
 O
ILE B:135 B:135 18.0 0.103 H -61.4 -37.4 NA NA NA
4dj9 1 P18206 100.0 0.0 X-RAY
 2012-02-29 ILE A:135 A:135 19.0 0.109 H -57.4 -39.9 19.0 0.109 0.0 HOH
 3.795
 CG2
 O
2gww 1 P18206 100.0 0.0 X-RAY
 2006-11-14 ILE A:143 A:135 9.0 0.051 H -52.4 -41.7 9.0 0.051 0.0 HOH
 6.158
 O
 O
2hsq 1 P18206 100.0 0.0 X-RAY
 2006-11-21 ILE A:143 A:135 12.0 0.069 H -64.7 -42.9 12.0 0.069 0.0
2ibf 1 P18206 100.0 0.0 X-RAY
 2007-09-18 ILE A:143 A:135 13.0 0.074 H -53.8 -43.3 13.0 0.074 0.0
1rkc 1 P18206 100.0 0.0 X-RAY
 2004-01-13 ILE A:139 A:135 13.0 0.074 H -57.5 -39.4 13.0 0.074 0.0
1rke 1 P18206 100.0 0.0 X-RAY
 2004-01-13 ILE A:139 A:135 17.0 0.097 H -53.3 -39.2 17.0 0.097 0.0 HOH
 5.099
 CG2
 O
1syq 1 P18206 100.0 0.0 X-RAY
 2004-07-20 ILE A:141 A:135 6.0 0.034 H -62.4 -35.8 6.0 0.034 0.0 HOH
 3.673
 CG2
 O
1ydi 1 P18206-2 100.0 0.0 X-RAY
 2005-07-19 ILE A:140 A:135 14.0 0.08 H -58.2 -37.9 14.0 0.08 0.0 HOH
 3.491
 CD1
 O
3tj6 1 P18206 100.0 0.0 X-RAY
 2011-09-07 ILE A:135 A:135 15.0 0.086 H -63.9 -37.5 15.0 0.086 0.0 HOH
 3.681
 CG2
 O
1u6h 1 P12003 98.07 4e-180 X-RAY
 2005-01-18 ILE A:156 A:134 16.0 0.091 H -64.2 -36.9 16.0 0.091 0.0 HOH
 4.482
 CD1
 O
1xwj 1 P12003 98.07 4e-180 X-RAY
 2005-10-11 ILE A:156 A:134 15.0 0.086 H -56.3 -46.0 15.0 0.086 0.0 HOH
 5.248
 CG2
 O
3zdl 1 P12003 98.07 4e-180 X-RAY
 2013-02-13 ILE A:156 A:134 14.0 0.08 H -63.2 -35.7 14.0 0.08 0.0 HOH
 3.851
 CB
 O
6fq4 1 P12003 98.07 4e-180 X-RAY
 2018-05-09 ILE A:156 A:135 9.0 0.051 H -60.9 -39.8 9.0 0.051 0.0
1zvz 1 P12003 98.07 4e-180 X-RAY
 2005-09-20 ILE A:155 A:134 13.0 0.074 H -65.9 -35.9 13.0 0.074 0.0 HOH
 3.841
 CG2
 O
1zw2 1 P12003 98.07 4e-180 X-RAY
 2005-09-20 ILE A:155 A:134 13.0 0.074 H -63.1 -26.5 13.0 0.074 0.0 HOH
 3.594
 CG2
 O
1zw3 1 P12003 98.07 4e-180 X-RAY
 2005-09-20 ILE A:155 A:134 18.0 0.103 H -45.6 -58.2 18.0 0.103 0.0
4e17 1 P12003 98.07 7e-180 X-RAY
 2012-05-16 ILE A:139 A:135 16.0 0.091 H -62.6 -41.7 16.0 0.091 0.0 HOH
 5.722
 O
 O
4e18 1 P12003 98.07 7e-180 X-RAY
 2012-05-16 ILE A:139 A:135 10.0 0.057 H -61.3 -37.3 10.0 0.057 0.0 HOH
 3.776
 CB
 O
3tj5 1 P18206 100.0 9e-180 X-RAY
 2011-09-07 ILE A:135 A:135 14.0 0.08 H -61.2 -36.5 14.0 0.08 0.0 HOH
 3.733
 CG2
 O
3s90 1 P18206 100.0 6e-177 X-RAY
 2011-06-22 ILE A:136 A:135 16.0 0.091 H -60.2 -37.7 16.0 0.091 0.0 HOH
 3.602
 CG2
 O
ILE B:136 B:135 15.0 0.086 H -60.5 -39.2 NA NA NA
4ehp 1 P18206 100.0 6e-177 X-RAY
 2012-04-18 ILE A:136 A:135 11.0 0.063 H -60.4 -37.4 11.0 0.063 0.0 ACT
HOH
 4.962
3.543
 CG2
CG2
 OXT
O
1t01 1 P12003 98.03 3e-176 X-RAY
 2004-08-24 ILE A:136 A:135 12.0 0.069 H -66.4 -32.4 12.0 0.069 0.0 HOH
 4.040
 CB
 O
5y04 1 Q64727 100.0 3e-175 X-RAY
 2018-03-28 ILE A:137 A:135 14.0 0.08 H -59.6 -30.1 14.0 0.08 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p18206-f1 1 P18206 100.0 0.0 ILE A:135 A:135 13.0 0.074 H -59.4 -37.0